Su, Tuz, Hipokloröz Asit ve Enfeksiyonlardan Korunma

Öz

Canlılar için hayatın devamı, belirli kimyasalların uygun oranlarda ve uygun zamanlarda alımına bağlıdır. Bu kimyasallar; gıdalar, su ve hava ile alınabilmektedir. Dünyanın büyük bir bölümü su içerdiği gibi canlı organizmalarda da yüksek oranda su bulunmaktadır. Organizmalarda yüksek oranda suyun varlığı kimyasal reaksiyonların büyük bir kısmının da sulu çözeltilerde olmasını sağlamaktadır. Canlılar kendi organizmasının bütünlüğünü koruma adına farklı savunma mekanizmaları kullanmaktadır. Enfeksiyon etkenlerinin yok edilmesinde antimikrobiyal etkinlik açısıdan savunma hücreleri önemli bir yere sahiptir. Nötrofiller, myeloperoksidaz aracılığı ile Hipokloröz asit (HOCl) oluşturarak antimikrobiyal aktivite göstermektedir. Savunma sisteminin doğal olarak ürettiği HOCl, yapay olarak da üretilerek temizlik ve dezenfeksiyon amacıyla kullanılabilmektedir. HOCl; su ve NaCl’nin elektrolizi ile üretilebildiği için ekonomiktir. Temizlik ve dezenfeksiyonda maksimum antimikrobiyal etkiye pH=3-6 seviyelerinde ulaşmaktadır. HOCl sulu çözelti içerisinde, H+ ve OClˉolarak ayrışır ve proteinleri denatüre eder. HOCl; kloraminler ve azotlu radikaller oluşturarak çift sarmallı DNA’ları parçalayarak virüsleri zararsız hale getirmektedir. HOCl, Covid-19 dâhil geniş bir tayfta virüslerin yok edilmesinde kullanım alanı bulan zayıf ama etkili bir asittir. Yapılan çalışmalar ışığında HOCl, gelecekte özellikle medikal sektöründe olmak üzere daha birçok alan da kullanım alanı bulacağı öngörülmektedir.

Anahtar Kelimeler

• Hipokloröz asit
• dezenfektan
• antimikrobiyal etki

Water, Salt, Hypochlorous Acid and Infection Protection

Abstract

Keywords

• Hypochlorous acid
• Disinfectant
• Antimicrobial effect

Kaynakça

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