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Yıl 2024, Cilt: 16 Sayı: 2, 33 - 40, 31.12.2024

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Kaynakça

  • Ahmad, T., Masoodi, F. A., A. Rather, S., Wani, S. M., & Gull, A. (2019). Supercritical Fluid Extraction: A Review. Journal of Biological and Chemical Chronicles, 5(1), 114–122. https://doi.org/10.33980/jbcc.2019.v05i01.019
  • Amaral, G. V., Silva, E. K., Cavalcanti, R. N., Cappato, L. P., Guimaraes, J. T., Alvarenga, V. O., Esmerino, E. A., Portela, J. B., Sant’ Ana, A. S., Freitas, M. Q., Silva, M. C., Raices, R. S. L., Meireles, M. A. A., & Cruz, A. G. (2017). Dairy processing using supercritical carbon dioxide technology: Theoretical fundamentals, quality and safety aspects. Trends in Food Science and Technology, 64, 94–101. https://doi.org/10.1016/j.tifs.2017.04.004
  • Anonymus (2001). Regulation of Bee Products. Ministério Da Agricultura E Do Abastecimento Secretaria De Defesa Agropecuária Instrução Normativa.
  • Anonymus (2024). Türk Gıda Kodeksi Arı Ürünleri Tebliği ham propolis ve propolis ürünleri tebliği. Turkish Food Legislation Bee Products Regulation, 2.
  • Baiker, A. (1999). Supercritical Fluids in Heterogeneous Catalysis. Chemical Reviews, 99(2), 453–474. https://doi.org/10.1021/cr970090z
  • Banskota, A. H., Tezuka, Y., & Kadota, S. (2001). Recent progress in pharmacological research of propolis. Phytotherapy Research, 15(7), 561–571. https://doi.org/10.1002/ptr.1029
  • Biscaia, D., & Ferreira, S. R. S. (2009). Propolis extracts obtained by low pressure methods and supercritical fluid extraction. Journal of Supercritical Fluids, 51(1), 17–23. https://doi.org/10.1016/j.supflu.2009.07.011
  • Catchpole, O. J., Grey, J. B., Mitchell, K. A., & Lan, J. S. (2004). Supercritical antisolvent fractionation of propolis tincture. Journal of Supercritical Fluids, 29(1–2), 97–106. https://doi.org/10.1016/S0896-8446(03)00033-0
  • Chen, C. R., Lee, Y. N., Lee, M. R., & Chang, C. M. J. (2009). Supercritical fluids extraction of cinnamic acid derivatives from Brazilian propolis and the effect on growth inhibition of colon cancer cells. Journal of the Taiwan Institute of Chemical Engineers, 40(2), 130–135. https://doi.org/10.1016/j.jtice.2008.07.014
  • Chen, F., Chen, L., Wang, Q., Zhou, J., Xue, X., & Zhao, J. (2009). Determination of organochlorine pesticides in propolis by gas chromatography-electron capture detection using double column series solid-phase extraction. Analytical and Bioanalytical Chemistry, 393(3), 1073–1079. https://doi.org/10.1007/s00216-008-2474-1
  • Dantas Silva, R. P., Machado, B. A. S., Barreto, G. de A., Costa, S. S., Andrade, L. N., Amaral, R. G., Carvalho, A. A., Padilha, F. F., Barbosa, J. D. V., & Umsza-Guez, M. A. (2017). Antioxidant, antimicrobial, antiparasitic, and cytotoxic properties of various Brazilian propolis extracts. PLOS ONE, 12(3), e0172585. https://doi.org/10.1371/journal.pone.0172585
  • De Zordi, N., Cortesi, A., Kikic, I., Moneghini, M., Solinas, D., Innocenti, G., Portolan, A., Baratto, G., & Dall’Acqua, S. (2014). The supercritical carbon dioxide extraction of polyphenols from Propolis: A central composite design approach. Journal of Supercritical Fluids, 95, 491–498. https://doi.org/10.1016/j.supflu.2014.10.006
  • Devequi-Nunes, D., Machado, B. A. S., De Abreu Barreto, G., Silva, J. R., Da Silva, D. F., Da Rocha, J. L. C., Brandão, H. N., Borges, V. M., & Umsza-Guez, M. A. (2018). Chemical characterization and biological activity of six different extracts of propolis through conventional methods and supercritical extraction. PLoS ONE, 13(12). https://doi.org/10.1371/journal.pone.0207676
