Araştırma Makalesi
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Psychological Morbidity, Fatigue and Burden of Disease in Patients With Connective Tissue Diseases

Yıl 2022, Cilt 12, Sayı 2, 285 - 293, 30.06.2022
https://doi.org/10.33808/clinexphealthsci.983685

Öz

Objective: Depression and anxiety disorders are significant health problems that can coexist with other diseases and exert adverse effects on these diseases’ course and treatment response. Fatigue is a common and disabling symptom in chronic inflammatory diseases. The present study aimed to evaluate the fatigue, anxiety, depression and burden of disease (eg, disease activity, function, quality of life) in autoimmune connective tissue disease (CTD) patients. Methods: 160 patients diagnosed with CTD and 50 healthy control patients were included in the present study. Disease activity scores were recorded. All patients were asked to fill the Short Form-36, Fatigue Severity Scale, Hospital Depression and Anxiety Scale (HADS). Results: In all patients groups, anxiety, depression, and fatigue scores were significantly higher, and quality of life scores significantly lower than those of healthy controls. A significant positive correlation was found between rheumatoid arthritis activity, HADS anxiety and depression scores. It was also established that in scleroderma patients with diffuse skin involvement and pulmonary involvement, depression and anxiety scores were high. Conclusion: It is clear that psychiatric comorbidity and fatigue may be present in CTD and adversely affects quality of life. It is important to assess them and they should be an important treatment target.

