Bozok Tıp Dergisi 2146-4006 2148-2438 Yozgat Bozok Üniversitesi 10.16919/bozoktip.1133710 Health Care Administration Sağlık Kurumları Yönetimi EFFECT OF VITAMIN D LEVELS ON ASTHMA CONTROL IN ADULTS Astımlı Hastalarda D Vitamini Düzeyinin Astım Kontrolü Üzerine Etkisi Çıftçı Küsbecı Tuba BOZOK ÜNİVERSİTESİ, TIP FAKÜLTESİ, TIP PR. Argun Barış Serap KOCAELİ ÜNİVERSİTESİ, TIP FAKÜLTESİ Yıldız Füsun Krenia University Department of Pulmonology Baştığıt İlknur KOCAELİ ÜNİVERSİTESİ, TIP FAKÜLTESİ, TIP PR. Boyacı Haşim KOCAELİ ÜNİVERSİTESİ, TIP FAKÜLTESİ, TIP PR. Ilgaz Ahmet KOCAELİ ÜNİVERSİTESİ, TIP FAKÜLTESİ, TIP PR. 12 15 2022 12 4 111 119 12 01 2022 Copyright © 2015, Bozok Tıp Dergisi 2015 Bozok Tıp Dergisi

ABSTRACTObjective: The aim of this study is to evaluate the effects of serum vitamin D level and body mass index(BMI) on asthma control and pulmonary functions in asthmatic patients.Material and Methods: Thirty-five healthy normal controls and 60 patients with asthma were included inthe study between December 2016 and February 2017. At initial admission, demographic characteristicsand pulmonary function tests (PFT) were recorded and laboratory tests including serum vitamin D, calcium,phosphorus, parathormone and alkaline phosphatase levels were measured. Asthma control test (ACT) wasperformed to asthmatic patients. Fifty-three patients with asthma and 32 healthy controls with decreasedvitamin D level were consulted with Endocrinology Department for vitamin D replacement therapy. ACT andPFT were repeated after therapy at third month in asthmatic patients.Results: There were totally 95 individuals; 76 females (80%) and 19 males (20%), There were no significantdifference between age, gender and demographic characteristics between asthmatics and controlgroup. Smoking status and passive smoking rates were similar. There was no significant difference betweendaily sun exposure, calcium containing diet and menopausal status. Serum phosphorus, calcium, alkalinephosphatase, parathormone and 25-hydroxyvitamin D levels were similar in both groups. Vitamin levelswere low in about 90% of both groups. On the first admission, 71.7% of asthmatic patients were uncontrolled,while the rate of uncontrolled patients decreased to 13.2% after the post-replacement evaluation.There was a significant increase of ACT with respect to vitamin D replacement therapy (22.4 ± 2.7 vs 16 ±5.4, p=0.001). The mean BMI were high in both groups (≥30 kg/m²). The mean ACT score was lower in obeseasthmatics than in non-obese patients, but the difference was not significant (15.3 ± 5.4 vs. 17.5 ± 4.8, p=0.1). Presence of controlled or uncontrolled disease was similar between the obese and non-obese groups(p = 0.744).Conclusion: It is suggested that vitamin D replacement therapy had positive effects on asthma control andpulmonary functions but further multicenter, prospective studies with large number of cases are needed toevaluate the effect of vitamin D replacement therapy on these parameters.Keywords: Asthma; Vitamin D; Asthma Control Test (ACT); Pulmonary Function Test (PFT)

 EFFECT OF VITAMIN D LEVELS ON ASTHMA CONTROL IN ADULTS Astımlı Astımlı Hastalarda D Vitamini Düzeyinin Astım Kontrolü Üzerine Etkisi EFFECT OF VITAMIN D LEVELS ON ASTHMA CONTROL IN ADULTS Astımlı Astımlı Hastalarda D Vitamini Düzeyinin Astım Kontrolü Üzerine Etkisi 1. Elisabeth H. Bel. Clinical phenotypes of asthma in Korea. Curr Opin Pulm Med. 2016;10(1):44–50. 2. Moore WC, Meyers DA, Wenzel SE, Teague WG, Li H, Li X, et al. Identification of asthma phenotypes using cluster analysis in the severe asthma research program. Am J Respir Crit Care Med. 2010;181(4):315–23. 3. Wenzel SE. Asthma phenotypes: The evolution from clinical to molecular approaches. Nat Med. 2012;18(5):716–25. 4. Global initiative for asthma: Asthma management and prevention, 2015. 2015. 5. Global initiative for asthma: Asthma management and prevention, 2019. Vol. 49, Practice Nurse. 2019. 200 p. 6. Masoli M, Fabian D, Holt S, Beasley R. The global burden of asthma: Executive summary of the GINA Dissemination Committee Report. Allergy Eur J Allergy Clin Immunol. 2004;59(5):469–78. 7. Luong KVQ, Hoàng Nguyễn LT. The role of vitamin D in asthma. Pulm Pharmacol Ther. 2012;25(2):137–43. 8. Iqbal SF, Freishtat RJ. Mechanism of action of vitamin D in the asthmatic lung. J Investig Med. 2011;59(8):1200–2. 9. Hughes DA, Norton R. Vitamin D and respiratory health. Clin Exp Immunol. 2009;158(1):20–5. 10. Özkan B. Nutritional Rickets-Review. J Clin Res Pediatr Endocrinol. 2010 8;2(4):137–43