Association Between Obesity, C-Reactive Protein and Serum Total IgE with Skin Prick Test Results in Patients with Allergic DiseasesEconomic Situation

Yıl 2019, Cilt: 9 Sayı: 4, 109 - 116, 27.12.2019

Yavuz Selim İntepe , Eylem Yıldırım Emine Çölgeçen Zeliha Kapusuz Gencer Bülent Çiftçi

Öz

Aim: To evaluate relationship between skin prick test results and serum total IgE,
C-reactive protein, body mass index in patients with allergic diseases.
Material and methods: This study was conducted in university hospital between October 2011 and
September 2018. Skin Prick test (SPT) was applied to 433 patients in chest diseases clinic who were referred
with diagnosis of asthma, allergic rhinitis, chronic urticaria and atopic dermatitis. Also patients’ serum total
IgE, C-reactive protein (CRP) levels and body mass index (BMI) measurements were evaluated.
Results: The study group were consisted of 433 patients, 189 (43.6%) male, and 244 (56.4%) female.
According to the diagnosis, 177 (40.9%) patients had asthma, 108 (24.9%) had allergic rhinitis, 82(18.9%)
had atopic dermatitis and 66 (15.2%) had chronic urticaria. SPT was positive in 285 (65.8%) patients while
negative in 148(34.2%). Most frequently seen allergens were the mixture of trees 23.2%, home dust 19.2%,
savage grass 14.8%. Total IgE, CRP, and BMI values were statistically higher in SPT positive group (p=0.001).
Obese patients had statistically significant positive skin prick results (p=0.036). Also, positive total IgE and
CRP groups were significantly higher in positive SPT group (p =0.001 and p=0.008). There was a moderate
level and significant positive correlation between total IgE levels and SPT (r=0.463, p=0.001). Also CRP levels
(r= 0.128, p=0.008) and obesity (r=0.101, p=0.036) had a low level and significant positive correlation with
SPT. Only total IgE was the statistically significant risk factor for the SPT. Positive total IgE level increases the
probability of positive SPT by 8.11 times.
Conclusion: This study suggests that elevated levels of total IgE, CRP and obesity may have relationship with
atopy by increased likelihood of positive skin prick test. Positive Total IgE level can be a strong predictor for
skin prick test positivity

Anahtar Kelimeler

Atopy, C-Reactive Protein, Obesity, Skin prick Test, Total IgE

ALLERJİK HASTALIKLARI OLAN HASTALARDA OBEZİTE, C-REAKTİF PROTEİN (CRP) VE SERUM TOTAL IGE ARASINDAKİ İLİŞKİNİN DERİ PRİCK TESTİ SONUÇLARI İLE İLİŞKİSİ

