The Role of Omega-3 and Antioxidant Nutrients in Age-Related Macular Degeneration: A Review Article
Yıl 2022,
Cilt: 12 Sayı: 2, 548 - 555, 30.06.2022
Emine Koçyiğit
,
Nilüfer Acar Tek
Öz
Age-related macular degeneration (AMD) is the most common cause of irreversible vision loss worldwide. The cause of the disease is not well explained; studies previse a multifactorial etiology. Various results of studies suggest that omega-3 fatty acids may have beneficial effects in AMD. Besides the omega-3, clinical evidence showed that specific micronutrients (antioxidant vitamins and minerals) protect against AMD. The definition of risk factors for the development and progression of AMD is important for understanding the causes of the disorder and for the determination of its prevention strategies. In this study, the relationship between omega 3 and antioxidant nutrients and the incidence and progression of AMD were evaluated.
Kaynakça
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De Jong P, Nemesure B, Mitchell P, Kempen J. Prevalence of
age-related macular degeneration in the United States. Arch
ophthalmol 2004;122(4):564-572.
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clinical review and genetics update. Clin Genet 2013;84(2):160-
166.
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cardiovascular disease phenotypes and lipid factors. Eye Vis
(Lond) 2016;3(1):34.
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TY. Global prevalence of age-related macular degeneration
and disease burden projection for 2020 and 2040: a
systematic review and meta-analysis. Lancet Glob Health
2014;2(2):e106-e116.
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2010. Br J Ophthalmol 2012;96(5):614-618.
- [6] Al Gwairi O, Thach L, Zheng W, Osman N, Little PJ.
Cellular and molecular pathology of age-related macular
degeneration: potential role for proteoglycans. J Ophthalmol
2016;2016:2913612.
- [7] Fritsche LG, Fariss RN, Stambolian D, Abecasis GR, Curcio CA,
Swaroop A. Age-related macular degeneration: genetics and
biology coming together. Annu Rev Genomics Hum Genet
2014;15:151-171.
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degeneration. N Engl J Med 2008;358(24):2606-2617.
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RE. Fifteen-year cumulative incidence of age-related macular
degeneration: the Beaver Dam Eye Study. Ophthalmology
2007;114(2):253-262.
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prevention. UpToDate, Waltham, MA 2020;1(1):1-12.
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E. Micronutrients in age-related macular degeneration.
Ophthalmologica 2013;229(2):75-79.
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placebo-controlled, clinical trial of high-dose supplementation
with vitamins C and E, beta carotene, and zinc for age-related
macular degeneration and vision loss: AREDS report no. 8.
Arch Ophthalmol 2001;119(10):1417.
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Prospective study of intake of fruits, vegetables, vitamins,
and carotenoidsand risk of age-related maculopathy. Arch
Ophthalmol 2004;122(6):883-892.
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Dong PC, Xiao X. Effect of lutein and zeaxanthin on macular
pigment and visual function in patients with early age-related
macular degeneration. Ophthalmology 2012;119(11):2290-
2297.
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Lindblad A, Milton R, Seddon J, Sperduto R. The relationship
of dietary carotenoid and vitamin A, E, and C intake with age related macular degeneration in a case-control study. Arch Ophthalmol 2007;125(9):1225-1232.
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age-related macular degeneration. Mol Aspects Med
2012;33(4):318-375.
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M, De Jong P, Klaver C, Klein B, Klein R. An international
classification and grading system for age-related maculopathy
and age-related macular degeneration. Surv Ophthalmol
1995;39(5):367-374.
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grading and prevalence of macular degeneration in Chesapeake
Bay watermen. Arch ophthalmol 1989;107(6):847-852.
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eye disease study research. Risk factors for the incidence of
advanced age-related macular degeneration in the Age Related Eye Disease Study (AREDS) AREDS report no. 19. Ophthalmology 2005;112(4):533-539.
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local inflammation in the formation of drusen in the aging eye.
Am J Ophthalmol 2002;134(3):411-431.
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in age-related macular disease. Graefes Arch Clin Exp
Ophthalmol 2004;242(8):710-716.
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Pathogenesis and therapy. Pharmacol Rep 2006;58(3):353-
363.
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of age-related macular degeneration. Am J Ophthalmol
2004;137(3):486-495.
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macular degeneration. Scott Med J 2012;1(2).
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F, Féart C, Le Goff M, Dartigues JF, Barberger-Gateau P. Dietary
omega-3 fatty acids and the risk for age-related maculopathy:
the Alienor Study. Invest Ophthalmol Vis Sci 2011;52(8):6004-
6011.