Kaynakça

  • [1] Varan Ö, Babaoğlu H, Göker B. Associations between depressive disorders and inflammatory rheumatic diseases. Curr Top Med Chem 2018; 18(16):1395-1401.
  • [2] Lisitsyna TA, Veltishchev DY, Seravina OF, Kovalevskaya OB, Starovoytova MN, Desinova OV, et al. Comparative analysis of anxiety-depressive spectrum disorders in patients with rheumatic diseases. Ter Arkh 2018; 90(5):30-37.
  • [3] Gök K, Cengiz G, Erol K, Özgöçmen S. The Turkish version of multidimensional assessment of fatigue and fatigue severity scale is reproducible and correlated with other outcome measures in patients with systemic sclerosis. Arch Rheumatol 2016; 31(4):329-332.
  • [4] Grygiel-Górniak B, Limphaibool N, Puszczewicz M. Cytokine secretion and the risk of depression development in patients with connective tissue diseases. Psychiatry Clin Neurosci 2019; 73(6):302-316.
  • [5] Ware J, Snow K, Kosinski M, Gandek B. SF-36 health survey. Manual and interpretation guide. Boston, MA: New England Medical Center The Health Institute. 1993; 98(1-2):91-97.
  • [6] Aydemir O. Validity and reliability of Turkish version of hospital anxiety and depression scale. Turkish Journal of Psychiatry 1997; 8(4):280-287
  • [7] Tarakçı E, Arman N, Barut K, Şahin S, Adroviç A, Kasapçopur Ö. Fatigue and sleep in children and adolescents with juvenile idiopathic arthritis: a cross-sectional study. Turk J Med Sci 2019; 49(1):58-65.
  • [8] Kojima M, Kojima T, Waguri-Nagaya Y, Takahashi N, Asai S, Sobue Y. Depression, physical function, and disease activity associated with frailty in patients with rheumatoid arthritis. Mod Rheumatol 2021; 31(5):979-986
  • [9] Imran MY, Saira Khan EA, Ahmad NM, Farman Raja S, Saeed MA, Ijaz Haider I. Depression in rheumatoid arthritis and its relation to disease activity. Pak J Med Sci 2015; 31(2):393-7.
  • [10] Figueiredo-Braga M, Cornaby C, Cortez A, Bernardes M, Terroso G, Figueiredo M. Influence of biological therapeutics, cytokines, and disease activity on depression in rheumatoid arthritis. J Immunol Res 2018; 2018:5954897.
  • [11] Žagar I, Delimar V, Pap M, Perić D, Laktašić Žerjavić N, Perić P. Prevalence and correlation of depressive symptoms with functional scores, therapy and disease activity among Croatian patients with rheumatoid arthritis: a preliminary study. Psychiatr Danub 2018; 30 (4):452-458.
  • [12] Englbrecht M, Alten R, Aringer M, Baerwald CG, Burkhardt H, Eby N. New insights into the prevalence of depressive symptoms and depression in rheumatoid arthritis – Implications from the prospective multicenter VADERA II study. PLoS One 2019; 14(5):e0217412.
  • [13] Gök K, Erol K, Cengiz G, Özgöçmen S. Comparison of level of fatigue and disease correlates in patients with rheumatoid arthritis and systemic sclerosis. Arch Rheumatol. 2018; 33(3):316-321.
  • [14] Tay SH, Cheung PP, Mak A. Active disease is independently associated with more severe anxiety rather than depressive symptoms in patients with systemic lupus erythematosus. Lupus 2015; 2 4(13):1392-1399.
  • [15] Skinner-Taylor CM, Perez-Barbosa L, Corral-Trujillo ME, Perez- Onofre I, Barriga-Maldonado ES, Cardenas-de la Garza JA. Anxiety and depression in reproductive age women with rheumatic diseases. Rheumatol Int 2020; 40(9):1433-1438.
  • [16] Azizoddin DR, Gandhi N, Weinberg S, Sengupta M, Nicassio PM, Jolly M. Fatigue in systemic lupus: the role of disease activity and its correlates. Lupus. 2019; 28(2):163-173.
  • [17] Alsowaida N, Alrasheed M, Mayet A, Alsuwaida A, Omair MA. Medication adherence, depression, and disease activity among patients with systemic lupus erythematosus. Lupus 2018; 27(2):327-332