  • Fachri, B. A., Sari, P., Yuwanti, S., & Subroto, E. (2020). Experimental study and modeling on supercritical CO2 extraction of Indonesian raw propolis using response surface method: Influence of pressure, temperature and CO2 mass flowrate on extraction yield. Chemical Engineering Research and Design, 153, 452–462. https://doi.org/10.1016/j.cherd.2019.11.014
  • Ghisalberti, E. L. (1979). Propolis: A Review. Bee World, 60(2), 59–84. https://doi.org/10.1080/0005772x.1979.11097738
  • Herrero, M., Mendiola, J. A., Cifuentes, A., & Ibáñez, E. (2010). Supercritical fluid extraction: Recent advances and applications. Journal of Chromatography A, 1217(16), 2495–2511. https://doi.org/10.1016/j.chroma.2009.12.019
  • Joana Gil-Chávez, G., Villa, J. A., Fernando Ayala-Zavala, J., Basilio Heredia, J., Sepulveda, D., Yahia, E. M., & González-Aguilar, G. A. (2013). Technologies for Extraction and Production of Bioactive Compounds to be Used as Nutraceuticals and Food Ingredients: An Overview. Comprehensive Reviews in Food Science and Food Safety, 12(1), 5–23. https://doi.org/10.1111/1541-4337.12005
  • Lee, Y. N., Chen, C. R., Yang, H. L., Lin, C. C., & Chang, C. M. J. (2007). Isolation and purification of 3,5-diprenyl-4-hydroxycinnamic acid (artepillin C) in Brazilian propolis by supercritical fluid extractions. Separation and Purification Technology, 54(1), 130–138. https://doi.org/10.1016/j.seppur.2006.08.028
  • Machado, B. A. S., De Abreu Barreto, G., Costa, A. S., Costa, S. S., Silva, R. P. D., Da Silva, D. F., Brandao, H. N., Da Rocha, J. L. C., Nunes, S. B., Umsza-Guez, M. A., & Padilha, F. F. (2015). Determination of parameters for the supercritical extraction of antioxidant compounds from green propolis using carbon dioxide and ethanol as co-solvent. PLoS ONE, 10(8). https://doi.org/10.1371/journal.pone.0134489
  • Machado, B. A. S., De Oliveira Reis, J. H., De Souza, A. L. B., Druzian, J. I., & Pessoa, F. L. P. (2019). Extraction of propolis using supercritical carbon dioxide. In Green Sustainable Process for Chemical and Environmental Engineering and Science: Supercritical Carbon Dioxide as Green Solvent. Elsevier. https://doi.org/10.1016/B978-0-12-817388-6.00009-X
  • Machado, B. A. S., Silva, R. P. D., Barreto, G. D. A., Costa, S. S., Da Silva, D. F., Brandão, H. N., Da Rocha, J. L. C., Dellagostin, O. A., Henriques, J. A. P., Umsza-Guez, M. A., & Padilha, F. F. (2016). Chemical composition and biological activity of extracts obtained by supercritical extraction and ethanolic extraction of brown, green and red propolis derived from different geographic regions in Brazil. PLoS ONE, 11(1). https://doi.org/10.1371/journal.pone.0145954
  • Margeretha, I., Fatma Suniarti, D., Herda, E., & Mas’ud, Z. A. (2012). Optimization and comparative study of different extraction methods of biologically active components of Indonesian propolis Trigona spp. Journal of Natural Products, 5, 233–242.
  • Monroy, Y. M., Rodrigues, R. A. F., Rodrigues, M. V. N., Sant’Ana, A. S., Silva, B. S., & Cabral, F. A. (2017). Brazilian green propolis extracts obtained by conventional processes and by processes at high pressure with supercritical carbon dioxide, ethanol and water. Journal of Supercritical Fluids, 130, 189–197. https://doi.org/10.1016/j.supflu.2017.08.006
  • Monroy, Y. M., Rodrigues, R. A. F., Rodrigues, M. V. N., Sartoratto, A., & Cabral, F. A. (2022). Supercritical extraction from red propolis and fractionation of its hydroalcoholic and ethanolic extracts using CO2 as anti-solvent. Brazilian Journal of Development, 8(1), 8032–8046. https://doi.org/10.34117/bjdv8n1-539
