Yıl 2021,
, 168 - 174, 01.05.2021
Gökçe Özdemir
,
Elmas Ersöz
,
Nazik Dilek
Öz
Apiterapi, Latince arı anlamına gelen apis kelimesinden türetilmiş bir kelimedir. Apiterapi uygulaması yüzlerce yıl önceye dayanmaktadır. Antik Mısır ve Çin’de hekimlerin günümüzden 4 bin yıl önce bazı arı ürünlerini kullandıklarını gösteren belgeler bulunmaktadır. Apiterapi, sağlığın korunması ve hastalıkların tedavisinde etkili bir yöntem olarak kullanılmaktadır. Bu yöntemde
kullanılan başlıca ürünler, bal, apilarnil, propolis, arı sütü ve pergadır. Apiterapide kullanılan bu ürünlerin genellikle antibakteriyel, antioksidan, antiinflamatuar, vazodilatif ve antitümör etki gibi çok önemli etkilere sahip olduğu bilinmektedir. Olumlu etkilerinin yanı sıra apiterapi ürünlerinin bazılarının kullanımının allerjik reaksiyona sebep olabileceği de çalışmalarda gösterilmiştir. Sonuç olarak güvenilir kaynaklardan elde edilen bu besin maddelerinin kullanımının sağlık üzerine yararlı etkileri bulunmaktadır.
Kaynakça
- Abd-El Aal AM, El-Hadidy MR, El-Mashad NB, El-Sebaie AH. 2007. Antimicrobial effect of bee honey in comparison to antibiotics on organisms isolated from infected burns. Ann Burns Fire Disasters, 20(2): 83-88.
- Abel SDA, Baird SK. 2018. Honey is cytotoxic towards prostate cancer cells but interacts with the MTT reagent: Considerations for the choice of cell viability assay. Food Chem, 241: 70-78.
- Abouda Z, Zerdani I, Kalalou I, Faid M, Ahami MJRJoM2011 The antibacterial activity of Moroccan bee bread and bee-pollen (fresh and dried) against pathogenic bacteria. Res J Microbiol, 6(4): 376-384.
- Afroz R, Tanvir E, Little PJC. 2016. Honey-derived flavonoids: natural products for the prevention of atherosclerosis and cardiovascular diseases. Clin Exper Pharmacol, 6(3): 1-4.
- Ajibola A, Chamunorwa JP, Erlwanger KH. 2012. Nutraceutical values of natural honey and its contribution to human health and wealth. Nutri Metabol, 9(1): 61.
- Ajibola A. 2015. Novel insights into the health importance of natural honey. The Malaysian J Med Sci, 22(5): 7-22.
- Akyol E. 2015. Structure of royal jelly, importance for humans and bees. Uludağ Arıcılık Derg, 15(1): 16-21.
- Altıntaş L, Bektaş N. 2019. Apiterapi: 1. Ari zehri. Uludag Bee J, 19(1): 82-95.
- Annav T, Mari J, Ioanna C, Konstadia G, Tiina T, Vesa V, Paraskevi M. 2009. Bioactivity of Greek honey extracts on breast cancer (MCF-7), prostate cancer (PC-3) and endometrial cancer (Ishikawa) cells: Profile analysis of extracts. Food Chem, 116(3):702-708.
- Annila IJC, Allergy E. 2000. Bee venom allergy. J British Soc Allergy Clin Immun, 30(12): 1682-1687.
- Attia WY, Gabry MS, El-Shaikh KA, Othman GA. 2008. The anti-tumor effect of bee honey in Ehrlich ascite tumor model of mice is coincided with stimulation of the immune cells. The Egyptian J Immunol, 15(2): 169-183.
- Aydın, Y, Tekeog lu. 201 . Tamamlayıcı tıp ve gu ncel apiterapı uygulamaları. J Biotechnol Strat Health Res, 2(2): 64-73.
- Bakour M, Fernandes Â, Barros L, Sokovic M, Ferreira ICFR, Badiaa l. 2019. Bee bread as a functional product: Chemical composition and bioactive properties. Food Sci Technol, 109: 276-282.
- Bangroo AK, Khatri R, Chauhan, S. 2005. Honey dressing in pediatric burns. J Indian Assoc Pediatric Surgeons, 10(3): 172-175.
- Bilsel Y, Bugra D, Yamaner S, Bulut T, Cevikbas U, Turkoglu U. 2002. Could honey have a place in colitis therapy? Effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation. Digestive Surgery, 19(4): 306-312.
