Alkole Bağlı Olmayan Yağlı Karaciğer Hastalığı Patogenezinde Mikrobiyotanın ve Risk Faktörlerinin Rolü: Güncel Bulgular ve Tedavi Stratejileri

Abstract

Alkole bağlı olmayan yağlı karaciğer hastalığı (NAYKH)’nın dünya çapında tahmini yaygınlığı %25’tir. Makalede NAYKH’nın, bağırsak mikrobiyotası ve diğer risk faktörleri ile ilişkisi ve bu faktörlerin NAYKH patogenezinde oynadığı role ilişkin bilgiler araştırılmış ve değerlendirilmiştir. NAYKH, anormal derecede artan yağ sentezi ve bunu takip eden hepatositlerde yağ birikimi ile karakterize bir hastalıktır. Bağırsak mikrobiyotasındaki disbiyoz, bağırsak florasının bozulması, bağırsakta bakterilerin aşırı çoğalması, bağırsak bariyerinin bozulması, bakteriyel endotoksinlerinin karaciğere portal yollar taşınması, safra asidi profillerinin değişmesi ve kısa zincirli yağ asidlerinin azalması, NAYKH gelişmesinde rol oynayan diğer faktörlerdir. NAYKH’nin önlenmesinde, bağırsak mikrobiyotasını hedef alan uygulamalar ve tedavi edici stratejiler önemli katkılar sağlayabilir.

Keywords

• Metabolik Karaciğer Hastalığı
• Mikrobiyota
• Alkole Bağlı Olmayan Yağlı Karaciğer Hastalığı

The Role of Microbiota and Risk Factors in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: Current Findings and Therapeutic Strategies

Abstract

The estimated prevalence of non-alcoholic fatty liver disease (DD) worldwide is 25%. The article investigates and evaluates the relationship between NAFLD and gut microbiota and other risk factors, and the role of these factors in the pathogenesis of NAFLD. NAFLD is characterized by abnormally increased fat synthesis and subsequent hepatocyte fat accumulation. Dysbiosis in gut microbiota, disruption of gut flora, overgrowth of bacteria in the gut, disruption of the intestinal barrier, portal transport of bacterial endotoxins to the liver, alteration of bile acid profiles, and reduction of short-chain fatty acids are other factors that play a role in the development of NAFLD. Applications and therapeutic strategies targeting gut microbiota may significantly contribute to preventing NAFLD.

Keywords

• Metabolic Liver Disease
• Microbiota
• Non-Alcoholic Fatty Liver Disease

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