In this work, we investigated, through a short-term genotoxicity experiment,
the umu-test, the mutagenic activities of a group of phenolic Schiff bases, namely Material
A 2-(N-phenyliminomethyl)-phenol, Material B 2-(N-p-bromophenyliminomethyl)-
phenol, Material C 2-(N-p-methylphenyliminomethyl)-phenol and Material D 2-(N-panilinephenyl
iminomethyl)-phenol, the substances which we synthesized, in the chemistry
laboratories of our university, to form the raw materials of medicines. The umu-test
method is a colorimetric bacterial test system and has been developed on the basis of SOS
response induced by DNA damage. Materials A, B, C and D and the experimental materials
prepared in 5 different dose levels by dissolving these materials in DMSO have not
increased the galactosidase enzyme activity. When calculated with respect to the enzyme
unit calculation formula, results seemed to be not larger than the unit value of the positive
mutagenic material 4NQO. Results have also been evaluated statistically.
Konular | Mühendislik |
---|---|
Bölüm | Makaleler |
Yazarlar | |
Yayımlanma Tarihi | 1 Nisan 2010 |
Yayımlandığı Sayı | Yıl 2010 Cilt: 7 Sayı: 2 |