A Cause of Bicytopenia in Infancy: CMV

Abstract

Bicytopenia is frequently observed in the pediatric population as a result of transient bone marrow suppression, which may occur following vaccination or as a consequence of viral infections, including influenza, Epstein-Barr virus (EBV), and cytomegalovirus (CMV). Symptoms of CMV infection, one of these agents, vary according to age and host immune competence. Although it is usually asymptomatic in healthy children, it can cause various infectious clinical presentations. In immunocompromised patients, it may cause pneumonia, retinitis, hepatitis, fever, thrombocytopenia and leukopenia. Here, we present a 4-month-old girl who was investigated for bicytopenia and subsequently diagnosed with CMV infection.

Keywords

• cytomegalovirus
• CMV
• bicytopenia
• neutropenia
• thrombocytopenia

Project Number

1595997

Süt Çocukluğu Döneminde Bir Bisitopeni Nedeni: CMV

Abstract

Bisitopeni pediatrik popülasyonda sıklıkla İnfluenza, Ebstein-Barr virüs (EBV), sitomegalovirüs (CMV) gibi viral enfeksiyonların ardından ya da aşı uygulamaları sonrasında kemik iliğinin geçici baskılanması ile karşımıza çıkar. Bu etkenlerden olan CMV enfeksiyonunun belirtileri ise yaşa ve konak immün yeterliliğine göre değişir. Sağlıklı çocuklarda genellikle asemptomatik görülmekle birlikte çeşitli enfeksiyöz klinik tablolara sebep olabilir. İmmun sistemi baskılanmış kişilerde pnömoni, retinit, hepatit, ateş, trombositopeni ve lökopeni gibi tablolara yol açabilir. Burada bisitopeni sebebiyle araştırılan ve CMV enfeksiyonu saptanan 4 aylık bir kız hastayı sunduk.

Keywords

• Sitomegalovirüs
• CMV
• trombositopeni
• nötropeni
• bisitopeni

Project Number

1595997

References

1. Plosa EJ, Esbenshade JC, Fuller MP, Weitkamp JH. Cytomegalovirus infection. Pediatr Rev. 2012;33(4):156-163. doi:10.1542/pir.33-4-156
2. Kimberlin D.W.(Editor) Red Book Atlas of Pediatric Infectious Diseases. American Academy of Pediatrics; 2018-2021.
3. Vijayakrishnan, G., Thambi, R., & Sankar, S. A. (2020). year study of clinico hematological profile of bicytopenia and pancytopenia in paediatric patients attending a tertiary hospital in South India. IJPO, 7, 207-11.
4. Singh S, Roach V, Katoch P. Clinico Haematological Profile in Paediatric Patients with Bicytopenia and Pancytopenia in a Tertiary Care Referral Centre of North India. Journal of Advances in Medicine and Medical Research, 2021; 33(18): 57-63.
5. Kumar G, Verma S, Chavan S, Gupta A, Avuthu OPR, Mane S, Pathak N. Study of Clinicoetiological Spectrum of Bicytopenia and Pancytopenia in Hospitalized Children. Cureus. 2024; 16(8); e66255.
6. Yalaki Z, İçöz S, Arikan FI, Alioglu B, Dallar YB. Our Experience with Bicytopenia in Patients Treated at the Ankara Hospital Pediatric Clinic. J Pediatr Inf. 2014; 8(1): 23.
7. Celkan T, Koç BŞ. Approach to the patient with neutropenia in childhood. Turk Pediatri Ars. 2015;50(3):136-144. Published 2015 Sep 1. doi:10.5152/TurkPediatriArs.2015.2295
8. Tokgöz H,Çalışkan Ü. Hematologic manifestations of infectious diseases in children. Selçuk Tıp Dergisi. 2017; 33(3): 63-66.