- Bincoletto C, Eberlin S, Figueiredo CA, Luengo MB, Queiroz ML. 2005. Effects produced by Royal Jelly on haematopoiesis: relation with host resistance against Ehrlich ascites tumour challenge. Inter Immunopharmacol, 5(4): 679-88.
- Bogdanov S, Jurendic T, Sieber R, Gallmann P. 2008. Honey for nutrition and health: A review. J American College Nutri, 27(6): 677-689.
- Celimli N. 2004. Veteriner hekimlikte yara sağaltiminda bal kullanimi. Veteriner Cerrahi Derg, 10(3-4), 73-77.
- Choi CS, Park JK, An CG, Lee EH, Ahn KJ. 2015. Multiple benefits of bee venom in aged skin manifestations. Asian J Beauty Cosmetol, 13(5): 679-688.
- Çelik K, Aşgun HF. 2020. Arilarla gelen sağlık “apiterapi”. Tudás Alapítvány, İstanbul, Türkiye, pp. 104.
- Delavarian Z, Paakfetrat A, Nazari F, Tonekaboni A, Shakeri MT. 2015. An investigation of the effects propolis on the recurrent oral aphthous ulcers. Avicenna J Phytomed, 5(1): p113.
- Devagondanahalli HM, Suan CL. 2014. The anti-inflammatory and wound healing properties of honey. European Food Res Technol, 239(6), 1003-1014.
- Doğanyiğit Z, Okan A, Kaymak E, Pandır D, Silici S. 2020. Investigation of protective effects of apilarnil against lipopolysaccharide induced liver injury in rats via TLR 4/ HMGB-1/ NF-κB pathway. Biomed Pharmacotherapy, 125: 109967.
- Erdem B, Özkök A. 201 . Can Food Supplement Produced from Apilarnil be an Alternative to Testosterone Replacement Therapy? Hacettepe J Biology Chem, 45(4): 635-638.
- Gekker G, Hu S, Spivak M, Lokensgard JR, Peterson PK. 2005. Anti-HIV-1 activity of propolis in CD4+ lymphocyte and microglial cell cultures. J Ethnopharmacology, 102(2): 158-163.
- Hamamcı M, Doganyigit Z, Silici S, Okan A, Kaymak E, Yilmaz S, Tokpinar A, Inan LE. 2020. Apilarnil: A Novel Neuroprotective Candidate. Acta Neurologica Taiwanica, 29(2): 33-45.
- Han X, Shen T, Lou H. 2007. Dietary polyphenols and their biological significance. Inter J Molec Sci, 8(9): 950-988.
- Harish Z, Rubinstein A, Golodner M, Elmaliah M, Mizrachi Y. 1997. Suppression of HIV-1 replication by propolis and its immunoregulatory effect. Drugs Under Experiment Clinical Res, 23(2), 89-96.
- Hassan MI, Mabrouk GM, Shehata HH, Aboelhussein MM. 2012. Antineoplastic effects of bee honey and Nigella sativa on hepatocellular carcinoma cells. Integrative Cancer Therapies, 11(4), 354-363.
- Hidaka S, Okamoto Y, Uchiyama S, Nakatsuma A, Hashimoto K, Ohnishi ST, Yamaguchi M. 2006. Royal jelly prevents osteoporosis in rats: beneficial effects in ovariectomy model and in bone tissue culture model. Evidence-based Complement Alternat Med, 3(3): 339-348.
- Israili ZH. 2014. Antimicrobial properties of honey. American J Therapeutics, 21(4): 304-323.
- Ito J, Chang FR, Wang HK, Park YK, Ikegaki M, Kilgore N, Lee KH. 2001. Anti-AIDS agents48Anti-HIV activity of moronic acid derivatives and the new melliferone-related triterpenoid isolated from Brazilian propolis. J Natural Products, 64(10): 1278-1281.
- Jo M, Park MH, Kollipara PS, An BJ, Song HS, Han SB, Kim JH, Song MJ, Hong JT. 2012. Anti-cancer effect of bee venom toxin and melittin in ovarian cancer cells through induction of death receptors and inhibition of JAK2/STAT3 pathway. Toxicology Applied Pharmacolog, 258(1): 72-81.
- Karaman M, Artık N, Küçükersan K, Halıcı Z, Çelik M. 2016. Perga (Bee Bread) composition and health benefit. In: Proceedings of 2nd Inter Turkic World Conference on Chemical Sci Technologies, April 01-30,Turkey.
