Prolonged Biomolecule Release from Titanium Surfaces via Titania Nanotube Arrays

Yıl 2022, , 1 - 7, 25.03.2022

Cem Bayram

https://doi.org/10.18466/cbayarfbe.972316

Öz

Surface modifications containing active biomolecules in order to minimize the failure of titanium implants used in hard tissue repair is one of the most frequently studied subjects in recent years. In the last decade, it has been investigated that nanoscale tubular spaces on the titanium surface can be used as a local drug release reservoir so that the molecule can be loaded into the implant structure without the need for any chemical binder or polymeric coating. It is possible to obtain one-dimensional structures that can be grown by electrochemical anodic oxidation by controlling the diameters of less than 100 nanometers on titanium metal surfaces. The major disadvantage of biomolecules released from titania nanotube structures to the environment is the hard control of release kinetics and more than half of the loading amount releases in the first few hours of interaction with the biological fluid. Although the studies on controlling the kinetics have been tried to overcome by covering the nanotube arrays with barriers such as polymer structures, the risk of delamination of the polymers from the surface during implantation brings additional problems. In this manuscript, vancomycin and bovine serum albumin were loaded into titania nanotubes formed by anodic oxidation technique on titanium metal plates and the tube ends has been narrowed by gold sputtering technique. With this narrowing at the tube-ends, the length of the release time and the change in diameter according to the hydrodynamic diameter of the released biomolecule were investigated. It is seen that the increased gold sputtering time prolongs the release rate of biomolecules and offers a promising approach for sustained local drug releasing implants.

Anahtar Kelimeler

titanium, sustained release, drug loading, implant, anodic oxidation, nanotube

Proje Numarası

FHD-6700

Kaynakça

• Dong, H, Liu, H, Zhou, N, Li, Q, Yang, G, Chen, L, Mou, Y. 2020. Surface Modified Techniques and Emerging Functional Coating of Dental Implants. Coatings, 10(11), 1012.
• Palka, K, Pokrowiecki, R. 2018. Porous Titanium Implants: A Review. Advabced Engineering Materials. 20,1700648.
• Nicholson, JW. 2020. Titanium Alloys for Dental Implants: A Review. Prosthesis, 2(2), 100-116.
• Draghi, L, Preda, V, Moscatelli, M, Santin, M, Chiesa, R. 2020. Gentamicin-Loaded TiO2 Nanotubes as Improved Antimicrobial Surfaces for Orthopedic Implants. Frontiers in Materials, 7:233.
• Ion, R, Necula MG, Mazare A, Mitran V, Neacsu P, Schmuki P, Cimpean A, 2020. Drug Delivery Systems Based on Titania Nanotubes and Active Agents for Enhanced Osseointegration of Bone Implants. Current Medicinal Chemistry, 27(6), 854-902.
• Losic, D. 2021. Advancing of titanium medical implants by surface engineering: recent progress and challenges, Expert Opinion on Drug Delivery, 10.1080/17425247.2021.1928071.
• Zhao, L, Chu, PK, Zhang, Y, Wu, Z. 2009. Antibacterial coatings on titanium implants, Journal of Biomedical Material Research B Applied Biomaterials, 91, 470–480.
• Turanli, AE, Sokullu, E, Nikolayev, A, Dagci, T, Öztarhan, A. 2016. Dental İmplant Materyallerin İyon İmplantasyon Yöntemiyle Modifikasyonlarının in vitro Hücre Tutunmasına Etkisi, CBÜ Fen Bil. Dergi, Cilt 12, Sayı 2, 243-251.
• Sarkar, N, Bose, S. 2020. Controlled Delivery of Curcumin and Vitamin K2 from Hydroxyapatite-Coated Titanium Implant for Enhanced in Vitro Chemoprevention, Osteogenesis, and in Vivo Osseointegration. ACS Appl. Mater. Inter.,12(12),13644-13656.
• Zilberman, M, Elsner, JJ. 2008. Antibiotic-eluting medical devices for various applications. Journal of Controlled Release,130, 202–215.
• Macak, JM, Tsuchiya, H, Schmuki, P. 2005. High-Aspect Ratio TiO2 Nanotubes by Anodization Titanium, Angewandte Chemistry International Edition, 44, 2100-2102.
• Popat, KC, Eltgroth, M, LaTempa, TJ, Grimes, CA, Desai, TA. 2007. Decreased Staphylococcus epidermis adhesion and increased osteoblast functionality on antibiotic-loaded titania nanotubes, Biomaterials, 28, 4880-4888.
• Yao, C. Webster, TJ. 2009. Prolonged Antibiotic Delivery from Anodized Nanotubular Titanium Using a Co-precipitation Drug Loading Method, Journal of Biomedical Material Research B Applied Biomaterials 91B: 587–595.
• Peng, L, Mendelsohn, AD, LaTempa, TJ, Yoriya, S, Grimes, CA, Desai, TA. 2009 Long-Term Small Molecule and Protein Elution from TiO2 Nanotubes, Nano Letters, 9, 1932-1936.
• Ma, M, Kazemzadeh-Narbat, M, Hui, Y, Lu, S, Ding, C, Chen, DDY, Hancock, REW, Wang, R. 2012. Local delivery of antimicrobial peptides using self-organized TiO2 nanotube arrays for peri-implant infections, Journal of Biomedical Material Research 100A: 278–285.
• Sinn Aw, M, Kurian, M, Losic, D. 2014. Non-eroding drug-releasing implants with ordered nanoporous and nanotubular structures: Concepts for controlling drug release, Biomaterials Science, 9, 9243-9257.
• Gulati, K, Kant, K, Findlay D, Losic, D. 2015. et al., Periodically tailored titania nanotubes for enhanced drug loading and releasing performances. J Mater Chem B, 2015. 3: p. 2553-2559.
• Gulati, K, Ramakrishnan, S, Aw, MS, Atkins, GJ, Findlay, DM, Losic, D. 2012. Biocompatible polymer coating of titania nanotube arrays for improved drug elution and osteoblast adhesion, Acta Biomaterialia, 8, 449-456.
• Caliskan, N, Bayram, C, Erdal, E, Karahaliloglu, Z, Denkbas, EB. 2014. Titania nanotubes with adjustable dimensions for drug reservoir sites and enhanced cell adhesion. Mater Sci Eng C, 2014. 35: p. 100-105.
• Chopra, D, Gulati, K, Ivanovski, S. 2021. Understanding and optimizing the antibacterial functions of anodized nano-engineered titanium implants. Acta Biomaterialia, 2021. 127:80-101.