  • [18] Margiotta DPE, Fasano S, Basta F, Pierro L, Riccardi A, Navarini L. Clinical features of patients with systemic lupus erythematosus according to health-related quality of life, entity of pain, fatigue and depression: a cluster analysis. Clin Exp Rheumatol 2019; 37(4):535-539.
  • [19] Margiotta DPE, Fasano S, Basta F, Pierro L, Riccardi A, Navarini L. The association between duration of remission, fatigue, depression and health-related quality of life in Italian patients with systemic lupus erythematosus. Lupus 2019; 28(14):1705- 1711.
  • [20] Choi ST, Kang JI, Park IH, Lee YW, Song JS, Park YB. Subscale analysis of quality of life in patients with systemic lupus erythematosus: association with depression, fatigue, disease activity and damage. Clin Exp Rheumatol 2012; 30(5):665-72.
  • [21] Arnaud L, Mertz P, Amoura Z, Voll RE, Schwarting A, Maurier F. Patterns of fatigue and association with disease activity and clinical manifestations in systemic lupus erythematosus. Rheumatology (Oxford) 2020; 60(6):2672-2677
  • [22] Yilmaz-Oner S, Oner C, Dogukan FM, Moses TF, Demir K, Tekayev N. Anxiety and depression predict quality of life in Turkish patients with systemic lupus erythematosus. Clin Exp Rheumatol 2015; 33(3):360-5.
  • [23] Mok CC, Chan KL, Ho LY. Association of depressive/anxiety symptoms with quality of life and workability in patients with systemic lupus erythematosus. Clin Exp Rheumatol 2016; 34(3):389-95.
  • [24] Cui Y, Xia L, Li L, Zhao Q, Chen S, Gu Z. Anxiety and depression in primary Sjögren’s syndrome: a cross-sectional study. BMC Psychiatry 2018; 18(1):131.
  • [25] Milin M, Cornec D, Chastaing M, Griner V, Berrouiguet S, Nowak E, Marhadour T, Saraux A, Devauchelle-Pensec V. Sicca symptoms are associated with similar fatigue, anxiety, depression, and quality-of-life impairments in patients with and without primary Sjögren’s syndrome. Joint Bone Spine 2016; 83(6):681-685.
  • [26] Koçer B, Tezcan ME, Batur HZ, Haznedaroğlu Ş, Göker B, İrkeç C. Cognition, depression, fatigue, and quality of life in primary Sjögren’s syndrome: correlations. Brain Behav 2016; 6(12):e00586.
  • [27] Kotsis K, Voulgari PV, Tsifetaki N, Drosos AA, Carvalho AF, Hyphantis T. Illness perceptions and psychological distress associated with physical health-related quality of life in primary Sjögren’s syndrome compared to systemic lupus erythematosus and rheumatoid arthritis. Rheumatol Int 2014; 34(12):1671-81.
  • [28] Del Rosso A, Mikhaylova S, Baccini M, Lupi I, Matucci Cerinic M, Maddali Bongi S. In systemic sclerosis, anxiety and depression assessed by hospital anxiety depression scale are independently associated with disability and psychological factors. Biomed Res Int 2013; 2013:507493.
  • [29] March C, Huscher D, Preis E, Makowka A, Hoeppner J, Buttgereit F. Prevalence, risk factors and assessment of depressive symptoms in patients with systemic sclerosis. Arch Rheumatol 2019; 34(3):253-261.
  • [30] Nguyen C, Ranque B, Baubet T, Bérezné A, Mestre-Stanislas C, Rannou F. Clinical, functional and health-related quality of life correlates of clinically significant symptoms of anxiety and depression in patients with systemic sclerosis: a cross- sectional survey. PLoS One 2014; 9(2):e90484.
  • [31] Park EH, Strand V, Oh YJ, Song YW, Lee EB. Health-related quality of life in systemic sclerosis compared with other rheumatic diseases: a cross-sectional study. Arthritis Res Ther 2019; 21(1):61.