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fatty acids, other fat intake, genetic susceptibility, and
progression to incident geographic atrophy. Ophthalmology
2013;120(5):1020-1028.
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disease. Am J Clin Nutr 2000;71(1):171S-175S.
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slowing the progression of age-related macular degeneration.
Cochrane Database Syst Rev 2015;(4):CD010015.
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EH. Circulating omega-3 fatty acids and neovascular age related macular degeneration. Invest Ophthalmol Vis Sci 2014;55(3):2010-2019.
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polyunsaturated fatty acids in health and disease of the retina.
Prog Retin Eye Res 2005;24(1):87-138.
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Crohns disease. Gastroenterol Nurs 2006;29(4):295-301; quiz
302-293.
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between C-reactive protein and age-related macular
degeneration. JAMA 2004;291(6):704-710.
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acids exert immunomodulatory effects on lymphocytes by
targeting plasma membrane molecular organization. Mol
Aspects Med 2012;33(1):46-54.
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Data base: The German Food Code and Nutrient Data Base
(BLS II.3, 1999) with additions from USDA-sr and other sources.
Istanbul: 2004. Stuttgart, Germany:Hohenhim University.
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ω-3 fatty acid and fish intake and incident age-related macular
degeneration in women. Arch Ophthalmol 2011;129(7):921-
929.
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of fish and shellfish consumption on age-related macular
degeneration. Ophthalmology 2010;117(12):2395-2401.
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Bentham G, Rahu M, Seland J, Soubrane G, Tomazzoli
L. Oily fish consumption, dietary docosahexaenoic acid
and eicosapentaenoic acid intakes, and associations with
neovascular age-related macular degeneration. Am J Clin Nutr
2008;88(2):398-406.
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S, Hashimoto H, Sasaki S, Yanagi Y. Dietary n-3 fatty acid,
α-tocopherol, zinc, vitamin D, vitamin C, and β-carotene are
associated with age-related macular degeneration in Japan.
Sci Rep 2016;6:20723.
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Gensler G, Lindblad AS, Milton RC, Seddon JM, Klein R. The
relationship of dietary ω-3 long-chain polyunsaturated fatty
acid intake with incident age-related macular degeneration:
AREDS report no. 23. Arch Ophthalmol 2008;126(9):1274-
1279.
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GR, Kurinij N, Lindhlad AS, Seddon JM, Sperduto RD. The
relationship of dietary lipid intake and age-related macular
degeneration. Arch Ophthalmol 2007;125671:679.
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10-year incidence of age-related macular degeneration: the
Blue Mountains Eye Study. Arch Ophthalmol 2009;127(5):656-
665.
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Yıl 2022,
Cilt: 12 Sayı: 2, 548 - 555, 30.06.2022
Emine Koçyiğit
,
Nilüfer Acar Tek
Kaynakça
- [1] Friedman DS, O’Colmain BJ, Munoz B, Tomany SC, McCarty C,
De Jong P, Nemesure B, Mitchell P, Kempen J. Prevalence of
age-related macular degeneration in the United States. Arch
ophthalmol 2004;122(4):564-572.
- [2] Ratnapriya R, Chew EY. Age-related macular degeneration—
clinical review and genetics update. Clin Genet 2013;84(2):160-
166.
- [3] Pennington KL, DeAngelis MM. Epidemiology of age related macular degeneration (AMD): associations with
cardiovascular disease phenotypes and lipid factors. Eye Vis
(Lond) 2016;3(1):34.
- [4] Wong WL, Su X, Li X, Cheung CMG, Klein R., Cheng CY, Wong
TY. Global prevalence of age-related macular degeneration
and disease burden projection for 2020 and 2040: a
systematic review and meta-analysis. Lancet Glob Health
2014;2(2):e106-e116.
- [5] Pascolini D, Mariotti SP. Global estimates of visual impairment:
2010. Br J Ophthalmol 2012;96(5):614-618.
- [6] Al Gwairi O, Thach L, Zheng W, Osman N, Little PJ.
Cellular and molecular pathology of age-related macular
degeneration: potential role for proteoglycans. J Ophthalmol
2016;2016:2913612.
- [7] Fritsche LG, Fariss RN, Stambolian D, Abecasis GR, Curcio CA,
Swaroop A. Age-related macular degeneration: genetics and
biology coming together. Annu Rev Genomics Hum Genet
2014;15:151-171.
- [8] Gehrs KM, Anderson DH, Johnson LV, Hageman GS. Age related macular degeneration—emerging pathogenetic and therapeutic concepts. Ann Med 2006;38(7):450-471.