  • Novak, E. M., Silva, M. S. e. C., Marcucci, M. C., Sawaya, A. C. H. F., Giménez-Cassina López, B., Fortes, M. A. H. Z., Giorgi, R. R., Marumo, K. T., Rodrigues, R. F., & Maria, D. A. (2014). Antitumoural activity of Brazilian red propolis fraction enriched with xanthochymol and formononetin: An in vitro and in vivo study. Journal of Functional Foods, 11(C), 91–102. https://doi.org/10.1016/j.jff.2014.09.008
  • Paviani, L. C., Dariva, C., Marcucci, M. C., & Cabral, F. A. (2010). Supercritical carbon dioxide selectivity to fractionate phenolic compounds from the dry ethanolic extract of propolis. Journal of Food Process Engineering, 33(1), 15–27. https://doi.org/10.1111/j.1745-4530.2008.00256.x
  • Paviani, L. C., Fiorito, G., Sacoda, P., & Cabral, F. A. (2013). Different Solvents for Extraction of Brazilian Green Propolis: Composition and Extraction Yield of Phenolic Compounds. III Iberoamerican Conference on Supercritical Fluids, 1–5.
  • Pereda, S., Bottini, S. B., & Brignole, E. A. (2005). Supercritical fluids and phase behavior in heterogeneous gas-liquid catalytic reactions. Applied Catalysis A: General, 281(1–2), 129–137. https://doi.org/10.1016/j.apcata.2004.11.019
  • Pimentel-Moral, S., Borrás-Linares, I., Lozano-Sánchez, J., Arráez-Román, D., Martínez-Férez, A., & Segura-Carretero, A. (2019). Supercritical CO2 extraction of bioactive compounds from Hibiscus sabdariffa. Journal of Supercritical Fluids, 147, 213–221. https://doi.org/10.1016/j.supflu.2018.11.005
  • Reis, J. H. de O., Machado, B. A. S., Barreto, G. de A., Anjos, J. P. Dos, Fonseca, L. M. D. S., Santos, A. A. B., Pessoa, F. L. P., & Druzian, J. I. (2020). Supercritical Extraction of Red Propolis: Operational Conditions and Chemical Characterization. Molecules, 25(20). https://doi.org/10.3390/molecules25204816
  • Reverchon, E., & De Marco, I. (2006). Supercritical fluid extraction and fractionation of natural matter. Journal of Supercritical Fluids, 38(2), 146–166. https://doi.org/10.1016/j.supflu.2006.03.020
  • Saito, É., Sacoda, P., Paviani, L. C., Paula, J. T., & Cabral, F. A. (2021). Conventional and supercritical extraction of phenolic compounds from Brazilian red and green propolis. Separation Science and Technology (Philadelphia), 56(18), 3119–3126. https://doi.org/10.1080/01496395.2020.1731755
  • Salleh, L. (2012). Optimization of Extraction Condition for Supercritical Carbon Dioxide (SCCO 2) Extraction of Strobhilantes crispus (Pecah Kaca) Leaves by Response Surface Methodology. Journal of Food Processing & Technology, 04(01). https://doi.org/10.4172/2157-7110.1000197
  • Sonverdi, A., Sonverdi, F., Altuntaş, Ü., & Özçelik, B. (2024). Determination of Total Phenolic Compounds and Antioxidant Activity of Turkish Propolis Extracted by Different Methods. ITU Journal of Food Science and Technology, 2(1), 41–46.
  • Souza, A. R. C., Guedes, A. R., Folador Rodriguez, J. M., Bombardelli, M. C. M., & Corazza, M. L. (2018). Extraction of Arctium Lappa leaves using supercritical CO2 + ethanol: Kinetics, chemical composition, and bioactivity assessments. Journal of Supercritical Fluids, 140, 137–146. https://doi.org/10.1016/j.supflu.2018.06.011
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  • Zhang, H., Fu, Y., Niu, F., Li, Z., Ba, C., Jin, B., Chen, G., & Li, X. (2018). Enhanced antioxidant activity and in vitro release of propolis by acid-induced aggregation using heat-denatured zein and carboxymethyl chitosan. Food Hydrocolloids, 81, 104–112. https://doi.org/10.1016/j.foodhyd.2018.02.019
  • Zhang, X., Heinonen, S., & Levänen, E. (2014). Applications of supercritical carbon dioxide in materials processing and synthesis. RSC Advances, 4(105), 61137–61152. https://doi.org/10.1039/c4ra10662h97(4), 123–127. https://doi.org/10.1080/0005772x.2020.1763086