Yıl 2022, Cilt 12, Sayı 2, 285 - 293, 30.06.2022
https://doi.org/10.33808/clinexphealthsci.983685

Öz

Kaynakça

  • [1] Varan Ö, Babaoğlu H, Göker B. Associations between depressive disorders and inflammatory rheumatic diseases. Curr Top Med Chem 2018; 18(16):1395-1401.
  • [2] Lisitsyna TA, Veltishchev DY, Seravina OF, Kovalevskaya OB, Starovoytova MN, Desinova OV, et al. Comparative analysis of anxiety-depressive spectrum disorders in patients with rheumatic diseases. Ter Arkh 2018; 90(5):30-37.
  • [3] Gök K, Cengiz G, Erol K, Özgöçmen S. The Turkish version of multidimensional assessment of fatigue and fatigue severity scale is reproducible and correlated with other outcome measures in patients with systemic sclerosis. Arch Rheumatol 2016; 31(4):329-332.
  • [4] Grygiel-Górniak B, Limphaibool N, Puszczewicz M. Cytokine secretion and the risk of depression development in patients with connective tissue diseases. Psychiatry Clin Neurosci 2019; 73(6):302-316.
  • [5] Ware J, Snow K, Kosinski M, Gandek B. SF-36 health survey. Manual and interpretation guide. Boston, MA: New England Medical Center The Health Institute. 1993; 98(1-2):91-97.
  • [6] Aydemir O. Validity and reliability of Turkish version of hospital anxiety and depression scale. Turkish Journal of Psychiatry 1997; 8(4):280-287
  • [7] Tarakçı E, Arman N, Barut K, Şahin S, Adroviç A, Kasapçopur Ö. Fatigue and sleep in children and adolescents with juvenile idiopathic arthritis: a cross-sectional study. Turk J Med Sci 2019; 49(1):58-65.
  • [8] Kojima M, Kojima T, Waguri-Nagaya Y, Takahashi N, Asai S, Sobue Y. Depression, physical function, and disease activity associated with frailty in patients with rheumatoid arthritis. Mod Rheumatol 2021; 31(5):979-986
  • [9] Imran MY, Saira Khan EA, Ahmad NM, Farman Raja S, Saeed MA, Ijaz Haider I. Depression in rheumatoid arthritis and its relation to disease activity. Pak J Med Sci 2015; 31(2):393-7.
  • [10] Figueiredo-Braga M, Cornaby C, Cortez A, Bernardes M, Terroso G, Figueiredo M. Influence of biological therapeutics, cytokines, and disease activity on depression in rheumatoid arthritis. J Immunol Res 2018; 2018:5954897.
  • [11] Žagar I, Delimar V, Pap M, Perić D, Laktašić Žerjavić N, Perić P. Prevalence and correlation of depressive symptoms with functional scores, therapy and disease activity among Croatian patients with rheumatoid arthritis: a preliminary study. Psychiatr Danub 2018; 30 (4):452-458.
  • [12] Englbrecht M, Alten R, Aringer M, Baerwald CG, Burkhardt H, Eby N. New insights into the prevalence of depressive symptoms and depression in rheumatoid arthritis – Implications from the prospective multicenter VADERA II study. PLoS One 2019; 14(5):e0217412.
  • [13] Gök K, Erol K, Cengiz G, Özgöçmen S. Comparison of level of fatigue and disease correlates in patients with rheumatoid arthritis and systemic sclerosis. Arch Rheumatol. 2018; 33(3):316-321.
  • [14] Tay SH, Cheung PP, Mak A. Active disease is independently associated with more severe anxiety rather than depressive symptoms in patients with systemic lupus erythematosus. Lupus 2015; 2 4(13):1392-1399.
  • [15] Skinner-Taylor CM, Perez-Barbosa L, Corral-Trujillo ME, Perez- Onofre I, Barriga-Maldonado ES, Cardenas-de la Garza JA. Anxiety and depression in reproductive age women with rheumatic diseases. Rheumatol Int 2020; 40(9):1433-1438.
  • [16] Azizoddin DR, Gandhi N, Weinberg S, Sengupta M, Nicassio PM, Jolly M. Fatigue in systemic lupus: the role of disease activity and its correlates. Lupus. 2019; 28(2):163-173.
  • [17] Alsowaida N, Alrasheed M, Mayet A, Alsuwaida A, Omair MA. Medication adherence, depression, and disease activity among patients with systemic lupus erythematosus. Lupus 2018; 27(2):327-332