- [9] Jager RD, Mieler WF, Miller JW. Age-related macular
degeneration. N Engl J Med 2008;358(24):2606-2617.
- [10] Klein R, Klein BE, Knudtson MD, Meuer SM, Swift M, Gangnon
RE. Fifteen-year cumulative incidence of age-related macular
degeneration: the Beaver Dam Eye Study. Ophthalmology
2007;114(2):253-262.
- [11] Arroyo JG. Age-related macular degeneration: Treatment and
prevention. UpToDate, Waltham, MA 2020;1(1):1-12.
- [12] Aslam T, Delcourt C, Silva R, Holz FG, Leys A, Layana AG, Souied
E. Micronutrients in age-related macular degeneration.
Ophthalmologica 2013;229(2):75-79.
- [13] Age-Related Eye Disease Study (AREDS) Group. A randomized,
placebo-controlled, clinical trial of high-dose supplementation
with vitamins C and E, beta carotene, and zinc for age-related
macular degeneration and vision loss: AREDS report no. 8.
Arch Ophthalmol 2001;119(10):1417.
- [14] Cho E, Seddon JM, Rosner B, Willett WC, Hankinson SE.
Prospective study of intake of fruits, vegetables, vitamins,
and carotenoidsand risk of age-related maculopathy. Arch
Ophthalmol 2004;122(6):883-892.
- [15] Ma L, Yan SF, Huang YM, Lu XR, Qian F, Pang HL, Xu XR, Zou ZY,
Dong PC, Xiao X. Effect of lutein and zeaxanthin on macular
pigment and visual function in patients with early age-related
macular degeneration. Ophthalmology 2012;119(11):2290-
2297.
- [16] SanGiovanni JP, Chew EY, Clemons TE, Ferris 3rd F, Gensler G,
Lindblad A, Milton R, Seddon J, Sperduto R. The relationship
of dietary carotenoid and vitamin A, E, and C intake with age related macular degeneration in a case-control study. Arch Ophthalmol 2007;125(9):1225-1232.
- [17] Weikel KA, Chiu CJ, Taylor A. Nutritional modulation of
age-related macular degeneration. Mol Aspects Med
2012;33(4):318-375.
- [18] Bird AC, Bressler NM, Bressler SB, Chisholm I, Coscas G, Davis
M, De Jong P, Klaver C, Klein B, Klein R. An international
classification and grading system for age-related maculopathy
and age-related macular degeneration. Surv Ophthalmol
1995;39(5):367-374.
- [19] Bressler NM, Bressler SB, West SK, Fine SL, Taylor HR. The
grading and prevalence of macular degeneration in Chesapeake
Bay watermen. Arch ophthalmol 1989;107(6):847-852.
- [20] Clemons T, Milton R, Klein R, Seddon J, Ferris 3rd F. Age-related
eye disease study research. Risk factors for the incidence of
advanced age-related macular degeneration in the Age Related Eye Disease Study (AREDS) AREDS report no. 19. Ophthalmology 2005;112(4):533-539.
- [21] Anderson DH, Mullins RF, Hageman GS, Johnson LV. A role for
local inflammation in the formation of drusen in the aging eye.
Am J Ophthalmol 2002;134(3):411-431.
- [22] Roth F, Bindewald A, Holz FG. Keypathophysiologic pathways
in age-related macular disease. Graefes Arch Clin Exp
Ophthalmol 2004;242(8):710-716.
- [23] Nowak JZ. Age-related macular degeneration (AMD):
Pathogenesis and therapy. Pharmacol Rep 2006;58(3):353-
363.
- [24] Carneiro A. Nutrition and the ageing eye. Neves D, editor. Anti ageing nutrients: Evidence-based prevention of age-associated diseases. New York: John Wiley & Sons; 2015.p.277-291.
- [25] Klein R, Peto T, Bird A, Vannewkirk MR. The epidemiology
of age-related macular degeneration. Am J Ophthalmol
2004;137(3):486-495.
- [26] Porte C. Pathogenesis and management of age-related
macular degeneration. Scott Med J 2012;1(2).
- [27] Merle B, Delyfer MN, Korobelnik JF, Rougier MB, Colin J, Malet
F, Féart C, Le Goff M, Dartigues JF, Barberger-Gateau P. Dietary
omega-3 fatty acids and the risk for age-related maculopathy:
the Alienor Study. Invest Ophthalmol Vis Sci 2011;52(8):6004-
6011.
