Inflammation in depression: the role of cytokines

Yıl 2012, Cilt: 2 Sayı: 3, 103 - 107, 30.01.2014

Salih Gümrü Feyza Arıcıoğlu

Öz

Recent studies support the concept that inflammatory mechanisms play a crucial role in the pathomechanisms of major depression. Major depression shares similarities with ‘sickness behavior’, a normal response to inflammatory cytokines. Elevations in proinflammatory cytokines and other inflammation-related proteins in major depression were found in plasma and cerebrospinal fluid (CSF). Clinical progress of the disease may also be predicted by the changes in proinflammatory cytokine levels. Antidepressant treatment can lead to a normalization of elevated cytokine levels in major depression. The new hypothesis of depression provided some new opportunities in treatment of depression.

Key words: Cytokine, inflammation, depression, antidepressant

Anahtar Kelimeler

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Depresyonda inflamasyon: sitokinlerin rolü

Öz

Son yıllarda yapılan çalışmalar majör depresyonun patolojisinde inflamatuvar mekanizmaların önemli rol oynadığını göstermektedir. Majör depresyonda, inflamatuvar sitokinlere verilen yanıt olan “hastalık davranışı”na benzer belirtiler görülmektedir. Depresif hastaların plazma ve beyin omurilik sıvılarında proinflamatuvar sitokinler ve inflamasyonla bağlantılı proteinlerin miktarında artış gözlenir. Hastalığın prognozu da sitokin değerlerindeki değişmelerle paralellik göstermektedir. Antidepresan tedavi ile sitokin seviyeleri normale çevrilebilmektedir. Depresyonun bu yeni hipotezi, tedavide de yenilikleri gündeme getirmiştir.

Anahtar Kelimeler : Sitokin, inflamasyon, depresyon, antidepresan

Anahtar Kelimeler

Sitokin, inflamasyon, depresyon, antidepresan

Kaynakça

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