Cytomegalovirus Retinitis in a Patient with Large Cell Diffuse Non-Hodgkin’s Lymphoma

Abstract

Non-Hodgkin lymphoma is a reticuloendothelial malignancy and usually characterized by malignant proliferation of B cell lymphocytes. Immunosuppressive drugs used in reticuloendothelial malignancy treatments may cause opportunistic infections. Cytomegalovirus (CMV) can also cause such an infection. A patient with nonhodgkin lymphoma who had decreased vision due to CMV retinitis is presented. Cytomegalovirus (CMV) retinitis is rarely seen in lymphoma patients and can be confused clinically with intraocular lymphomas. A 27-year-old female patient who received chemotherapy for a non-Hodgkin lymphoma (NHL) presented to our clinic with loss of visual field and decreased vision in both eyes. Fundus examination revealed retinal hemorrhages, exudative deposits and perivascular retinitis in both eyes. As it is thought to have CMV retinitis based on the clinical characteristics of the patient, we also examined serum CMV IgG, IgM and CMV DNA levels to support the diagnosis. Immediately, intravenous ganciclovir treatment was started followed by orally vanganciclovir.

Keywords

• Non-hodgkin Lymphoma ; cytomegalovirus retinitis
• ganciclovir
• valganciclovir

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