- [28] Reynolds R, Rosner B, Seddon JM. Dietary omega-3
fatty acids, other fat intake, genetic susceptibility, and
progression to incident geographic atrophy. Ophthalmology
2013;120(5):1020-1028.
- [29] Connor WE. Importance of n− 3 fatty acids in health and
disease. Am J Clin Nutr 2000;71(1):171S-175S.
- [30] Lawrenson JG, Evans JR. Omega 3 fatty acids for preventing or
slowing the progression of age-related macular degeneration.
Cochrane Database Syst Rev 2015;(4):CD010015.
- [31] Merle BM, Benlian P, Puche N, Bassols A, Delcourt C, Souied
EH. Circulating omega-3 fatty acids and neovascular age related macular degeneration. Invest Ophthalmol Vis Sci 2014;55(3):2010-2019.
- [32] SanGiovanni JP, Chew EY. The role of omega-3 long-chain
polyunsaturated fatty acids in health and disease of the retina.
Prog Retin Eye Res 2005;24(1):87-138.
- [33] MacDonald A. Omega-3 fatty acids as adjunctive therapy in
Crohns disease. Gastroenterol Nurs 2006;29(4):295-301; quiz
302-293.
- [34] Seddon JM, Gensler G, Milton RC, Klein ML, Rifai N. Association
between C-reactive protein and age-related macular
degeneration. JAMA 2004;291(6):704-710.
- [35] Shaikh SR, Jolly CA, Chapkin RS. n− 3 Polyunsaturated fatty
acids exert immunomodulatory effects on lymphocytes by
targeting plasma membrane molecular organization. Mol
Aspects Med 2012;33(1):46-54.
- [36] Bebis (Beslenme Bilgi Sistemi) Nutrition Data Base Software.
Data base: The German Food Code and Nutrient Data Base
(BLS II.3, 1999) with additions from USDA-sr and other sources.
Istanbul: 2004. Stuttgart, Germany:Hohenhim University.
- [37] Christen WG, Schaumberg DA, Glynn RJ, Buring JE. Dietary
ω-3 fatty acid and fish intake and incident age-related macular
degeneration in women. Arch Ophthalmol 2011;129(7):921-
929.
- [38] Swenor BK, Bressler S, Caulfield L, West SK. The impact
of fish and shellfish consumption on age-related macular
degeneration. Ophthalmology 2010;117(12):2395-2401.
- [39] Augood C, Chakravarthy U, Young I, Vioque J, de Jong PT,
Bentham G, Rahu M, Seland J, Soubrane G, Tomazzoli
L. Oily fish consumption, dietary docosahexaenoic acid
and eicosapentaenoic acid intakes, and associations with
neovascular age-related macular degeneration. Am J Clin Nutr
2008;88(2):398-406.
- [40] Aoki A, Inoue M, Nguyen E, Obata R, Kadonosono K, Shinkai
S, Hashimoto H, Sasaki S, Yanagi Y. Dietary n-3 fatty acid,
α-tocopherol, zinc, vitamin D, vitamin C, and β-carotene are
associated with age-related macular degeneration in Japan.
Sci Rep 2016;6:20723.
- [41] SanGiovanni JP, Chew EY, Agron E, Clemons TE, Ferris FL,
Gensler G, Lindblad AS, Milton RC, Seddon JM, Klein R. The
relationship of dietary ω-3 long-chain polyunsaturated fatty
acid intake with incident age-related macular degeneration:
AREDS report no. 23. Arch Ophthalmol 2008;126(9):1274-
1279.
- [42] SanGiovanni S, Emiły Y, Chew M, Clemons TE, Gensler
GR, Kurinij N, Lindhlad AS, Seddon JM, Sperduto RD. The
relationship of dietary lipid intake and age-related macular
degeneration. Arch Ophthalmol 2007;125671:679.
- [43] Tan JS, Wang JJ, Flood V, Mitchell P. Dietary fatty acids and the
10-year incidence of age-related macular degeneration: the
Blue Mountains Eye Study. Arch Ophthalmol 2009;127(5):656-
665.
- [44] Zhu W, Wu Y, Meng Y-F, Xing Q, Tao J-J, Lu J. Fish consumption
and age-related macular degeneration incidence: A meta analysis and systematic review of prospective cohort studies. Nutrients 2016;8(11):743.
- [45] Age-Related Eye Disease Study (AREDS) Group. Lutein +
zeaxanthin and omega-3 fatty acids for age-related macular
degeneration: the Age-Related Eye Disease Study 2 (AREDS2)
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