A Novel Approach on Propolis Extraction: Supercritical Carbon Dioxide Extraction, Advantages and Disadvantages

Yıl 2024, Cilt: 16 Sayı: 2, 33 - 40, 31.12.2024

Öz

Propolis is a unique bee product rich in bioactive compounds. The natural structure of propolis is resinous and waxy, which makes it indigestable for humans. Extraction process is a neccessity in order to obtain bioactive compounds of propolis. Ethanolic maceration is one of the most employed methods for propolis extraction. However, this method has some shortcomings, such as solvent residue, dark coloration, and a lenghty process. To eliminate these shortcomings, new and environmentally friendly technologies are also employed. Supercritical carbon dioxide extraction is one such method. This method has been increasingly employed in recent years. This review highlights properties, advantages, and disadvantages of supercritical carbon dioxide extraction.

Etik Beyan

There are no ethical issues with the publication of this article.

Kaynakça

  • Ahmad, T., Masoodi, F. A., A. Rather, S., Wani, S. M., & Gull, A. (2019). Supercritical Fluid Extraction: A Review. Journal of Biological and Chemical Chronicles, 5(1), 114–122. https://doi.org/10.33980/jbcc.2019.v05i01.019
  • Amaral, G. V., Silva, E. K., Cavalcanti, R. N., Cappato, L. P., Guimaraes, J. T., Alvarenga, V. O., Esmerino, E. A., Portela, J. B., Sant’ Ana, A. S., Freitas, M. Q., Silva, M. C., Raices, R. S. L., Meireles, M. A. A., & Cruz, A. G. (2017). Dairy processing using supercritical carbon dioxide technology: Theoretical fundamentals, quality and safety aspects. Trends in Food Science and Technology, 64, 94–101. https://doi.org/10.1016/j.tifs.2017.04.004
  • Anonymus (2001). Regulation of Bee Products. Ministério Da Agricultura E Do Abastecimento Secretaria De Defesa Agropecuária Instrução Normativa.
  • Anonymus (2024). Türk Gıda Kodeksi Arı Ürünleri Tebliği ham propolis ve propolis ürünleri tebliği. Turkish Food Legislation Bee Products Regulation, 2.
  • Baiker, A. (1999). Supercritical Fluids in Heterogeneous Catalysis. Chemical Reviews, 99(2), 453–474. https://doi.org/10.1021/cr970090z
  • Banskota, A. H., Tezuka, Y., & Kadota, S. (2001). Recent progress in pharmacological research of propolis. Phytotherapy Research, 15(7), 561–571. https://doi.org/10.1002/ptr.1029
  • Biscaia, D., & Ferreira, S. R. S. (2009). Propolis extracts obtained by low pressure methods and supercritical fluid extraction. Journal of Supercritical Fluids, 51(1), 17–23. https://doi.org/10.1016/j.supflu.2009.07.011
  • Catchpole, O. J., Grey, J. B., Mitchell, K. A., & Lan, J. S. (2004). Supercritical antisolvent fractionation of propolis tincture. Journal of Supercritical Fluids, 29(1–2), 97–106. https://doi.org/10.1016/S0896-8446(03)00033-0
  • Chen, C. R., Lee, Y. N., Lee, M. R., & Chang, C. M. J. (2009). Supercritical fluids extraction of cinnamic acid derivatives from Brazilian propolis and the effect on growth inhibition of colon cancer cells. Journal of the Taiwan Institute of Chemical Engineers, 40(2), 130–135. https://doi.org/10.1016/j.jtice.2008.07.014
  • Chen, F., Chen, L., Wang, Q., Zhou, J., Xue, X., & Zhao, J. (2009). Determination of organochlorine pesticides in propolis by gas chromatography-electron capture detection using double column series solid-phase extraction. Analytical and Bioanalytical Chemistry, 393(3), 1073–1079. https://doi.org/10.1007/s00216-008-2474-1
