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Squamous Cell Carcinoma of The Gingiva: A Case Report and Literature Review

Yıl 2015, Cilt: 5 Sayı: 4, 290 - 295, 29.12.2015
https://doi.org/10.5455/musbed.20150831012106

Öz

Squamous cell carcinoma (SCC) is the most frequent epithelial malignancy of the oral cavity which is characterized by variable clinical manifestations. It arises from dysplastic oral squamous epithelium. By considering the pathogenesis of SCC, the smooth and intact surface for this lesion is not usual. A 52-year-old female patient was refered to Marmara University, Faculty of Dentistry, Oral Diagnosis Clinic with a chief complaint of generalized swelling of the gingiva. There was neither significant medical and family history nor any history of medication. No bleeding was reported and submandibular lymphadenopathy (LAD) was noted. Buccal and a palatinal mucosal tissue of left maxillary first molar had a verrucous appearance. In addition to clinical examination, a smear biopsy and then incisional biopsy was performed and histopathological examination revealed the lesion had a malign characterization with a diagnosis of ‘squamous epithelium carcinoma’. Consequently, the patient was referred to Ear, Nose and Throat (ENT) department where the lesion was treated by surgery

Kaynakça

  • 1. Barnes L, Eveson JW., Reichart P , Sidransky D eds. Pathology and genetics of head and neck tumours. World Health Organisation Classification of Tumours. Volume 9. Lyon: IARC Press; 2005. p. 118-211.
  • 2. Barasch A, Gofa A, Krutchkoff DJ, Eisenberg E. Squamous cell carcinoma of the gingiva. A case series analysis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod.1995; 80: 183-187. 3. Myers JN, Elkins T, Roberts D. Squamous cell carcinoma of the tongue in young adults: Increasing incidence and factors that predict treatment outcomes. Otolaryng Head Neck. 2000; 122: 44-51.
  • 4. Annertz K, Anderson H, Biorklund A. Incidence and survival of squamous cell carcinoma of the tongue in Scandinavia, with special reference to young adults. Int J Cancer. 2002; 101: 95-99.
  • 5. Torabinejad M, Rick GM. Squamous cell carcinoma of the gingiva. J Am Dent Assoc. 1980; 100(6): 870-872.
  • 6. Yoon TY, Bhattacharyya I, Katz J, Towle HJ, Islam MN. Squamous cell carcinoma of the gingiva presenting as localized periodontal disease. Quintessence Int. 2007; 38(2): 97-102. 7. Kramer D, Durham JS, Jackson S, Brookes J. Management of the neck in NO Squamous cell carcinoma of the oral cavity. J Otolaryngol. 2001; 30: 283-288.
  • 8. Misra S, Chaturvedi A, Misra NC. Management of gingivobuccal complex cancer. Ann R Coll Surg Engl. 2008; 90: 546-553.
  • 9. Cabral LA, Carvalho LF, Salgado JA, Brandão AA, Almeida JD. Gingival squamous cell carcinoma: a case report. J Oral Maxillofac Res. 2010; 1(3): e6.
  • 10. Regezi JA, Sciubba JJ. Oral pathology: Clinical pathologic correlations. 3rd ed. Philadelphia: WB Saunders; 1999.p. 69-79.
  • 11. Tajima Y, Shionoya N, Fujita K, Utsumi N. Epidermoid carcinoma originating from the gingival sulcus. Eur J Cancer B Oral Oncol. 1993; 29: 319-321.
  • 12. Rivera C, González-Arriagada WA, Loyola-Brambilla M, de Almeida OP, Coletta RD, Venegas B. Clinicopathological and immunohistochemical evaluation of oral and oropharyngeal squamous cell carcinoma in Chilean population. Int J Clin Exp Pathol. 2014; 7(9): 5968-5977.
  • 13. Matthews JB, Scully C, Jovanovic A, Waal VD, Yeudall WA, Prime SS. Relationship of tobacco/alcohol use to p53 expression in patients with lingual squamous cell carcinomas. Eur J Cancer. 1993; 29: 285- 289.
  • 14. Neville BW, Damm DD, Allen CM, Bouquot JE. Oral & Maxillofacial Pathology. Philadelphia: WB Saunders; 1992. p. 295-304.
  • 15. Datta S, Chaturvedi P, Mishra A, Pawar P. A review of Indian literature for association of smokeless tobacco with malignant and premalignant diseases of head and neck region. Indian J Cancer. 2014; 51: 200-208.
  • 16. World Health Organization. WHO report on the global tobacco epidemic, 2011: Warning about the dangers of tobacco. Geneve: WHO, 2011. 17. Bandeira CM, Almeida AÁ, Gonçalves AJ. Genetic polymorphisms in the Cytochrome P450 family and squamous cell carcinoma of the oral cavity, pharynx and larynx. Rev Col Bras Cir. 2014; 41(5): 366-372.
