The Uric Acid / Albumin Ratio in Acute Kidney Injury Developing in Intensive Care Unit: A Case-Control Study

Abstract

Background and Aim: Various scoring systems and markers are used in intensive care practice, and molecules which can predict mortality and change the course of treatment continue to be researched. We aimed to investigate whether uric acid, albumin, uric acid/albumin ratio and uric acid/creatinine ratio were associated with mortality in intensive care cases. Materials and Methods: Our study was designed retrospectively and involved 600 cases. The uric acid and albumin values of the cases were recorded at the time of admission were recorded, and the uric acid/albumin ratio and uric acid/creatine ratio were calculated. APACHE-II scores and SOFA scores of all the patients at the time of admission were recorded. Results: Uric acid, uric/albumin ratio, uric acid/creatinine ratios of Groups AKI and Non-AKI were statistically significant(p<0.001, p<0.001, p<0.001, respectively).When exitus and discharged cases were compared, albumin and uric acid/albumin ratios were statistically significant (p<0.050, p<0.050,in order). The cut-off value for albumin was found as 2.75. Mortality increases at the values below 2.75. A meaningful difference was detected between the distributions of albumin cut-off value according to the last condition of the patients (p=0.038). We discovered a notable correlation between albumin ,uric acid/creatinine ratio , APACHE-II , SOFA scores (p values p=0.045; p=0.012; p=0.018; p=0.020,seriatim). Conclusion: Uric acid/albumin ratio may be a useful biomarker in predicting prognosis in cases of acute kidney injury. We believe that our study will shed light on future studies on the uric acid/albumin ratio in larger populations and different patient groups.

Keywords

• Intensive care
• mortality
• uric acid
• uric acid albumin ratio
• uric acid creatinine ratio

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