Does Patient-Controlled Infraclavicular Perineural Dexmedetomidine Increase the Duration of Postoperative Analgesia?

Year 2018, Volume: 8 Issue: 3, 154 - 159, 28.09.2018

İlke Kupeli , Ufuk Kuyrukluyıldız Sara Taş Zehra Bedir Ayşin Selcan

https://doi.org/10.5152/clinexphealthsci.2017.413

Abstract

Objective: Peripheral nerve blocks are now used widely for postoperative analgesia

and peripheral nerve catheters are widely utilized. Objective of this study was to

investigate effect of perineural infusion of dexmedetomidine on the duration of

postoperative analgesia retrospectively.

Material & Methods: A total of 60 patients aged between 18 and 65 years were

included in the study. Group 1 received infraclavicular patient-controlled perineural

bupivacaine (0.1 %). Group 2 received infraclavicular patient-controlled perineural

bupivacaine (0.1 %) + dexmedetomidine (200 mic/100 cc). Blood pressure, pulse,

peripheral oxygen saturation modified ramsay sedation scale, visual pain scores, total

amount of analgesics were recorded at the 0, 30, 60, 90 minutes and 2, 4, 6, 8, 12,

24 hours.

Results: Systolic blood pressure was higher in Group 1 at the hour 6 (p: 0.007).

Whereas, diastolic blood pressure was higher in Group 1 at the hours 4 and 6 (p:

0.000, p: 0.003). Heart rate was found to be higher in Group 2 at the hours 8, 12 and

24 (p: 0.004, p: 0.002, p: 0.002). Patients in Group 1 were found to significantly feel

pain and need analgesics at the hours 4 and 6 (p: 0.002, p< 0.05). The mean number

of patient requests for analgesia was 5.8±1.4 times in Group 1 and 2.2±0.4 in Group

2 (p<0,05). None of the patients developed sedation/neurological deficits.

Conclusion: Perineural infusion of dexmedetomidine combined with bupivacaine

was found to increase the duration of postoperative analgesia, reduce 24-hour need

for analgesia and have not any adverse efect at low doses.

Keywords

Patient-Controlled Analgesia; Perineural Dexmedetomidine infusion; Duration of Postoperative Analgesia

References

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