  • Dantas Silva, R. P., Machado, B. A. S., Barreto, G. de A., Costa, S. S., Andrade, L. N., Amaral, R. G., Carvalho, A. A., Padilha, F. F., Barbosa, J. D. V., & Umsza-Guez, M. A. (2017). Antioxidant, antimicrobial, antiparasitic, and cytotoxic properties of various Brazilian propolis extracts. PLOS ONE, 12(3), e0172585. https://doi.org/10.1371/journal.pone.0172585
  • De Zordi, N., Cortesi, A., Kikic, I., Moneghini, M., Solinas, D., Innocenti, G., Portolan, A., Baratto, G., & Dall’Acqua, S. (2014). The supercritical carbon dioxide extraction of polyphenols from Propolis: A central composite design approach. Journal of Supercritical Fluids, 95, 491–498. https://doi.org/10.1016/j.supflu.2014.10.006
  • Devequi-Nunes, D., Machado, B. A. S., De Abreu Barreto, G., Silva, J. R., Da Silva, D. F., Da Rocha, J. L. C., Brandão, H. N., Borges, V. M., & Umsza-Guez, M. A. (2018). Chemical characterization and biological activity of six different extracts of propolis through conventional methods and supercritical extraction. PLoS ONE, 13(12). https://doi.org/10.1371/journal.pone.0207676
  • Fachri, B. A., Sari, P., Yuwanti, S., & Subroto, E. (2020). Experimental study and modeling on supercritical CO2 extraction of Indonesian raw propolis using response surface method: Influence of pressure, temperature and CO2 mass flowrate on extraction yield. Chemical Engineering Research and Design, 153, 452–462. https://doi.org/10.1016/j.cherd.2019.11.014
  • Ghisalberti, E. L. (1979). Propolis: A Review. Bee World, 60(2), 59–84. https://doi.org/10.1080/0005772x.1979.11097738
  • Herrero, M., Mendiola, J. A., Cifuentes, A., & Ibáñez, E. (2010). Supercritical fluid extraction: Recent advances and applications. Journal of Chromatography A, 1217(16), 2495–2511. https://doi.org/10.1016/j.chroma.2009.12.019
  • Joana Gil-Chávez, G., Villa, J. A., Fernando Ayala-Zavala, J., Basilio Heredia, J., Sepulveda, D., Yahia, E. M., & González-Aguilar, G. A. (2013). Technologies for Extraction and Production of Bioactive Compounds to be Used as Nutraceuticals and Food Ingredients: An Overview. Comprehensive Reviews in Food Science and Food Safety, 12(1), 5–23. https://doi.org/10.1111/1541-4337.12005
  • Lee, Y. N., Chen, C. R., Yang, H. L., Lin, C. C., & Chang, C. M. J. (2007). Isolation and purification of 3,5-diprenyl-4-hydroxycinnamic acid (artepillin C) in Brazilian propolis by supercritical fluid extractions. Separation and Purification Technology, 54(1), 130–138. https://doi.org/10.1016/j.seppur.2006.08.028
  • Machado, B. A. S., De Abreu Barreto, G., Costa, A. S., Costa, S. S., Silva, R. P. D., Da Silva, D. F., Brandao, H. N., Da Rocha, J. L. C., Nunes, S. B., Umsza-Guez, M. A., & Padilha, F. F. (2015). Determination of parameters for the supercritical extraction of antioxidant compounds from green propolis using carbon dioxide and ethanol as co-solvent. PLoS ONE, 10(8). https://doi.org/10.1371/journal.pone.0134489
  • Machado, B. A. S., De Oliveira Reis, J. H., De Souza, A. L. B., Druzian, J. I., & Pessoa, F. L. P. (2019). Extraction of propolis using supercritical carbon dioxide. In Green Sustainable Process for Chemical and Environmental Engineering and Science: Supercritical Carbon Dioxide as Green Solvent. Elsevier. https://doi.org/10.1016/B978-0-12-817388-6.00009-X
  • Machado, B. A. S., Silva, R. P. D., Barreto, G. D. A., Costa, S. S., Da Silva, D. F., Brandão, H. N., Da Rocha, J. L. C., Dellagostin, O. A., Henriques, J. A. P., Umsza-Guez, M. A., & Padilha, F. F. (2016). Chemical composition and biological activity of extracts obtained by supercritical extraction and ethanolic extraction of brown, green and red propolis derived from different geographic regions in Brazil. PLoS ONE, 11(1). https://doi.org/10.1371/journal.pone.0145954
