ST-YÜKSELMELİ MİYOKARD ENFARKTÜSÜ (STYME) HASTALARINDA HASTANE İÇİ MAJÖR KARDİYAK OLAYLARIN ÖNGÖRDÜRÜCÜSÜ: SERUM POTASYUM DÜZEYLERİNDEKİ DEĞİŞKENLİK ORANI Variability Rate of Serum Potassium Levels Predicts Inhospital Major Adverse Cardiac Events in Patients with STElevation Myocardial Infarction (STEMI)

Yıl 2019, Cilt: 9 Sayı: 4, 124 - 130, 27.12.2019

Ali Nazmi Çalık Tufan Çınar Mehmet Baran Karataş Kazım Serhan Özcan Yiğit Çanga Ahmet Öz Osman Bolca Ömer Kozan

Öz

ÖZET
Amaç: Potasyumun (K+) kardiyovasküler hastalıklardaki kritik rolü ve olumsuz kardiyak olayları önlemede
normokalemik durumu devam ettirmenin önemi her geçen gün daha iyi anlaşılmaktadır. Çalışmamızda, normal
sınırlar içerisinde olmasına rağmen, serum potasyum düzeylerindeki değişkenlik oranı ile ST-yükselmeli
miyokard enfarktüsü (STyME) hastalarında izlenen hastane içi majör kardiyak olaylar (MACE) arasındaki ilişkiyi
araştırmayı amaçladık.
Gereç ve Yöntemler: 2013 – 2015 yılları arasında tersiyer merkezimize STyME tanısı ile başvuran toplam 419
hasta retrospektif olarak dizayn edilen çalışmamıza dahil edildi. Hastaneye başvuru anında veya hastane içi
takipleri sırasında normal değerlerin dışında K+ düzeyi saptanan hastalar çalışmaya alınmaz iken, hastane
yatışı boyunca en az 5 (beş) ardışık K+ değeri mevcut olan hastalar çalışmaya dahil edildi.
Bulgular: Çok değişkenli regresyon analizinde, çalışma populasyonundaki serum K+ düzeylerinin değişkenlik
oranı (OR: 7.84, 95%CI: 1.18-51.81, p=0.03) hastane içi olumsuz kardiyak olayların (MACE) bağımsız öngördürücüsü
olarak saptandı. Serum K+ düzeylerinin değişkenlik oranı ? 0.57 (optimal kestirim değeri) olması
halinde, hastane içi olumsuz olayları % 46.2 duyarlılık ve % 84.9 özgüllükle öngörmekteydi. [area under
curve (AUC) 0.66, p=0.001].
Sonuç: Çalışmamızın sonuçları, normal sınırlar içinde olsa dahi değişkenlik gösteren K+ düzeylerinin STyME
hastalarında hastane içi olumsuz olayların bağımsız bir öngördürücüsü olabileceğini göstermiştir. Bu nedenle,
artmış oranda K+ düzeyi değişkenliği gösteren hastaların daha yakından takibi olumsuz kardiyak olayları
en aza indirmek açısından büyük önem arz etmektedir.
Anahtar kelimeler: Potasyum; ST-yükselmeli miyokard enfarktüsü; Majör olumsuz kardiyak olaylar
ABSTRACT
Objective: The critical role of potassium (K+) in cardiovascular disease and, maintaining a normokalemic
state are increasingly being recognized to preclude adverse cardiac events. The main objective of our study
was to evaluate whether there is an association between the variability of serum potassium levels, even
within the normal range, and in-hospital major adverse cardiovascular events (MACE) in patients with STelevation
myocardial infarction (STEMI).
Materials and Method: A total of 419 patients who were admitted to our tertiary heart center with a diagnosis
of STEMI from May 2013 to May 2015 were included in this retrospective study. The patients who
have any serum K+ levels beyond the normal range on admission and during the in-hospital follow-up interval
were excluded. The patients who had at least five consecutive serum K+ measurements during the
in-hospital stay were included in the study.
Results: In multivariable logistic regression analysis, the variability of serum K+ levels (OR: 7.84, 95%CI: 1.18-
51.81, p=0.03) was found to be independently associated with MACE in the study population. The optimal
cut-off value of the variability of serum K+ levels was ? 0.57 with a sensitivity of 46.2% and a specificity of
84.9% [area under curve (AUC) 0.66, p=0.001].
Conclusion: Our findings provide evidence that variability of serum K+ levels even within the normal range
may be an independent predictor of MACE in STEMI patients. Therefore, close follow up of the patients with
a high variability of serum K+ levels has utmost importance in order to minimize the risk of MACE.
Keywords: Potassium; ST-elevation myocardial infarction; Major adverse cardiovascular events

Anahtar Kelimeler

ST-YÜKSELMELİ MİYOKARD ENFARKTÜSÜ (STYME) HASTALARINDA HASTANE İÇİ MAJÖR KARDİYAK OLAYLARIN ÖNGÖRDÜRÜCÜSÜ: SERUM POTASYUM DÜZEYLERİNDEKİ DEĞİŞKENLİK ORANI Variability Rate of Serum Potassium Levels Predicts Inhospital Major Adverse Cardiac Events in Patients with STElevation Myocardial Infarction (STEMI)

Kaynakça

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