PREEKLAMPSİDE SİSTEMİK ENFLAMATUAR CEVAP BELİRTEÇLERİ Systemic Inflammation Response Markers in Preeclampsia

Yıl 2020, Cilt: 10 Sayı: 2, 159 - 163, 08.06.2020

Taylan Onat Demet Aydoğan Kırmızı Melike Demir Çaltekin Emre Başer Ethem Serdar Yalvaç

Öz

ÖZET
Amaç: Preeklamptik ve sağlıklı gebelerde; sistemik enflamatuar cevap belirteçlerinin değerlendirilmesi ve
hastalığı predikte etmedeki etkisinin belirlenmesidir.
Gereç ve Yöntem: Çalışmamız Mart 2017/Mayıs 2019 tarihleri arasında yapılmış, retrospektif bir çalışmadır.
Preeklamptik hastalar ile sağlıklı gebelerin verileri hasta dosyalarından ve hastane bilgi yönetim sistemi
taranarak elde edildi. Kontrol grubu oluşturulurken PE grubu ile yaş ve VKİ parametrelerinde istatiksel anlamlı
farklılık olmamasına dikkat edildi. Gestasyonel diyabetes mellitus, tip I-II diyabetes mellitus, çoğul
gebelikler, böbrek hastalıkları, karaciğer hastalıkları, tiroid hastalıkları, kronik enflamatuvar hastalıklar, akut
enfeksiyonlar ve kortikosteroid kullanan gebeler çalışma dışı bırakıldı.
Bulgular: Çalışmaya 39 preeklamptik gebe ve 91 sağlıklı gebe dahil edildi. Çalışmaya dahil edilen kadınların
yaş ortalaması 30.5±5.26; vücut kitle indeksi ortalaması 27.9±4.28 idi. Gruplar arasında yaş ve vücut kitle
indeksi değerleri anlamlı değildi. Parite, sistolik ve diastolik kan basınçları gruplar arasında anlamlı olarak
farklıydı. Fakat nötrofil/lökosit oranı (NLR), platelet/lenfosit oranı (PLR) ve lenfosit/monosit oranı (LMR)
değerlendirildiğinde gruplar arasında anlamlı bir farklılık saptanmadı.
Sonuç: Çalışmamızda preeklamptik ve sağlıklı grupta sistemik enflamatuar cevap belirteçleri açısından farklılık
saptanmamıştır.
Anahtar kelimeler: Gebelik; hipertansiyon; preeklampsi; enflamasyon
ABSTRACT
Aim: In preeclamptic and healthy pregnant women; the evaluation of systemic inflammatory response
markers and determining the effect in predicting the disease.
Material and Methods: Our study is a retrospective study conducted between March 2017 / May 2019. The
data of preeclamptic patients and healthy pregnant women were obtained by scanning patient files and
hospital information management system. While forming the control group, it was paid attention that there
was no statistically significant difference for age and BMI parameters between groups. Pregnant women
with gestational diabetes mellitus, type I-II diabetes mellitus, multiple pregnancies, kidney diseases, liver
diseases, thyroid diseases, chronic inflammatory diseases, acute infections and using corticosteroids were
excluded.
Results: Thirty nine preeclamptic pregnant women and 91 healthy pregnant women were included in the
study. The average age included women in the study was 30.5 ± 5.26; mean body mass index was 27.9 ±
4.28. Age and body mass index values were not significant between the groups. Parity, systolic and diastolic
blood pressures were significantly different between the groups. However, when neutrophil / leukocyte
ratio (NLR), platelet / lymphocyte ratio (PLR) and lymphocyte / monocyte (LMR) ratio were evaluated, no
significant difference was found between the groups.
Conclusion: In our study, no difference was found in terms of systemic inflammatory response markers in
preeclamptic and healthy groups.
Keywords: Pregnancy; hypertension; preeclampsia; inflammation

Anahtar Kelimeler

PREEKLAMPSİDE SİSTEMİK ENFLAMATUAR CEVAP BELİRTEÇLERİ Systemic Inflammation Response Markers in Preeclampsia

Kaynakça

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