GCF LEVELS OF sRAGE AND MCP-1 IN TYPE-2 DIABETIC PATIENTS WITH PERIODONTITIS: A PRELIMINARY REPORT

Yağmur Deniz Yıldırım; Esra Ercan; Güliz Nigar Güncü; Erdem Karabulut; Ayşe Ezel Berker

GCF LEVELS OF sRAGE AND MCP-1 IN TYPE-2 DIABETIC PATIENTS WITH PERIODONTITIS: A PRELIMINARY REPORT

Abstract

Background and Aim: Diabetes mellitus-related chronic complications can affect multiple organs, including the macrovascular and microvascular systems, as well as the periodontium. Advanced glycation end products (AGE), its receptor (RAGE) and soluble receptor (sRAGE) interaction is critically involved in the pathobiology of both diseases. Monocyte chemoattractant protein-1 (MCP-1) is an essential chemokine responsible for the recruitment of monocytes to inflammatory lesions in the vasculature, an initial step of atherosclerosis. This study aimed to compare the levels of MCP-1 and sRAGE in the gingival crevicular fluid (GCF) of periodontitis patients with type 2 diabetes and those without, hypothesizing that these levels may vary based on diabetic status. Materials and Methods: Nine patients with periodontitis and diabetes (DP), 12 periodontitis (P) patients without diabetes, 12 systemically and periodontally healthy subjects (HC) were enrolled in this case-control study. Clinical periodontal parameters and HbA1c values were evaluated. Gingival crevicular fluid samples were analysed for sRAGE and MCP-1 by an enzyme-linked immunosorbent assay. The significance of differences were assessed with Kruskall-Wallis test. Pairwise comparisons were made with Dunn test. Results: sRAGE and MCP-1 levels were significantly higher in periodontitis group than healthy controls (p<0.05). There was no difference between DP and P groups (p>0.05). Positive correlation was detected between sRAGE and MCP-1 levels in disease groups (p=0.000, r=0.976 for DP group; p=0.000, r=0.982 for P group respectively). Conclusion: MCP-1 and sRAGE may have a functional role in the diabetic-periodontal pathogenesis. Further studies must be carried out to understand the contribution of sRAGE and MCP-1 in periodontal inflammation with or without diabetes.

Keywords

References

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Details

Primary Language

English

Subjects

Periodontics

Journal Section

Research Article

Authors

Yağmur Deniz Yıldırım ^*
0000-0002-7012-379X
Türkiye

Esra Ercan
0000-0002-8696-4198
Türkiye

Güliz Nigar Güncü
0000-0001-8456-5583
Türkiye

Erdem Karabulut
0000-0002-7811-8215
Türkiye

Ayşe Ezel Berker
0000-0001-8990-5866
Türkiye

Publication Date

December 20, 2024

Submission Date

July 8, 2024

Acceptance Date

October 11, 2024

Published in Issue

Year 2024 Volume: 48 Number: 3

IZ

https://izlik.org/JA94AK93TC

Cite

RIS / Bibtex

APA

Yıldırım, Y. D., Ercan, E., Güncü, G. N., Karabulut, E., & Berker, A. E. (2024). GCF LEVELS OF sRAGE AND MCP-1 IN TYPE-2 DIABETIC PATIENTS WITH PERIODONTITIS: A PRELIMINARY REPORT. Clinical Dentistry and Research, 48(3), 133-139. https://izlik.org/JA94AK93TC

AMA

1.Yıldırım YD, Ercan E, Güncü GN, Karabulut E, Berker AE. GCF LEVELS OF sRAGE AND MCP-1 IN TYPE-2 DIABETIC PATIENTS WITH PERIODONTITIS: A PRELIMINARY REPORT. Clin Dent Res. 2024;48(3):133-139. https://izlik.org/JA94AK93TC

Chicago

Yıldırım, Yağmur Deniz, Esra Ercan, Güliz Nigar Güncü, Erdem Karabulut, and Ayşe Ezel Berker. 2024. “GCF LEVELS OF SRAGE AND MCP-1 IN TYPE-2 DIABETIC PATIENTS WITH PERIODONTITIS: A PRELIMINARY REPORT”. Clinical Dentistry and Research 48 (3): 133-39. https://izlik.org/JA94AK93TC.

EndNote

Yıldırım YD, Ercan E, Güncü GN, Karabulut E, Berker AE (December 1, 2024) GCF LEVELS OF sRAGE AND MCP-1 IN TYPE-2 DIABETIC PATIENTS WITH PERIODONTITIS: A PRELIMINARY REPORT. Clinical Dentistry and Research 48 3 133–139.

IEEE

[1]Y. D. Yıldırım, E. Ercan, G. N. Güncü, E. Karabulut, and A. E. Berker, “GCF LEVELS OF sRAGE AND MCP-1 IN TYPE-2 DIABETIC PATIENTS WITH PERIODONTITIS: A PRELIMINARY REPORT”, Clin Dent Res, vol. 48, no. 3, pp. 133–139, Dec. 2024, [Online]. Available: https://izlik.org/JA94AK93TC

ISNAD

Yıldırım, Yağmur Deniz - Ercan, Esra - Güncü, Güliz Nigar - Karabulut, Erdem - Berker, Ayşe Ezel. “GCF LEVELS OF SRAGE AND MCP-1 IN TYPE-2 DIABETIC PATIENTS WITH PERIODONTITIS: A PRELIMINARY REPORT”. Clinical Dentistry and Research 48/3 (December 1, 2024): 133-139. https://izlik.org/JA94AK93TC.

JAMA

1.Yıldırım YD, Ercan E, Güncü GN, Karabulut E, Berker AE. GCF LEVELS OF sRAGE AND MCP-1 IN TYPE-2 DIABETIC PATIENTS WITH PERIODONTITIS: A PRELIMINARY REPORT. Clin Dent Res. 2024;48:133–139.

MLA

Yıldırım, Yağmur Deniz, et al. “GCF LEVELS OF SRAGE AND MCP-1 IN TYPE-2 DIABETIC PATIENTS WITH PERIODONTITIS: A PRELIMINARY REPORT”. Clinical Dentistry and Research, vol. 48, no. 3, Dec. 2024, pp. 133-9, https://izlik.org/JA94AK93TC.

Vancouver

1.Yağmur Deniz Yıldırım, Esra Ercan, Güliz Nigar Güncü, Erdem Karabulut, Ayşe Ezel Berker. GCF LEVELS OF sRAGE AND MCP-1 IN TYPE-2 DIABETIC PATIENTS WITH PERIODONTITIS: A PRELIMINARY REPORT. Clin Dent Res [Internet]. 2024 Dec. 1;48(3):133-9. Available from: https://izlik.org/JA94AK93TC