  • 18. Shenoi R, Devrukhkar V, Chaudhuri, Sharma BK, Sapre SB, Chikhale A. Demographic and clinical profile of oral squamous cell carcinoma patients: A retrospective study. Indian J Cancer. 2012; 49: 21-26.
  • 19. Sieczka E, Datta R. Singh A, Loree T, Rigual N, Omer J, Hicks W. Cancer of the buccal mucosa: Are margins and T-stage accurate predictor of local control? Am J Otolaryngol. 2001; 22: 395-399.
  • 20. Attar E, Dey S, Hablas A, Seifeldin IA, Ramadan M, Rozek LS, Soliman AS. Head and neck cancer in a developing country: a population-based perspective across 8 years. Oral Oncol. 2010; 46(8): 591-596.
  • 21. Bagan J, Sarrion G, Jimenez Y. Oral Cancer: Clinical Features. Oral Oncol. 2010; 46(6): 414-417.
  • 22. Shah JP, Gil Z. Current Concepts in Management of Oral Cancer- Surgery. Oral Oncol. 2009; 45(4): 394-401.
  • 23. Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer. Oral Oncol. 2009; 45(45): 309-316.
  • 24. Oral cancer Incidence Statistics. Cancer Research UK; 2010. Available from: http://www.cancerresearchuk.org/.
  • 25. Friedlander PL, Schantz SP, Shaha AR, Yu G, Shah JP. Squamous cell carcinoma of the tongue in young patients: a matched-pair analysis. Head Neck. 1998; 20: 363-368.
  • 26. Llewellyn CD, Johnson NW, Warnakulasuriya KAAS. Risk factors for squamous cell carcinoma of the oral cavity in young people – a comprehensive literature review. Oral Oncol. 2001; 37: 401-418.
  • 27. Feller L, Lemmer J. Oral Squamous Cell Carcinoma: Epidemiology, Clinical Presentation and Treatment. Journal of Cancer Therapy. 2012; (3): 263-268. 28. La Vecchia C, Lucchini F, Negri E, Levi F. Trends in oral cancer mortality in Europe. Oral Oncol. 2004; 40(4): 433-439. 29. Ferreira Antunes JL, Toporcov TN, Biazevic MG, Boing AF, Scully C, Petti S. Joint and independent effects of alcohol drinking and tobacco smoking on oral cancer: a large case–control study. PLoS One. 2013; 8(7): e68132. 30. Hashibe M, Brennan P, Benhamou S, Castellsague X, Chen C, Curado MP, Dal Maso L, Daudt AW, Fabianova E, Fernandez L, Wünsch-Filho V, Franceschi S, Hayes RB, Herrero R, Koifman S, La Vecchia C, Lazarus P, Levi F, Mates D, Matos E, Menezes A, Muscat J, Eluf-Neto J, Olshan AF, Rudnai P, Schwartz SM, Smith E, Sturgis EM, Szeszenia-Dabrowska N, Talamini R, Wei Q, Winn DM, Zaridze D, Zatonski W, Zhang ZF, Berthiller J, Boffetta P. Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. J Natl Cancer Inst. 2007; 99(10): 777-789.
  • 31. Castellsague X, Quintana MJ, Martinez MC, Nieto A, Sanchez MJ, Juan A, Monner A, Carrera M, Agudo A, Quer M, Muñoz N, Herrero R, Franceschi S, Bosch FX. The role of type of tobacco and type of alcoholic beverage in oral carcinogenesis. Int J Cancer. 2004; 108(5): 741-749.
  • 32. Curado MP, Hashibe M. Recent changes in the epidemiology of head and neck cancer. Curr Opin Oncol. 2009; 21(3): 194-200.
  • 33. Wünsch-Filho V. The epidemiology of oral and pharynx cancer in Brazil. Oral Oncol. 2002; 38(8): 737-746. 34. Basu R, Mandal S, Ghosh A, Poddar TK. Role of tobacco in the development of head and neck squamous cell carcinoma in an eastern Indian population. Asian Pac J Cancer Prev. 2008; 9: 381 386.
  • 35. Martin HE. Cancer of the gums (gingivae). Am J Surg.1941; 54: 769- 806. 36. Shafer WG, Hine MK, Levy BM. A Textbook of Oral Pathology, 4th ed. Philadelphia: WB Saunders; 1983. p. 124-126.
  • 37. Joseph AR, James JS. Oral Pathology: Clinical Pathologic Correlations, 3rd ed. Philadelphia: WB Saunders; 1999. p.69-81. 38. Rikardsen OG, Bjerkli IH, Lars Uhlin-Hansen L, Hadler-Olsen E, Steigen SE. Clinicopathological characteristics of oral squamous cell carcinoma in Northern Norway: a retrospective study. BMC Oral Health. 2014; 14: 103.
  • 39. Bello IO, Soini Y, Salo T. Prognostic evaluation of oral tongue cancer: means, markers and perspectives (I). Oral Oncol. 2010; 46(9): 630-635.
  • 40. Neville BW, Day TA. Oral cancer and precancerous lesions. CA Cancer J Clin. 2002; 52(4): 195-215.
  • 41. Scully C, Bagan J. Oral squamous cell carcinoma overview. Oral Oncol. 2009; 45(4-5): 301-308.
  • 42. Tyagi N, Tyagi R. Squamous cell carcinoma (well differentiated):A case report J. Dent. Oral Hyg. 2013; 5(4): 31-34.
  • 43. Neville BW, Damm DD, Allen C, Bouquet J. Oral and Maxillofacial Pathology, 2nd ed. Elsevier; 2008. p.451-452.

