ÇOCUKLARDA ALKOLİK OLMAYAN YAĞLI KARACİĞER HASTALIĞI

Yıl 2014, Cilt: 4 Sayı: 1, 55 - 61, 06.08.2014

Meltem Uğraş Öznur Küçük , Suat Biçer Ayça Vitrinel

https://doi.org/10.16919/btd.90084

Cited By: 1

Öz

Gelişen yaşam koşulları ile obezite ve komplikasyonları da artmaktadır. Alkolik Olmayan Yağlı Kara- ciğer Hastalığı (AOYKH)/ Alkolik Olmayan Steatohepatit (AOSH) gerçek prevalansı tahmin edilenin daha üzerindedir. Tanının tesadüfen konulduğu ancak çocukluk çağında nadiren de siroza neden olan bu hastalık, rutin muayene sırasında artmış ALT/AST oranı, ultrason (USG) de belirgin karaci- ğer ile tanınabilir. Karaciğer biyopsisi özellikli hastalarda tanı koymada altın standarttır. Klinik gidiş hakkında net veriler yoktur. Obezite, insülin direnci ve dislipidemi durumlarında histolojik bulgular daha ilerlemiştir ve prognoz daha kötü olabilir. İzole yağlanma en iyi prognoza sahip iken, fibrozisin eşlik ettiği hepatosit hasarı varlığında prognoz daha kötüleşmektedir. Karaciğer biyopsisi sırasında hastaların %7-16’sında siroz gelişmiştir. Tedavide kilo verme ve egzersiz en önemli rolü oynamakta- dır. İlaçlar konusunda çocuklarda kesinleşmiş veriler yoktur.

Anahtar Kelimeler

Çocuk, Non-alkolik yağlı karaciğer hastalığı, Siroz

Kaynakça

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