- Khalifa SAM, Elashal M, Kieliszek M, Ghazala NE, Farag MA, Saeed A, Xiao J, boZou Z, Khatib A, Göransson U, El-Seedi HR. 2020. Recent insights into chemical and pharmacological studies of bee bread. Trends Food Sci Technol, 97: 300-316.
- Kim S, Hong I, Woo S, Jang H, Pak S, Han S. 2017. Isolation of Abscisic Acid from Korean Acacia Honey with Anti-Helicobacter pylori Activity. Pharmacognosy Magazine, 13(2): 170-173.
- Kogalniceanu S, Lancrajan I, Ardelean G. 2010. Changes of the glucidic metabolism determined by the physical effort of the treatment with the Aslavital and Apilarnil. Arad Med J, 13(3): 33-41.
- Komosinska-Vassev K, Olczyk P, Kaźmierczak J, Mencner L, Olczyk K. 2015. Bee Pollen: Chemical Composition and Therapeutic Application. Evidence-based Complement Alternat Med, 2015: 297425.
- Kowalski S, Makarewicz M. 2017. Functional properties of honey supplemented with bee bread and propolis. Natural Product Res, 31(22): 2680-2683.
- Kurek-Górecka A, Rzepecka-Stojko A, Górecki M, Stojko J, Sosada M, Świerczek-Zięba G. 2013. Structure and antioxidant activity of polyphenols derived from propolis. Molecules, 19(1): 78-101.
- Lotufo MA, Júnior CAL, Shimizu MT, Cabral R, Esther GB. 2005. Clinical evaluation of the topical use of propolis in recurrent minor aphthous ulceration. Cienc Odontol Bras, 8(3):6-9.
- Madras MK, Jasiński Z. 2005. The Content of Mercury in Bee Bread Originating From Different Region of Poland. J Apicultural Sci, 49(2): 69-73.
- Mijanur Rahman M, Gan SH, Khalil MDI. 2014. Neurological effects of honey: current and future prospects. Evidence-based Complement Alternat Med, 2014:958721.
- Nagai T, Inoue R. 2004. Preparation and the functional properties of water extract and alkaline extract of royal jelly. Food Chem, 84(2): 181-186.
- Nakaya M, Onda H, Sasaki K, Yukiyoshi A, Tachibana H, Yamada K. 2007. Effect of royal jelly on bisphenol A-induced proliferation of human breast cancer cells. Biosci Biotechnol Biochem, 71(1): 253-255.
- Özbek H. 1990. Bal Arısı (Apis mellifera L.) Zehiri. Atatürk Üniv Zir Fak Der, 21(2): 84 – 100.
- Özkan S, Bancar K. 2015. Apiterapi ve çocuk sağliği. Dokuz Eylül Üniv Hemşirelik Fak Derg, (4): 247-251.
- Paola F, Pantalea DD, Gianfranco C, Antonio F, Angelo V, Eustachio N, Elisabetta DL. 2014. Oral allergy syndrome in a child provoked by royal jelly. Case Reports in Medicine, 2014: 941248.
- Park MH, Choi MS, Kwak DH, Oh KW, Yoon DY, Han SB, Song HS, Song MJ, Hong JT. 2011. Anti-cancer effect of bee venom in prostate cancer cells through activation of caspase pathway via inactivation of NF-κB. The Prostate, 71( ): 01-812.
- Park YK, Alencar SM, Aguiar CL. 2002. Botanical origin and chemical composition of Brazilian propolis., J Agri Food Chem, 50(9): 2502-2506.
- Parolia A, Thomas MS, Kundabala M, Mohan M. 2010. Propolis and its potential uses in oral health. Inter J Medicine Medical Sci, 2(7): 210-215.
- Pasupuleti VR, Sammugam L, Ramesh N, Gan SH. 2017. Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits. Oxidative Medi Cellular Longevity, 2017(2): 1-21.
- Patel S. 2016. Emerging Adjuvant Therapy for Cancer: Propolis and its Constituents. J dietary supplements, 13(3): 245-268.
- Pifko E, Price A, Sterner S. 2014. Infant botulism and indications for administration of botulism immune globülin. Pediatric Emergency Care, 30(2): 120-124.
- Pimentel RB, da Costa CA, Albuquerque PM, Junior SD. 2013. Antimicrobial activity and rutin identification of honey produced by the stingless bee Melipona compressipes manaosensis and commercial honey. Evidence-based Complement Alternat Med, 13: 151.