  • Margeretha, I., Fatma Suniarti, D., Herda, E., & Mas’ud, Z. A. (2012). Optimization and comparative study of different extraction methods of biologically active components of Indonesian propolis Trigona spp. Journal of Natural Products, 5, 233–242.
  • Monroy, Y. M., Rodrigues, R. A. F., Rodrigues, M. V. N., Sant’Ana, A. S., Silva, B. S., & Cabral, F. A. (2017). Brazilian green propolis extracts obtained by conventional processes and by processes at high pressure with supercritical carbon dioxide, ethanol and water. Journal of Supercritical Fluids, 130, 189–197. https://doi.org/10.1016/j.supflu.2017.08.006
  • Monroy, Y. M., Rodrigues, R. A. F., Rodrigues, M. V. N., Sartoratto, A., & Cabral, F. A. (2022). Supercritical extraction from red propolis and fractionation of its hydroalcoholic and ethanolic extracts using CO2 as anti-solvent. Brazilian Journal of Development, 8(1), 8032–8046. https://doi.org/10.34117/bjdv8n1-539
  • Novak, E. M., Silva, M. S. e. C., Marcucci, M. C., Sawaya, A. C. H. F., Giménez-Cassina López, B., Fortes, M. A. H. Z., Giorgi, R. R., Marumo, K. T., Rodrigues, R. F., & Maria, D. A. (2014). Antitumoural activity of Brazilian red propolis fraction enriched with xanthochymol and formononetin: An in vitro and in vivo study. Journal of Functional Foods, 11(C), 91–102. https://doi.org/10.1016/j.jff.2014.09.008
  • Paviani, L. C., Dariva, C., Marcucci, M. C., & Cabral, F. A. (2010). Supercritical carbon dioxide selectivity to fractionate phenolic compounds from the dry ethanolic extract of propolis. Journal of Food Process Engineering, 33(1), 15–27. https://doi.org/10.1111/j.1745-4530.2008.00256.x
  • Paviani, L. C., Fiorito, G., Sacoda, P., & Cabral, F. A. (2013). Different Solvents for Extraction of Brazilian Green Propolis: Composition and Extraction Yield of Phenolic Compounds. III Iberoamerican Conference on Supercritical Fluids, 1–5.
  • Pereda, S., Bottini, S. B., & Brignole, E. A. (2005). Supercritical fluids and phase behavior in heterogeneous gas-liquid catalytic reactions. Applied Catalysis A: General, 281(1–2), 129–137. https://doi.org/10.1016/j.apcata.2004.11.019
  • Pimentel-Moral, S., Borrás-Linares, I., Lozano-Sánchez, J., Arráez-Román, D., Martínez-Férez, A., & Segura-Carretero, A. (2019). Supercritical CO2 extraction of bioactive compounds from Hibiscus sabdariffa. Journal of Supercritical Fluids, 147, 213–221. https://doi.org/10.1016/j.supflu.2018.11.005
  • Reis, J. H. de O., Machado, B. A. S., Barreto, G. de A., Anjos, J. P. Dos, Fonseca, L. M. D. S., Santos, A. A. B., Pessoa, F. L. P., & Druzian, J. I. (2020). Supercritical Extraction of Red Propolis: Operational Conditions and Chemical Characterization. Molecules, 25(20). https://doi.org/10.3390/molecules25204816
  • Reverchon, E., & De Marco, I. (2006). Supercritical fluid extraction and fractionation of natural matter. Journal of Supercritical Fluids, 38(2), 146–166. https://doi.org/10.1016/j.supflu.2006.03.020
  • Saito, É., Sacoda, P., Paviani, L. C., Paula, J. T., & Cabral, F. A. (2021). Conventional and supercritical extraction of phenolic compounds from Brazilian red and green propolis. Separation Science and Technology (Philadelphia), 56(18), 3119–3126. https://doi.org/10.1080/01496395.2020.1731755
  • Salleh, L. (2012). Optimization of Extraction Condition for Supercritical Carbon Dioxide (SCCO 2) Extraction of Strobhilantes crispus (Pecah Kaca) Leaves by Response Surface Methodology. Journal of Food Processing & Technology, 04(01). https://doi.org/10.4172/2157-7110.1000197
