Research Article

Persistence of Gastric Atrophy and Intestinal Metaplasia Six Months After H. pylori Treatment: A Retrospective Cohort Study

Volume: 4 Number: 3 October 23, 2026

Persistence of Gastric Atrophy and Intestinal Metaplasia Six Months After H. pylori Treatment: A Retrospective Cohort Study

Abstract

Objective: To assess the persistence and regression of gastric atrophy and intestinal metaplasia (IM) approximately six months after Helicobacter pylori treatment in patients undergoing repeat gastric biopsy.

Methods: This single-center retrospective cohort included 70 patients with biopsy-confirmed H. pylori infection who received 14-day quadruple therapy and underwent follow-up endoscopy with biopsy approximately six months later. Histological findings were compared with baseline findings.

Results: H. pylori was not detected on follow-up histology in 64/70 patients (91.4%). Among patients with baseline lesions, gastric atrophy persisted in 9/13 (69.2%) and IM in 19/21 (90.5%). No new atrophy (0/57) or IM (0/49) was identified among patients without the corresponding baseline lesion.

Conclusion: Gastric atrophy and IM remained detectable in most patients with these baseline lesions at six months. Longer follow-up is required to assess regression and treatment effects.

Keywords

Helicobacter pylori, Gastritis, Atrophic, Metaplasia, Treatment Outcome

Supporting Institution

No supporting instution.

Ethical Statement

This study was approved by the institutional ethics committee of Üsküdar University (approval No. 03; 27 March 2026). Informed consent was waived due to the retrospective study design, as permitted by the committee.

Thanks

None.

References

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APA
Açık, H., & Gökçe, K. (2026). Persistence of Gastric Atrophy and Intestinal Metaplasia Six Months After H. pylori Treatment: A Retrospective Cohort Study. Journal of Bursa Faculty of Medicine, 4(3), 58-62. https://doi.org/10.61678/bursamed.2058064
AMA
1.Açık H, Gökçe K. Persistence of Gastric Atrophy and Intestinal Metaplasia Six Months After H. pylori Treatment: A Retrospective Cohort Study. J Bursa Med. 2026;4(3):58-62. doi:10.61678/bursamed.2058064
Chicago
Açık, Hasan, and Kağan Gökçe. 2026. “Persistence of Gastric Atrophy and Intestinal Metaplasia Six Months After H. Pylori Treatment: A Retrospective Cohort Study”. Journal of Bursa Faculty of Medicine 4 (3): 58-62. https://doi.org/10.61678/bursamed.2058064.
EndNote
Açık H, Gökçe K (October 1, 2026) Persistence of Gastric Atrophy and Intestinal Metaplasia Six Months After H. pylori Treatment: A Retrospective Cohort Study. Journal of Bursa Faculty of Medicine 4 3 58–62.
IEEE
[1]H. Açık and K. Gökçe, “Persistence of Gastric Atrophy and Intestinal Metaplasia Six Months After H. pylori Treatment: A Retrospective Cohort Study”, J Bursa Med, vol. 4, no. 3, pp. 58–62, Oct. 2026, doi: 10.61678/bursamed.2058064.
ISNAD
Açık, Hasan - Gökçe, Kağan. “Persistence of Gastric Atrophy and Intestinal Metaplasia Six Months After H. Pylori Treatment: A Retrospective Cohort Study”. Journal of Bursa Faculty of Medicine 4/3 (October 1, 2026): 58-62. https://doi.org/10.61678/bursamed.2058064.
JAMA
1.Açık H, Gökçe K. Persistence of Gastric Atrophy and Intestinal Metaplasia Six Months After H. pylori Treatment: A Retrospective Cohort Study. J Bursa Med. 2026;4:58–62.
MLA
Açık, Hasan, and Kağan Gökçe. “Persistence of Gastric Atrophy and Intestinal Metaplasia Six Months After H. Pylori Treatment: A Retrospective Cohort Study”. Journal of Bursa Faculty of Medicine, vol. 4, no. 3, Oct. 2026, pp. 58-62, doi:10.61678/bursamed.2058064.
Vancouver
1.Hasan Açık, Kağan Gökçe. Persistence of Gastric Atrophy and Intestinal Metaplasia Six Months After H. pylori Treatment: A Retrospective Cohort Study. J Bursa Med. 2026 Oct. 1;4(3):58-62. doi:10.61678/bursamed.2058064