- Rakha MK, Nabil ZI, Hussein AA. 2008. Cardioactive and vasoactive effects of natural wild honey against cardiac malperformance induced by hyperadrenergic activity. J Medicinal Food, 11(1): 91-98.
- Samarghandian S, Afshari JT, Davoodi S. 2011. Honey induces apoptosis in renal cell carcinoma. Pharmacognosy Magazine, 7(25): 46-52.
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Yıl 2021,
, 168 - 174, 01.05.2021
Gökçe Özdemir
,
Elmas Ersöz
,
Nazik Dilek
Öz
Apitherapy is a word derived from the Latin word apis, meaning bee. Apitherapy application dates back hundreds of years. There are documents showing that physicians in Ancient Egypt and China used some bee products 4 thousand years ago. Apitherapy is used as an effective method for maintaining health and treating diseases. The main products used in this method are honey, apilarnil, propolis, royal jelly and perga. These products used in apitherapy are generally known to have very important effects such as antibacterial, antioxidant, anti-inflammatory, vasodilating and antitumor effects. In addition to its positive effects, studies have shown that the use of some apitherapy products may cause an allergic reaction. As a result, the use of these nutrients obtained from reliable sources has beneficial effects on health.
Kaynakça
- Abd-El Aal AM, El-Hadidy MR, El-Mashad NB, El-Sebaie AH. 2007. Antimicrobial effect of bee honey in comparison to antibiotics on organisms isolated from infected burns. Ann Burns Fire Disasters, 20(2): 83-88.
- Abel SDA, Baird SK. 2018. Honey is cytotoxic towards prostate cancer cells but interacts with the MTT reagent: Considerations for the choice of cell viability assay. Food Chem, 241: 70-78.
- Abouda Z, Zerdani I, Kalalou I, Faid M, Ahami MJRJoM2011 The antibacterial activity of Moroccan bee bread and bee-pollen (fresh and dried) against pathogenic bacteria. Res J Microbiol, 6(4): 376-384.
- Afroz R, Tanvir E, Little PJC. 2016. Honey-derived flavonoids: natural products for the prevention of atherosclerosis and cardiovascular diseases. Clin Exper Pharmacol, 6(3): 1-4.
- Ajibola A, Chamunorwa JP, Erlwanger KH. 2012. Nutraceutical values of natural honey and its contribution to human health and wealth. Nutri Metabol, 9(1): 61.
- Ajibola A. 2015. Novel insights into the health importance of natural honey. The Malaysian J Med Sci, 22(5): 7-22.
- Akyol E. 2015. Structure of royal jelly, importance for humans and bees. Uludağ Arıcılık Derg, 15(1): 16-21.
- Altıntaş L, Bektaş N. 2019. Apiterapi: 1. Ari zehri. Uludag Bee J, 19(1): 82-95.
- Annav T, Mari J, Ioanna C, Konstadia G, Tiina T, Vesa V, Paraskevi M. 2009. Bioactivity of Greek honey extracts on breast cancer (MCF-7), prostate cancer (PC-3) and endometrial cancer (Ishikawa) cells: Profile analysis of extracts. Food Chem, 116(3):702-708.
- Annila IJC, Allergy E. 2000. Bee venom allergy. J British Soc Allergy Clin Immun, 30(12): 1682-1687.
- Attia WY, Gabry MS, El-Shaikh KA, Othman GA. 2008. The anti-tumor effect of bee honey in Ehrlich ascite tumor model of mice is coincided with stimulation of the immune cells. The Egyptian J Immunol, 15(2): 169-183.
- Aydın, Y, Tekeog lu. 201 . Tamamlayıcı tıp ve gu ncel apiterapı uygulamaları. J Biotechnol Strat Health Res, 2(2): 64-73.
- Bakour M, Fernandes Â, Barros L, Sokovic M, Ferreira ICFR, Badiaa l. 2019. Bee bread as a functional product: Chemical composition and bioactive properties. Food Sci Technol, 109: 276-282.
- Bangroo AK, Khatri R, Chauhan, S. 2005. Honey dressing in pediatric burns. J Indian Assoc Pediatric Surgeons, 10(3): 172-175.
- Bilsel Y, Bugra D, Yamaner S, Bulut T, Cevikbas U, Turkoglu U. 2002. Could honey have a place in colitis therapy? Effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation. Digestive Surgery, 19(4): 306-312.