Gingivanın Skuamöz Hücreli Karsinomu: Vaka Sunumu ve Literatür Taraması

Yıl 2015, Cilt: 5 Sayı: 4, 290 - 295, 29.12.2015
https://doi.org/10.5455/musbed.20150831012106

Öz

Skuamöz hücreli karsinom (SCC) oral kavitede
en sık görülen ve farklı klinik belirtiler ile karakterize malign epitelyal bir
neoplazmdır. SCC displastik oral skuamöz epitelinden doğmaktadır. SCC
patogenezi göz önüne alınırsa oluşan lezyon için pürüzsüz ve sağlam bir yüzey
olağan değildir. 52 yaşında kadın hasta dişetinde büyüme şikayeti ile Marmara Üniversitesi
Diş Hekimliği Fakültesi Oral Diagnoz Kliniğine yönlendirl­miştir. Hastanın tıbbi
anamnezinde herhangi bir sistemik hastalık olma­dığı öğrenilmiştir. Ayrıca
lenfadenopati tespit edilmemiştir. Sol maksiller birinci molar bölgede bukkal
ve palatinal mukozada verrüköz bir görün­tü oluşturan lezyon ve dokuda
hipertrofi izlenmiştir. Klinik muayeneye ek olarak ilgili bölgeden önce smear
biyopsi ve sonrasında ise insizyonel biyopsi alınmıştır. Histopatolojik
inceleme sonucunda lezyonun ‘skua­möz hücreli karsinom’ tanısı ile malign
karakterde olduğu saptanmıştır. Sonuç olarak hasta lezyonun cerrahi operasyon
ile elimine edilmesi için Kulak, Burun, Boğaz (KBB) departmanına yönlendirilmiştir.

