Kök Rezorbsiyonuna Neden Olan Santral Dev Hücreli Granülom: Vaka Raporu

Yıl 2015, Cilt: 5 Sayı: 4, 296 - 300, 29.12.2015

Mustafa Gumusok Begum Okur Oguzhan Demırel Emre Barıs Meryem Toraman Ozlem Ucok

https://doi.org/10.5455/musbed.20150831013034

Öz

Santral dev hücreli granulom (SDHG) çenelerde görülen tüm selim lez¬yonların %7’sinden daha azını oluşturan, yaygın olmayan, kemik içi lez¬yonlardır. SDHG’ye mandibulada, maksilladan ve kadınlarda erkeklerden daha sık rastlanır. Hastalar daha çok 30 yaş altı bireylerdir. Klinik olarak asemptomatik, yavaş seyirli, osteolitik lezyonlardan, ağrılı, kortikal kemik destrüksüyonu ve diş rezorpsiyonuna neden olabilen agresif lezyonlara kadar geniş bir dağılım gösterirler. Etyolojileri çok açık olmamakla birlik¬te hemoraji, enflamasyon, genetik ve lokal travmanın etken olabileceği düşünülmektedir.
Bu vaka raporunda, 44 yaşında kadın hastanın sağ mandibula posterior böl¬gesinde görülen, kortikal kemikte destrüksüyona ve dişte rezorbsiyona neden olan SDHG vakası, teşhis, tedavi ve bir yıllık takibi ile birlikte sunulmuştur.

Anahtar Kelimeler

Santral dev hücreli granülom, mandibula, diş resorbsiyonu

Central Giant Cell Granuloma Causing Tooth Resorption: a Case Report

Öz

Central giant cell granuloma (CGCG) is a relatively uncommon benign intraosseous lesion comprising for less than 7% of all benign lesions of the jaws. CGCG is seen more frequently in mandible than maxilla and in females than males. Patients are generally younger than 30 years. The clinical behavior of the lesion varies from an asymptomatic osteolytic lesion that grows slowly, to an aggressive, painful process accompanied by teeth resorption, cortical bone destruction. Aetiology of CGCG is still unclear, although haemorrhage, inflammation, genetic and local trauma have been considered.
In this case report, CGCG of a 44 years old female located on her right mandible causing perforation of alveolar bone and tooth resorption is presented. The diagnosis, treatment and one year follow-up after surgery is reported.

Anahtar Kelimeler

Central giant cell granuloma, mandible, tooth resorption

Kaynakça

• 1. Jaffe H. Giant-cell reparative granuloma, traumatic bone cyst, and fibrous (fibro-oseous) dysplasia of the jaw bones. Oral Surg Oral Med Oral Pathol. 1953; 6: 159-175. 2. Telcioğlu NT, Sümer M, Eğilmez T, Karagöz F. Santral Dev Hücreli Granülom. Turkiye Klinikleri J Dental Sci. 2009; 15: 64-68.
• 3. Jadu FM, Pharoah MJ, Lee L, Baker GI, Allidina A. Central giant cell granuloma of the mandibular condyle: a case report and review of the literatüre. Dentomaxillofac Radiol. 2011; 40: 60-64.
• 4. Öztürk S, Zor F, Şahin İ, Öztürk S, Deveci M, Işık S. Mandibulanın santral dev hücreli granülomu: olgu sunumu. Gülhane Tıp Derg. 2011; 53: 123- 125.
• 5. White S and Pharoah M. Oral radiology: principles and interpretation. 6th ed. St. Louis, MO: Mosby; 2009.p.443.
• 6. deLange J, van den Akker HP, van den Berg H. Central giant cell granuloma of the jaw: a review of the literature with emphasis on the rapyoptions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007; 104: 603-615.
• 7. deLange J, vanMaarle MC, van den Akker HP, Redeker EJ. DNA analysis of the SH3BP2 gene in patients with aggressive, central giant cell granuloma. Br J Oral Maxillofac Surg. 2007; 45: 499-500.
• 8. deLange J, van den Akker HP, Klip H. Incidence and disease-free survival after surgical therapy of central giant cell granulomas of the jaw in The Netherlands: 1990-1995. Head Neck. 2004; 26: 792-795.
• 9. Aras MH, Demirkol M, Kara Mİ, Ay S. Santral Dev Hücreli Granülomalar ve Hiperparatiroidizm ile İlişkisi. Turkiye Klinikleri J Dental Sci. 2012; 18: 45-50. 10. Kaffe I, Ardekian L, Taicher S, Littner MM, Buchner A Radiologic features of central giant cell granuloma of the jaws. Oral Surg Oral Med Oral Pathol Oral Radiol Endod.1996; 81: 720-726. 11. Chuong R, Kaban L, Kozakewich H, Perez-Atayde A. Central giant cell lesions of the jaws: a clinic opathologic study. J Oral Maxillofac Surg. 1986; 44: 708-713.
• 12. Ficarra G, Kaban L, Hansen L. Central giant cell lesions of the mandible and maxilla: a clinic opathologic and cytometric study. Oral Surg Oral Med Oral Pathol. 1987; 64: 44-49.
• 13. Stavropoulos F, Katz J. Central giant cell granulomas: a systematic review of the radiographic characteristics witht headdition of 20 new cases. Dento maxillofacial Radiology. 2002; 31: 213-217.
• 14. Abu-El-Naaj I, Ardekian L, Liberman R, Peled M. Central giant cell granuloma of the mandibular condyle: a rarepresentation. J Oral Maxillofac Surg. 2002;60:939-941.
• 15. Neville B, Damm D, Allen C, Bouquot J. Bone pathology. Oral and maxillofacial pathology. 2nd ed. Philadelphia, PA: W.B. Saunders Company; 2002.p.544-547.
• 16. Hıdır Y, Durmaz A, Deveci MS, Ulus S, Gerek M. Maksiller Santral Dev Hücreli Granüloma: Olgu Sunumu. KBB ve BBC Dergisi. 2011; 19: 47-50.
• 17. Allon DM, Anavi Y, Calderon S. Central giant cell lesion of the jaw: non surgical treatment with calcitonin nasalspray. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009; 107: 811-818.
• 18. Harris M. Central giant cell granulomas of the jaws regress with calcitonin therapy. Br J Oral Maxillofac Surg. 1993; 31: 89-94.
• 19. deLange J, van den Akker HP, van den Berg H, Richel DJ, Gortzak RA. Limited regression of central giant cell granulomaby interferon alpha after failed calcitonin therapy: a report of 2 cases. Int J Oral Maxillofac Surg. 2006; 35: 865-869.
• 20. LarheimTA, Westesson PL. Benign Jaw Tumorsand Tumor Like Conditions. MaxillofacialImaging. 1st ed. Berlin Heidelberg: Springer; 2006.p.76.
• 21. White S, Pharoah M. Diseases of Bone Manifested in the Jaws. Oral radiology: principles and interpretation. 6th ed. St. Louis, MO: Mosby; 2009.p. 444. 22. Stewart JSC. Benign Nonodontogenic Tumors. In: Regezi JA, Sciuubba J, eds. Oral Pathology Clinical-Pathologic Correlations, 4nd ed. Philadelphia: Saunders; 2003.p. 301.