  • Sonverdi, A., Sonverdi, F., Altuntaş, Ü., & Özçelik, B. (2024). Determination of Total Phenolic Compounds and Antioxidant Activity of Turkish Propolis Extracted by Different Methods. ITU Journal of Food Science and Technology, 2(1), 41–46.
  • Souza, A. R. C., Guedes, A. R., Folador Rodriguez, J. M., Bombardelli, M. C. M., & Corazza, M. L. (2018). Extraction of Arctium Lappa leaves using supercritical CO2 + ethanol: Kinetics, chemical composition, and bioactivity assessments. Journal of Supercritical Fluids, 140, 137–146. https://doi.org/10.1016/j.supflu.2018.06.011
  • Stahl, E., Quirin, K.-W., & Gerard, D. (1988). Applications of Dense Gases to Extraction and Refining. In Dense Gases for Extraction and Refining (pp. 72–217). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-642-72892-1_4
  • Sun, J., Mu, Y., Shi, J., Zhao, Y., & Xu, B. (2022). Super/subcritical fluid extraction combined with ultrasound-assisted ethanol extraction in propolis development. Journal of Apicultural Research, 61(2), 255–263. https://doi.org/10.1080/00218839.2020.1772529
  • Temelli, F., Saldaña, M. D. A., & Comin, L. (2012). Application of supercritical fluid extraction in food processing. Comprehensive Sampling and Sample Preparation: Analytical Techniques for Scientists, 4, 415–440. https://doi.org/10.1016/B978-0-12-381373-2.00142-3
  • Tirado, D. F., Tenorio, M. J., Cabañas, A., & Calvo, L. (2018). Prediction of the best cosolvents to solubilise fatty acids in supercritical CO2 using the Hansen solubility theory. Chemical Engineering Science, 190, 14–20. https://doi.org/10.1016/j.ces.2018.06.017
  • Wang, B., Yang, J., Cicalo, J., Ivanov, A., & Zorian, Y. (2003). Supercritical fluid extractive fractionation – study of the antioxidant activities of propolis. Proceedings of the IEEE VLSI Test Symposium, 237–242. https://doi.org/10.1016/j.foodchem.2003.09.031
  • Wu, J. J., Shen, C. T., Jong, T. T., Young, C. C., Yang, H. L., Hsu, S. L., Chang, C. ming J., & Shieh, C. J. (2009). Supercritical carbon dioxide anti-solvent process for purification of micronized propolis particulates and associated anti-cancer activity. Separation and Purification Technology, 70(2), 190–198. https://doi.org/10.1016/j.seppur.2009.09.015
  • Yuan, Y., Zheng, S., Zeng, L., Deng, Z., Zhang, B., & Li, H. (2019). The Phenolic Compounds, Metabolites, and Antioxidant Activity of Propolis Extracted by Ultrasound-Assisted Method. Journal of Food Science, 84(12), 3850–3865. https://doi.org/10.1111/1750-3841.14934
  • Zhang, H., Fu, Y., Niu, F., Li, Z., Ba, C., Jin, B., Chen, G., & Li, X. (2018). Enhanced antioxidant activity and in vitro release of propolis by acid-induced aggregation using heat-denatured zein and carboxymethyl chitosan. Food Hydrocolloids, 81, 104–112. https://doi.org/10.1016/j.foodhyd.2018.02.019
  • Zhang, X., Heinonen, S., & Levänen, E. (2014). Applications of supercritical carbon dioxide in materials processing and synthesis. RSC Advances, 4(105), 61137–61152. https://doi.org/10.1039/c4ra10662h97(4), 123–127. https://doi.org/10.1080/0005772x.2020.1763086
Toplam 44 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Gıda Bilimleri (Diğer)
Bölüm Review
Yazarlar

Burak Hangişi Bu kişi benim 0000-0002-7125-1216

Yayımlanma Tarihi 31 Aralık 2024
Gönderilme Tarihi 25 Kasım 2024
Kabul Tarihi 24 Aralık 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 16 Sayı: 2

Kaynak Göster

APA Hangişi, B. (2024). A Novel Approach on Propolis Extraction: Supercritical Carbon Dioxide Extraction, Advantages and Disadvantages. Bee Studies, 16(2), 33-40.