Kaynakça

  • 1. Barnes L, Eveson JW., Reichart P , Sidransky D eds. Pathology and genetics of head and neck tumours. World Health Organisation Classification of Tumours. Volume 9. Lyon: IARC Press; 2005. p. 118-211.
  • 2. Barasch A, Gofa A, Krutchkoff DJ, Eisenberg E. Squamous cell carcinoma of the gingiva. A case series analysis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod.1995; 80: 183-187. 3. Myers JN, Elkins T, Roberts D. Squamous cell carcinoma of the tongue in young adults: Increasing incidence and factors that predict treatment outcomes. Otolaryng Head Neck. 2000; 122: 44-51.
  • 4. Annertz K, Anderson H, Biorklund A. Incidence and survival of squamous cell carcinoma of the tongue in Scandinavia, with special reference to young adults. Int J Cancer. 2002; 101: 95-99.
  • 5. Torabinejad M, Rick GM. Squamous cell carcinoma of the gingiva. J Am Dent Assoc. 1980; 100(6): 870-872.
  • 6. Yoon TY, Bhattacharyya I, Katz J, Towle HJ, Islam MN. Squamous cell carcinoma of the gingiva presenting as localized periodontal disease. Quintessence Int. 2007; 38(2): 97-102. 7. Kramer D, Durham JS, Jackson S, Brookes J. Management of the neck in NO Squamous cell carcinoma of the oral cavity. J Otolaryngol. 2001; 30: 283-288.
  • 8. Misra S, Chaturvedi A, Misra NC. Management of gingivobuccal complex cancer. Ann R Coll Surg Engl. 2008; 90: 546-553.
  • 9. Cabral LA, Carvalho LF, Salgado JA, Brandão AA, Almeida JD. Gingival squamous cell carcinoma: a case report. J Oral Maxillofac Res. 2010; 1(3): e6.
  • 10. Regezi JA, Sciubba JJ. Oral pathology: Clinical pathologic correlations. 3rd ed. Philadelphia: WB Saunders; 1999.p. 69-79.
  • 11. Tajima Y, Shionoya N, Fujita K, Utsumi N. Epidermoid carcinoma originating from the gingival sulcus. Eur J Cancer B Oral Oncol. 1993; 29: 319-321.
  • 12. Rivera C, González-Arriagada WA, Loyola-Brambilla M, de Almeida OP, Coletta RD, Venegas B. Clinicopathological and immunohistochemical evaluation of oral and oropharyngeal squamous cell carcinoma in Chilean population. Int J Clin Exp Pathol. 2014; 7(9): 5968-5977.
  • 13. Matthews JB, Scully C, Jovanovic A, Waal VD, Yeudall WA, Prime SS. Relationship of tobacco/alcohol use to p53 expression in patients with lingual squamous cell carcinomas. Eur J Cancer. 1993; 29: 285- 289.
  • 14. Neville BW, Damm DD, Allen CM, Bouquot JE. Oral & Maxillofacial Pathology. Philadelphia: WB Saunders; 1992. p. 295-304.
  • 15. Datta S, Chaturvedi P, Mishra A, Pawar P. A review of Indian literature for association of smokeless tobacco with malignant and premalignant diseases of head and neck region. Indian J Cancer. 2014; 51: 200-208.
  • 16. World Health Organization. WHO report on the global tobacco epidemic, 2011: Warning about the dangers of tobacco. Geneve: WHO, 2011. 17. Bandeira CM, Almeida AÁ, Gonçalves AJ. Genetic polymorphisms in the Cytochrome P450 family and squamous cell carcinoma of the oral cavity, pharynx and larynx. Rev Col Bras Cir. 2014; 41(5): 366-372.
  • 18. Shenoi R, Devrukhkar V, Chaudhuri, Sharma BK, Sapre SB, Chikhale A. Demographic and clinical profile of oral squamous cell carcinoma patients: A retrospective study. Indian J Cancer. 2012; 49: 21-26.
  • 19. Sieczka E, Datta R. Singh A, Loree T, Rigual N, Omer J, Hicks W. Cancer of the buccal mucosa: Are margins and T-stage accurate predictor of local control? Am J Otolaryngol. 2001; 22: 395-399.
  • 20. Attar E, Dey S, Hablas A, Seifeldin IA, Ramadan M, Rozek LS, Soliman AS. Head and neck cancer in a developing country: a population-based perspective across 8 years. Oral Oncol. 2010; 46(8): 591-596.
  • 21. Bagan J, Sarrion G, Jimenez Y. Oral Cancer: Clinical Features. Oral Oncol. 2010; 46(6): 414-417.