  • [18] Margiotta DPE, Fasano S, Basta F, Pierro L, Riccardi A, Navarini L. Clinical features of patients with systemic lupus erythematosus according to health-related quality of life, entity of pain, fatigue and depression: a cluster analysis. Clin Exp Rheumatol 2019; 37(4):535-539.
  • [19] Margiotta DPE, Fasano S, Basta F, Pierro L, Riccardi A, Navarini L. The association between duration of remission, fatigue, depression and health-related quality of life in Italian patients with systemic lupus erythematosus. Lupus 2019; 28(14):1705- 1711.
  • [20] Choi ST, Kang JI, Park IH, Lee YW, Song JS, Park YB. Subscale analysis of quality of life in patients with systemic lupus erythematosus: association with depression, fatigue, disease activity and damage. Clin Exp Rheumatol 2012; 30(5):665-72.
  • [21] Arnaud L, Mertz P, Amoura Z, Voll RE, Schwarting A, Maurier F. Patterns of fatigue and association with disease activity and clinical manifestations in systemic lupus erythematosus. Rheumatology (Oxford) 2020; 60(6):2672-2677
  • [22] Yilmaz-Oner S, Oner C, Dogukan FM, Moses TF, Demir K, Tekayev N. Anxiety and depression predict quality of life in Turkish patients with systemic lupus erythematosus. Clin Exp Rheumatol 2015; 33(3):360-5.
  • [23] Mok CC, Chan KL, Ho LY. Association of depressive/anxiety symptoms with quality of life and workability in patients with systemic lupus erythematosus. Clin Exp Rheumatol 2016; 34(3):389-95.
  • [24] Cui Y, Xia L, Li L, Zhao Q, Chen S, Gu Z. Anxiety and depression in primary Sjögren’s syndrome: a cross-sectional study. BMC Psychiatry 2018; 18(1):131.
  • [25] Milin M, Cornec D, Chastaing M, Griner V, Berrouiguet S, Nowak E, Marhadour T, Saraux A, Devauchelle-Pensec V. Sicca symptoms are associated with similar fatigue, anxiety, depression, and quality-of-life impairments in patients with and without primary Sjögren’s syndrome. Joint Bone Spine 2016; 83(6):681-685.
  • [26] Koçer B, Tezcan ME, Batur HZ, Haznedaroğlu Ş, Göker B, İrkeç C. Cognition, depression, fatigue, and quality of life in primary Sjögren’s syndrome: correlations. Brain Behav 2016; 6(12):e00586.
  • [27] Kotsis K, Voulgari PV, Tsifetaki N, Drosos AA, Carvalho AF, Hyphantis T. Illness perceptions and psychological distress associated with physical health-related quality of life in primary Sjögren’s syndrome compared to systemic lupus erythematosus and rheumatoid arthritis. Rheumatol Int 2014; 34(12):1671-81.
  • [28] Del Rosso A, Mikhaylova S, Baccini M, Lupi I, Matucci Cerinic M, Maddali Bongi S. In systemic sclerosis, anxiety and depression assessed by hospital anxiety depression scale are independently associated with disability and psychological factors. Biomed Res Int 2013; 2013:507493.
  • [29] March C, Huscher D, Preis E, Makowka A, Hoeppner J, Buttgereit F. Prevalence, risk factors and assessment of depressive symptoms in patients with systemic sclerosis. Arch Rheumatol 2019; 34(3):253-261.
  • [30] Nguyen C, Ranque B, Baubet T, Bérezné A, Mestre-Stanislas C, Rannou F. Clinical, functional and health-related quality of life correlates of clinically significant symptoms of anxiety and depression in patients with systemic sclerosis: a cross- sectional survey. PLoS One 2014; 9(2):e90484.
  • [31] Park EH, Strand V, Oh YJ, Song YW, Lee EB. Health-related quality of life in systemic sclerosis compared with other rheumatic diseases: a cross-sectional study. Arthritis Res Ther 2019; 21(1):61.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Bilimleri ve Hizmetleri
Bölüm Articles
Yazarlar