Öz

Amaç: Alerjik hastalığı olan hastalarda cilt prick test sonuçları ile serum total IgE, C-reaktif protein, vücut
kitle indeksi arasındaki ilişkiyi değerlendirmek.
Metod: Bu çalışma Ekim 2011 ile Eylül 2018 tarihleri arasında üniversite hastanesinde yapıldı. Astım, alerjik
rinit, kronik ürtiker ve atopik dermatit tanısı ile başvuran göğüs hastalıkları kliniğindeki 433 hastaya deri
prik testi (DPT) uygulandı. Ayrıca hastaların serum total IgE, C-reaktif protein (CRP) düzeyleri ve vücut kitle
indeksi ölçümleri (BMI) değerlendirildi.
Bulgular: Çalışma grubu 433 hastadan oluşmaktadır, 189'u (% 43,6) erkek, 244'ü (% 56,4) kadındı. Tanıya
göre 177 (% 40,9) hastada astım, 108 (% 24,9) hastada alerjik rinit, 82 (% 18,9) hastada atopik dermatit
ve 66'sında (% 15,2) kronik ürtiker vardı. SPT 285 (% 65,8) hastada pozitif, 148 (% 34,2) hastada negatif
bulundu. En sık görülen alerjenler % 23.2, ev tozu % 19.2, vahşi çimenlerde % 14.8 ağaç karışımıydı. DPT
pozitif grupta total IgE, CRP ve BMI değerleri istatistiksel olarak daha yüksekti (p=0.001). Obez hastalarda
istatistiksel olarak anlamlı pozitif deri prik sonuçları vardı (p = 0.036). Ayrıca pozitif total IgE ve CRP grupları
pozitif DPT grubunda anlamlı olarak daha yüksekti (p =0.001 ve p = 0.008). Total IgE düzeyleri ile DPT arasında orta düzeyde ve anlamlı pozitif korelasyon vardı (r = 0.463, p=0.001). Ayrıca CRP seviyeleri (r = 0.128, p
= 0.008) ve obezite (r = 0.101, p = 0.036) düşük seviyede ve DPT ile anlamlı pozitif korelasyon gösterdi. DPT
için sadece total IgE istatistiksel olarak anlamlı risk faktörü idi. Pozitif total IgE düzeyi, pozitif SPT olasılığını
8.11 kat arttırır.
Sonuç: Bu çalışma, yüksek total IgE, CRP ve obezite düzeylerinin, pozitif deri prik testi olasılığının artmasıyla
atopi ile ilişkiye sahip olabileceğini göstermektedir. Pozitif total IgE düzeyi, deri prik test pozitifliği için güçlü
bir prediktör olabilir.

Anahtar Kelimeler

ALLERJİK HASTALIKLARI OLAN HASTALARDA OBEZİTE, C-REAKTİF PROTEİN (CRP) VE SERUM TOTAL IGE ARASINDAKİ İLİŞKİNİN DERİ PRİCK TESTİ SONUÇLARI İLE İLİŞKİSİ Association Between Obesity

Kaynakça

• 1. Fischer-Posovszky P, Wabitsch M, Hochberg Z. Endocrinology of adipose tissue - an update. Horm Metab Res. 2007 May;39(5):314-21. 2. Gorgievska-Sukarovska B, Lipozencić J, Susac A. Obesity and allergic diseases. Acta Dermatovenerol Croat. 2008; 16:231-5. 3. Halvani A, Tahghighi F, Nadooshan HH. Evaluation of correlation between airway and serum inflammatory markers in asthmatic patients. Lung India. 2012 Apr;29(2):143-6 4. Butland BK, Strachan DP, Rudnicka AR. C-reactive protein, obesity, atopy and asthma symptoms in middle-aged adults. Eur Respir. 2008 Jul;32(1):77-84. 5. Olafsdottir IS, Gislason T, Thjodleifsson B, Olafsson I, Gislason D, Jögi R, et al. C reactive protein levels are increased in non-allergic but not allergic asthma: a multicentre epidemiological study. Thorax. 2005 Jun;60(6):451-4. 6. Panaszek B, Liebhart E, Liebhart J, Pawłowicz R, Fal AM. Serum concentration of C-reactive protein is not a good marker of bronchial hyperresponsiveness. Arch Immunol Ther Exp (Warsz). 2007 Sep-Oct;55(5):341-5. 7. Kony S, Zureik M, Driss F, Neukirch C, Leynaert B, Neukirch F. Association of bronchial hyperresponsiveness and lung function with C-reactive protein (CRP): a population based study. Thorax. 2004 Oct;59(10):892-6. 8. Johansson SG, Bieber T, Dahl R, Friedmann PS, Lanier BQ, Lockey RF, et al. Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003. J Allergy Clin Immunol. 2004 May;113(5):832-6. 9. Chang ML, Cui C, Liu YH, et al. Analysis of total immunoglobulin E and specific immunoglobulin E of 3,721 patients with allergic disease. Biomed Rep. 2015 Jul;3(4):573-577. 10. Lokaj-Berisha V, Gacaferri-Lumezi B, Minci-Bejtullahu G, et al. Gender Associated High Body Mass Index in Allergic Diseases. Open Access Maced J Med Sci. 2015 Mar 15;3(1):69-74.