Serum levels of irisin, adropin and preptin in obese and athletes

Abstract

The aim of this study is to investigate the endocrine factors thought to play a role in the regulation of energy homeostasis of irisin, adropin and preptin. Our study consists of men between 30-40 years of age including individuals from overweight or obese (n = 25), practicing regular aerobic exercise (n = 25) and sedentary (control, n = 25) groups. Irisin, adropin and preptin levels were studied on blood serum samples prepared using commercially available ELISA kit. The serum irisin level in the obese group was significantly higher than the both exercising and control groups (p <0,05). The serum adropin level in the obese group were significantly lower than control and exercising groups (p <0,05). The serum preptin level in the exercising groups were significantly lower than control (p <0,05). In addition, negative correlation was found between serum adropin and irisin levels (p <0,05). When ROC curves are analyzed, it is seen that high irisin value and low adropin value in obese individuals distinguish obese individuals from other groups with high sensitivity. In this study, serum irisin levels may increase in the obese individuals is due to more muscle activity. In addition, low levels of serum adropin and no change in preptin levels in obese individuals were considered as risk factors in terms of metabolic diseases. As a result, an active lifestyle is suggested to take advantage of the physiological benefits of irisin

Keywords

• irisin
• adropin
• preptin
• exercise
• obesity

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