Dilek TEZCAN> (Sorumlu Yazar)
SELÇUK ÜNİVERSİTESİ, TIP FAKÜLTESİ
0000-0002-8295-9770
Türkiye


Semral GÜLCEMAL>
SELÇUK ÜNİVERSİTESİ, TIP FAKÜLTESİ
0000-0002-6085-9939
Türkiye


Muslu Kazım KÖREZ>
SELÇUK ÜNİVERSİTESİ, TIP FAKÜLTESİ
0000-0001-9524-6115
Türkiye


Sema YİLMAZ>
SELÇUK ÜNİVERSİTESİ, TIP FAKÜLTESİ
0000-0001-5076-1500
Türkiye

Yayımlanma Tarihi 30 Haziran 2022
Gönderilme Tarihi 17 Ağustos 2021
Kabul Tarihi 28 Ekim 2021
Yayınlandığı Sayı Yıl 2022, Cilt 12, Sayı 2

Kaynak Göster

Bibtex @araştırma makalesi { clinexphealthsci983685, journal = {Clinical and Experimental Health Sciences}, eissn = {2459-1459}, address = {}, publisher = {Marmara Üniversitesi}, year = {2022}, volume = {12}, number = {2}, pages = {285 - 293}, doi = {10.33808/clinexphealthsci.983685}, title = {Psychological Morbidity, Fatigue and Burden of Disease in Patients With Connective Tissue Diseases}, key = {cite}, author = {Tezcan, Dilek and Gülcemal, Semral and Körez, Muslu Kazım and Yilmaz, Sema} }
APA Tezcan, D. , Gülcemal, S. , Körez, M. K. & Yilmaz, S. (2022). Psychological Morbidity, Fatigue and Burden of Disease in Patients With Connective Tissue Diseases . Clinical and Experimental Health Sciences , 12 (2) , 285-293 . DOI: 10.33808/clinexphealthsci.983685
MLA Tezcan, D. , Gülcemal, S. , Körez, M. K. , Yilmaz, S. "Psychological Morbidity, Fatigue and Burden of Disease in Patients With Connective Tissue Diseases" . Clinical and Experimental Health Sciences 12 (2022 ): 285-293 <https://dergipark.org.tr/tr/pub/clinexphealthsci/issue/70757/983685>
Chicago Tezcan, D. , Gülcemal, S. , Körez, M. K. , Yilmaz, S. "Psychological Morbidity, Fatigue and Burden of Disease in Patients With Connective Tissue Diseases". Clinical and Experimental Health Sciences 12 (2022 ): 285-293
RIS TY - JOUR T1 - Psychological Morbidity, Fatigue and Burden of Disease in Patients With Connective Tissue Diseases AU - DilekTezcan, SemralGülcemal, Muslu KazımKörez, SemaYilmaz Y1 - 2022 PY - 2022 N1 - doi: 10.33808/clinexphealthsci.983685 DO - 10.33808/clinexphealthsci.983685 T2 - Clinical and Experimental Health Sciences JF - Journal JO - JOR SP - 285 EP - 293 VL - 12 IS - 2 SN - -2459-1459 M3 - doi: 10.33808/clinexphealthsci.983685 UR - https://doi.org/10.33808/clinexphealthsci.983685 Y2 - 2021 ER -
EndNote %0 Clinical and Experimental Health Sciences Psychological Morbidity, Fatigue and Burden of Disease in Patients With Connective Tissue Diseases %A Dilek Tezcan , Semral Gülcemal , Muslu Kazım Körez , Sema Yilmaz %T Psychological Morbidity, Fatigue and Burden of Disease in Patients With Connective Tissue Diseases %D 2022 %J Clinical and Experimental Health Sciences %P -2459-1459 %V 12 %N 2 %R doi: 10.33808/clinexphealthsci.983685 %U 10.33808/clinexphealthsci.983685
ISNAD Tezcan, Dilek , Gülcemal, Semral , Körez, Muslu Kazım , Yilmaz, Sema . "Psychological Morbidity, Fatigue and Burden of Disease in Patients With Connective Tissue Diseases". Clinical and Experimental Health Sciences 12 / 2 (Haziran 2022): 285-293 . https://doi.org/10.33808/clinexphealthsci.983685
AMA Tezcan D. , Gülcemal S. , Körez M. K. , Yilmaz S. Psychological Morbidity, Fatigue and Burden of Disease in Patients With Connective Tissue Diseases. Clinical and Experimental Health Sciences. 2022; 12(2): 285-293.
Vancouver Tezcan D. , Gülcemal S. , Körez M. K. , Yilmaz S. Psychological Morbidity, Fatigue and Burden of Disease in Patients With Connective Tissue Diseases. Clinical and Experimental Health Sciences. 2022; 12(2): 285-293.
IEEE D. Tezcan , S. Gülcemal , M. K. Körez ve S. Yilmaz , "Psychological Morbidity, Fatigue and Burden of Disease in Patients With Connective Tissue Diseases", Clinical and Experimental Health Sciences, c. 12, sayı. 2, ss. 285-293, Haz. 2022, doi:10.33808/clinexphealthsci.983685

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