EFFECT OF VITAMIN D LEVELS ON ASTHMA CONTROL IN ADULTS Astımlı Hastalarda D Vitamini Düzeyinin Astım Kontrolü Üzerine Etkisi

Yıl 2022, Cilt: 12 Sayı: 4, 111 - 119, 15.12.2022

Tuba Çıftçı Küsbecı Serap Argun Barış Füsun Yıldız İlknur Baştığıt Haşim Boyacı Ahmet Ilgaz

Öz

ABSTRACT
Objective: The aim of this study is to evaluate the effects of serum vitamin D level and body mass index
(BMI) on asthma control and pulmonary functions in asthmatic patients.
Material and Methods: Thirty-five healthy normal controls and 60 patients with asthma were included in
the study between December 2016 and February 2017. At initial admission, demographic characteristics
and pulmonary function tests (PFT) were recorded and laboratory tests including serum vitamin D, calcium,
phosphorus, parathormone and alkaline phosphatase levels were measured. Asthma control test (ACT) was
performed to asthmatic patients. Fifty-three patients with asthma and 32 healthy controls with decreased
vitamin D level were consulted with Endocrinology Department for vitamin D replacement therapy. ACT and
PFT were repeated after therapy at third month in asthmatic patients.
Results: There were totally 95 individuals; 76 females (80%) and 19 males (20%), There were no significant
difference between age, gender and demographic characteristics between asthmatics and control
group. Smoking status and passive smoking rates were similar. There was no significant difference between
daily sun exposure, calcium containing diet and menopausal status. Serum phosphorus, calcium, alkaline
phosphatase, parathormone and 25-hydroxyvitamin D levels were similar in both groups. Vitamin levels
were low in about 90% of both groups. On the first admission, 71.7% of asthmatic patients were uncontrolled,
while the rate of uncontrolled patients decreased to 13.2% after the post-replacement evaluation.
There was a significant increase of ACT with respect to vitamin D replacement therapy (22.4 ± 2.7 vs 16 ±
5.4, p=0.001). The mean BMI were high in both groups (≥30 kg/m²). The mean ACT score was lower in obese
asthmatics than in non-obese patients, but the difference was not significant (15.3 ± 5.4 vs. 17.5 ± 4.8, p=
0.1). Presence of controlled or uncontrolled disease was similar between the obese and non-obese groups
(p = 0.744).
Conclusion: It is suggested that vitamin D replacement therapy had positive effects on asthma control and
pulmonary functions but further multicenter, prospective studies with large number of cases are needed to
evaluate the effect of vitamin D replacement therapy on these parameters.
Keywords: Asthma; Vitamin D; Asthma Control Test (ACT); Pulmonary Function Test (PFT)

Anahtar Kelimeler

EFFECT OF VITAMIN D LEVELS ON ASTHMA CONTROL IN ADULTS, Astımlı, Astımlı Hastalarda D Vitamini Düzeyinin Astım Kontrolü Üzerine Etkisi

Kaynakça

• 1. Elisabeth H. Bel. Clinical phenotypes of asthma in Korea. Curr Opin Pulm Med. 2016;10(1):44–50.
• 2. Moore WC, Meyers DA, Wenzel SE, Teague WG, Li H, Li X, et al. Identification of asthma phenotypes using cluster analysis in the severe asthma research program. Am J Respir Crit Care Med. 2010;181(4):315–23.
• 3. Wenzel SE. Asthma phenotypes: The evolution from clinical to molecular approaches. Nat Med. 2012;18(5):716–25.
• 4. Global initiative for asthma: Asthma management and prevention, 2015. 2015.
• 5. Global initiative for asthma: Asthma management and prevention, 2019. Vol. 49, Practice Nurse. 2019. 200 p.
• 6. Masoli M, Fabian D, Holt S, Beasley R. The global burden of asthma: Executive summary of the GINA Dissemination Committee Report. Allergy Eur J Allergy Clin Immunol. 2004;59(5):469–78.
• 7. Luong KVQ, Hoàng Nguyễn LT. The role of vitamin D in asthma. Pulm Pharmacol Ther. 2012;25(2):137–43.
• 8. Iqbal SF, Freishtat RJ. Mechanism of action of vitamin D in the asthmatic lung. J Investig Med. 2011;59(8):1200–2.
• 9. Hughes DA, Norton R. Vitamin D and respiratory health. Clin Exp Immunol. 2009;158(1):20–5.
• 10. Özkan B. Nutritional Rickets-Review. J Clin Res Pediatr Endocrinol. 2010 8;2(4):137–43