  • 22. Shah JP, Gil Z. Current Concepts in Management of Oral Cancer- Surgery. Oral Oncol. 2009; 45(4): 394-401.
  • 23. Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer. Oral Oncol. 2009; 45(45): 309-316.
  • 24. Oral cancer Incidence Statistics. Cancer Research UK; 2010. Available from: http://www.cancerresearchuk.org/.
  • 25. Friedlander PL, Schantz SP, Shaha AR, Yu G, Shah JP. Squamous cell carcinoma of the tongue in young patients: a matched-pair analysis. Head Neck. 1998; 20: 363-368.
  • 26. Llewellyn CD, Johnson NW, Warnakulasuriya KAAS. Risk factors for squamous cell carcinoma of the oral cavity in young people – a comprehensive literature review. Oral Oncol. 2001; 37: 401-418.
  • 27. Feller L, Lemmer J. Oral Squamous Cell Carcinoma: Epidemiology, Clinical Presentation and Treatment. Journal of Cancer Therapy. 2012; (3): 263-268. 28. La Vecchia C, Lucchini F, Negri E, Levi F. Trends in oral cancer mortality in Europe. Oral Oncol. 2004; 40(4): 433-439. 29. Ferreira Antunes JL, Toporcov TN, Biazevic MG, Boing AF, Scully C, Petti S. Joint and independent effects of alcohol drinking and tobacco smoking on oral cancer: a large case–control study. PLoS One. 2013; 8(7): e68132. 30. Hashibe M, Brennan P, Benhamou S, Castellsague X, Chen C, Curado MP, Dal Maso L, Daudt AW, Fabianova E, Fernandez L, Wünsch-Filho V, Franceschi S, Hayes RB, Herrero R, Koifman S, La Vecchia C, Lazarus P, Levi F, Mates D, Matos E, Menezes A, Muscat J, Eluf-Neto J, Olshan AF, Rudnai P, Schwartz SM, Smith E, Sturgis EM, Szeszenia-Dabrowska N, Talamini R, Wei Q, Winn DM, Zaridze D, Zatonski W, Zhang ZF, Berthiller J, Boffetta P. Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. J Natl Cancer Inst. 2007; 99(10): 777-789.
  • 31. Castellsague X, Quintana MJ, Martinez MC, Nieto A, Sanchez MJ, Juan A, Monner A, Carrera M, Agudo A, Quer M, Muñoz N, Herrero R, Franceschi S, Bosch FX. The role of type of tobacco and type of alcoholic beverage in oral carcinogenesis. Int J Cancer. 2004; 108(5): 741-749.
  • 32. Curado MP, Hashibe M. Recent changes in the epidemiology of head and neck cancer. Curr Opin Oncol. 2009; 21(3): 194-200.
  • 33. Wünsch-Filho V. The epidemiology of oral and pharynx cancer in Brazil. Oral Oncol. 2002; 38(8): 737-746. 34. Basu R, Mandal S, Ghosh A, Poddar TK. Role of tobacco in the development of head and neck squamous cell carcinoma in an eastern Indian population. Asian Pac J Cancer Prev. 2008; 9: 381 386.
  • 35. Martin HE. Cancer of the gums (gingivae). Am J Surg.1941; 54: 769- 806. 36. Shafer WG, Hine MK, Levy BM. A Textbook of Oral Pathology, 4th ed. Philadelphia: WB Saunders; 1983. p. 124-126.
  • 37. Joseph AR, James JS. Oral Pathology: Clinical Pathologic Correlations, 3rd ed. Philadelphia: WB Saunders; 1999. p.69-81. 38. Rikardsen OG, Bjerkli IH, Lars Uhlin-Hansen L, Hadler-Olsen E, Steigen SE. Clinicopathological characteristics of oral squamous cell carcinoma in Northern Norway: a retrospective study. BMC Oral Health. 2014; 14: 103.
  • 39. Bello IO, Soini Y, Salo T. Prognostic evaluation of oral tongue cancer: means, markers and perspectives (I). Oral Oncol. 2010; 46(9): 630-635.
  • 40. Neville BW, Day TA. Oral cancer and precancerous lesions. CA Cancer J Clin. 2002; 52(4): 195-215.
  • 41. Scully C, Bagan J. Oral squamous cell carcinoma overview. Oral Oncol. 2009; 45(4-5): 301-308.
  • 42. Tyagi N, Tyagi R. Squamous cell carcinoma (well differentiated):A case report J. Dent. Oral Hyg. 2013; 5(4): 31-34.
  • 43. Neville BW, Damm DD, Allen C, Bouquet J. Oral and Maxillofacial Pathology, 2nd ed. Elsevier; 2008. p.451-452.
Toplam 34 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm Case Report
Yazarlar