- Bincoletto C, Eberlin S, Figueiredo CA, Luengo MB, Queiroz ML. 2005. Effects produced by Royal Jelly on haematopoiesis: relation with host resistance against Ehrlich ascites tumour challenge. Inter Immunopharmacol, 5(4): 679-88.
- Bogdanov S, Jurendic T, Sieber R, Gallmann P. 2008. Honey for nutrition and health: A review. J American College Nutri, 27(6): 677-689.
- Celimli N. 2004. Veteriner hekimlikte yara sağaltiminda bal kullanimi. Veteriner Cerrahi Derg, 10(3-4), 73-77.
- Choi CS, Park JK, An CG, Lee EH, Ahn KJ. 2015. Multiple benefits of bee venom in aged skin manifestations. Asian J Beauty Cosmetol, 13(5): 679-688.
- Çelik K, Aşgun HF. 2020. Arilarla gelen sağlık “apiterapi”. Tudás Alapítvány, İstanbul, Türkiye, pp. 104.
- Delavarian Z, Paakfetrat A, Nazari F, Tonekaboni A, Shakeri MT. 2015. An investigation of the effects propolis on the recurrent oral aphthous ulcers. Avicenna J Phytomed, 5(1): p113.
- Devagondanahalli HM, Suan CL. 2014. The anti-inflammatory and wound healing properties of honey. European Food Res Technol, 239(6), 1003-1014.
- Doğanyiğit Z, Okan A, Kaymak E, Pandır D, Silici S. 2020. Investigation of protective effects of apilarnil against lipopolysaccharide induced liver injury in rats via TLR 4/ HMGB-1/ NF-κB pathway. Biomed Pharmacotherapy, 125: 109967.
- Erdem B, Özkök A. 201 . Can Food Supplement Produced from Apilarnil be an Alternative to Testosterone Replacement Therapy? Hacettepe J Biology Chem, 45(4): 635-638.
- Gekker G, Hu S, Spivak M, Lokensgard JR, Peterson PK. 2005. Anti-HIV-1 activity of propolis in CD4+ lymphocyte and microglial cell cultures. J Ethnopharmacology, 102(2): 158-163.
- Hamamcı M, Doganyigit Z, Silici S, Okan A, Kaymak E, Yilmaz S, Tokpinar A, Inan LE. 2020. Apilarnil: A Novel Neuroprotective Candidate. Acta Neurologica Taiwanica, 29(2): 33-45.
- Han X, Shen T, Lou H. 2007. Dietary polyphenols and their biological significance. Inter J Molec Sci, 8(9): 950-988.
- Harish Z, Rubinstein A, Golodner M, Elmaliah M, Mizrachi Y. 1997. Suppression of HIV-1 replication by propolis and its immunoregulatory effect. Drugs Under Experiment Clinical Res, 23(2), 89-96.
- Hassan MI, Mabrouk GM, Shehata HH, Aboelhussein MM. 2012. Antineoplastic effects of bee honey and Nigella sativa on hepatocellular carcinoma cells. Integrative Cancer Therapies, 11(4), 354-363.
- Hidaka S, Okamoto Y, Uchiyama S, Nakatsuma A, Hashimoto K, Ohnishi ST, Yamaguchi M. 2006. Royal jelly prevents osteoporosis in rats: beneficial effects in ovariectomy model and in bone tissue culture model. Evidence-based Complement Alternat Med, 3(3): 339-348.
- Israili ZH. 2014. Antimicrobial properties of honey. American J Therapeutics, 21(4): 304-323.
- Ito J, Chang FR, Wang HK, Park YK, Ikegaki M, Kilgore N, Lee KH. 2001. Anti-AIDS agents48Anti-HIV activity of moronic acid derivatives and the new melliferone-related triterpenoid isolated from Brazilian propolis. J Natural Products, 64(10): 1278-1281.
- Jo M, Park MH, Kollipara PS, An BJ, Song HS, Han SB, Kim JH, Song MJ, Hong JT. 2012. Anti-cancer effect of bee venom toxin and melittin in ovarian cancer cells through induction of death receptors and inhibition of JAK2/STAT3 pathway. Toxicology Applied Pharmacolog, 258(1): 72-81.
- Karaman M, Artık N, Küçükersan K, Halıcı Z, Çelik M. 2016. Perga (Bee Bread) composition and health benefit. In: Proceedings of 2nd Inter Turkic World Conference on Chemical Sci Technologies, April 01-30,Turkey.
- Khalifa SAM, Elashal M, Kieliszek M, Ghazala NE, Farag MA, Saeed A, Xiao J, boZou Z, Khatib A, Göransson U, El-Seedi HR. 2020. Recent insights into chemical and pharmacological studies of bee bread. Trends Food Sci Technol, 97: 300-316.
- Kim S, Hong I, Woo S, Jang H, Pak S, Han S. 2017. Isolation of Abscisic Acid from Korean Acacia Honey with Anti-Helicobacter pylori Activity. Pharmacognosy Magazine, 13(2): 170-173.
- Kogalniceanu S, Lancrajan I, Ardelean G. 2010. Changes of the glucidic metabolism determined by the physical effort of the treatment with the Aslavital and Apilarnil. Arad Med J, 13(3): 33-41.
- Komosinska-Vassev K, Olczyk P, Kaźmierczak J, Mencner L, Olczyk K. 2015. Bee Pollen: Chemical Composition and Therapeutic Application. Evidence-based Complement Alternat Med, 2015: 297425.
- Kowalski S, Makarewicz M. 2017. Functional properties of honey supplemented with bee bread and propolis. Natural Product Res, 31(22): 2680-2683.
- Kurek-Górecka A, Rzepecka-Stojko A, Górecki M, Stojko J, Sosada M, Świerczek-Zięba G. 2013. Structure and antioxidant activity of polyphenols derived from propolis. Molecules, 19(1): 78-101.
- Lotufo MA, Júnior CAL, Shimizu MT, Cabral R, Esther GB. 2005. Clinical evaluation of the topical use of propolis in recurrent minor aphthous ulceration. Cienc Odontol Bras, 8(3):6-9.
- Madras MK, Jasiński Z. 2005. The Content of Mercury in Bee Bread Originating From Different Region of Poland. J Apicultural Sci, 49(2): 69-73.
- Mijanur Rahman M, Gan SH, Khalil MDI. 2014. Neurological effects of honey: current and future prospects. Evidence-based Complement Alternat Med, 2014:958721.
- Nagai T, Inoue R. 2004. Preparation and the functional properties of water extract and alkaline extract of royal jelly. Food Chem, 84(2): 181-186.
- Nakaya M, Onda H, Sasaki K, Yukiyoshi A, Tachibana H, Yamada K. 2007. Effect of royal jelly on bisphenol A-induced proliferation of human breast cancer cells. Biosci Biotechnol Biochem, 71(1): 253-255.
- Özbek H. 1990. Bal Arısı (Apis mellifera L.) Zehiri. Atatürk Üniv Zir Fak Der, 21(2): 84 – 100.
- Özkan S, Bancar K. 2015. Apiterapi ve çocuk sağliği. Dokuz Eylül Üniv Hemşirelik Fak Derg, (4): 247-251.
- Paola F, Pantalea DD, Gianfranco C, Antonio F, Angelo V, Eustachio N, Elisabetta DL. 2014. Oral allergy syndrome in a child provoked by royal jelly. Case Reports in Medicine, 2014: 941248.
- Park MH, Choi MS, Kwak DH, Oh KW, Yoon DY, Han SB, Song HS, Song MJ, Hong JT. 2011. Anti-cancer effect of bee venom in prostate cancer cells through activation of caspase pathway via inactivation of NF-κB. The Prostate, 71( ): 01-812.
- Park YK, Alencar SM, Aguiar CL. 2002. Botanical origin and chemical composition of Brazilian propolis., J Agri Food Chem, 50(9): 2502-2506.
- Parolia A, Thomas MS, Kundabala M, Mohan M. 2010. Propolis and its potential uses in oral health. Inter J Medicine Medical Sci, 2(7): 210-215.
- Pasupuleti VR, Sammugam L, Ramesh N, Gan SH. 2017. Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits. Oxidative Medi Cellular Longevity, 2017(2): 1-21.
- Patel S. 2016. Emerging Adjuvant Therapy for Cancer: Propolis and its Constituents. J dietary supplements, 13(3): 245-268.
- Pifko E, Price A, Sterner S. 2014. Infant botulism and indications for administration of botulism immune globülin. Pediatric Emergency Care, 30(2): 120-124.
- Pimentel RB, da Costa CA, Albuquerque PM, Junior SD. 2013. Antimicrobial activity and rutin identification of honey produced by the stingless bee Melipona compressipes manaosensis and commercial honey. Evidence-based Complement Alternat Med, 13: 151.
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