Gaye Keser Bu kişi benim

Filiz Namdar Bu kişi benim

Semih Ozbayrak Bu kişi benim

Canan Alatlı Bu kişi benim

Yayımlanma Tarihi 29 Aralık 2015
Gönderilme Tarihi 10 Haziran 2015
Yayımlandığı Sayı Yıl 2015 Cilt: 5 Sayı: 4

Kaynak Göster

APA Keser, G., Namdar, F., Ozbayrak, S., Alatlı, C. (2015). Gingivanın Skuamöz Hücreli Karsinomu: Vaka Sunumu ve Literatür Taraması. Clinical and Experimental Health Sciences, 5(4), 290-295. https://doi.org/10.5455/musbed.20150831012106
AMA Keser G, Namdar F, Ozbayrak S, Alatlı C. Gingivanın Skuamöz Hücreli Karsinomu: Vaka Sunumu ve Literatür Taraması. Clinical and Experimental Health Sciences. Aralık 2015;5(4):290-295. doi:10.5455/musbed.20150831012106
Chicago Keser, Gaye, Filiz Namdar, Semih Ozbayrak, ve Canan Alatlı. “Gingivanın Skuamöz Hücreli Karsinomu: Vaka Sunumu Ve Literatür Taraması”. Clinical and Experimental Health Sciences 5, sy. 4 (Aralık 2015): 290-95. https://doi.org/10.5455/musbed.20150831012106.
EndNote Keser G, Namdar F, Ozbayrak S, Alatlı C (01 Aralık 2015) Gingivanın Skuamöz Hücreli Karsinomu: Vaka Sunumu ve Literatür Taraması. Clinical and Experimental Health Sciences 5 4 290–295.
IEEE G. Keser, F. Namdar, S. Ozbayrak, ve C. Alatlı, “Gingivanın Skuamöz Hücreli Karsinomu: Vaka Sunumu ve Literatür Taraması”, Clinical and Experimental Health Sciences, c. 5, sy. 4, ss. 290–295, 2015, doi: 10.5455/musbed.20150831012106.
ISNAD Keser, Gaye vd. “Gingivanın Skuamöz Hücreli Karsinomu: Vaka Sunumu Ve Literatür Taraması”. Clinical and Experimental Health Sciences 5/4 (Aralık 2015), 290-295. https://doi.org/10.5455/musbed.20150831012106.
JAMA Keser G, Namdar F, Ozbayrak S, Alatlı C. Gingivanın Skuamöz Hücreli Karsinomu: Vaka Sunumu ve Literatür Taraması. Clinical and Experimental Health Sciences. 2015;5:290–295.
MLA Keser, Gaye vd. “Gingivanın Skuamöz Hücreli Karsinomu: Vaka Sunumu Ve Literatür Taraması”. Clinical and Experimental Health Sciences, c. 5, sy. 4, 2015, ss. 290-5, doi:10.5455/musbed.20150831012106.
Vancouver Keser G, Namdar F, Ozbayrak S, Alatlı C. Gingivanın Skuamöz Hücreli Karsinomu: Vaka Sunumu ve Literatür Taraması. Clinical and Experimental Health Sciences. 2015;5(4):290-5.

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