Pharmacopoeia studies on Zingiber officinale Roscoe (ginger) samples purchased from a pharmacy and herbalists in İzmir and İstanbul

Year 2025, Volume: 15 Issue: 1, 117 - 123, 28.03.2025

Kasım Demir , Çağlayan Gürer

https://doi.org/10.33808/clinexphealthsci.1482709

Abstract

Objective: The aim of this study is to discover if the samples of Zingiber officinale were compatible with the criteria written in the European Pharmacopoeia, as quality control tests, which the analyses were done with the samples supplied from a pharmacy and the herbal stores. Also gathering knowledge from the scientifical literature of the drug’s activities a contribution was made to the phytotherapy.
Methods: One pharmacy and five herbalist samples were examined and the quality control tests were done due to the monograph in the European Pharmacopoeia. According to the monograph macroscopic and microscopic assays, thin layer chromatography with methanolic extract, loss on drying, total ash and essential oil determination assays accomplished.
Results: With the macroscopic analysis and the microscopic analysis, the pharmacy sample were compatible with the criteria stated in Pharmacopoeia but one sample from herbal store had some unwanted and unidentified particles. The results of the loss on drying test which is repeated three times for each sample showed that the pharmacy sample and one from herbal store has more moisture than stated in the Pharmacopoeia. Also, total ash determination test was done three times and found that all the samples met the criteria stated in the Pharmacopoeia 7.0.
Conclusion: The results of the essential oil determination tests showed us that the sample obtained from pharmacy and three of the herbal stores were meeting the criteria but the EO’s of the other samples were under the amount stated in the Pharmacopoeia.

Keywords

Antioxidant, European Pharmacopoeia, Zingiber officinale Roscoe, Zingiberis rhizoma

Ethical Statement

Since this article does not contain any study containing human or animal subjects, ethical approval is not applicable.

Supporting Institution

Istanbul University Research Project Unit (BAPSIS)

Project Number

23383

References

• Jansen PCM. Species, condiments and medicinal plants in Ethiopia, their taxonomy and agricultural significance. Wageningen: Centre for Agricultural Publishing and Documentation; 1981.
• Caldwell RA. Comparative Grammer of Dravidian or South Indian Family of Languages (3rd ed.). Madras: Asian Educational Services; 1998.
• ESCOP. Zingiberis rhizoma the scientific foundation for herbal medicinal products. European Scientific Cooperative on Phytotherapy (2th ed.). New York; 2003.
• Rahmani AH, Al Shabrmi FM, Aly SM. Review article: Active ingredients of Ginger as potential candidates in the prevention and treatment of diseases via modulation of biological activities. International Journal of Physiology Pathophysiology and Pharmacology 2014; 6: 125-136.
• Aly UI, Abbas MS, Taha HS, Gaber ESI. Characterization of 6-Gingerol for in-vivo and in-vitro Ginger (Zingiber officinale) using high performance liquid chromatography. Global Journal of Botanical Science 2013; 1: 9-17. https://doi.org/10.12974/2311-858X.2013.01.01.2
• Morakinyo AO, Achema PU, Adegoke OA. Effect of Zingiber officinale (Ginger) on sodium arsenite-induced reproductive toxicity in male rats. African Journal of Biomedical Research 2010; 13: 39–45.
• Blumenthal M, Busse WR, Goldberg A, Gruenwald J, Hall T, Riggins CW, Rister RS. The Complete German Commission E Monographs. Therapeutic Guide to Herbal Medicines. American Botanical Council. Austin; 1998.
• Çubukçu B, Meriçli AH, Sarıyar G, Mat A, Sütlüpınar N, Meriçli F. Fitoterapi Yardımcı Ders Kitabı. İstanbul: İstanbul Üniveristesi Basım ve Yayınevi; 2002.(Turkish)
• Shakya SB. Medicinal uses of Ginger (Zingiber officinale Roscoe) improves growth and enhances immunity in aquaculture. International Journal of Chemical Studies 2015; 3(2): 83-87.
• Qin F, Xu H-L. High-performance liquid chromatography–electrospray mass spectrometric analysis of pungent constituents of Ginger. Medicinal and Aromatic Plant Science and Biotechnology 2008; 2(29): 72-78. https://doi.org/10.1016/S0021-9673(97)01013-3
• McKay DL, Chen CY, Zampariello CA, Blumberg JB. Flavonoids and phenolic acids from cranberry juice are bioavailable and bioacitve in healthy older adults. Food Chemistry 2015; 168: 233-240. https://doi.org/10.1016/j.foodchem.2014.07.062
• Ojewole JAO. Analgesic, antiinflammatory and hypoglicaemic effects of ethanol extract of Zingiber officinale (Roscoe) rhizomes (Zingiberaceae) in mice and rats. Phytotherapy Research 2006; 20: 764-772. https://doi.org/10.1002/ptr.1952
• Narasimhan S, Govindarajan VS. Evalution of spices and oleoresin: VI. Pungency of the ginger components gingerol and shogaol and their quality. Journal of Food Technology 1978; 13: 31-36. https://doi.org/10.1111/j.1365-2621.1978.tb00773.x
• Chrubasik S, Pittler MH, Roufogalis BD. Zingiberis rhizoma: A comprehensive review on the Ginger effect and efficacy profiles. Phytomedicine 2005; 12: 684-701. https://doi.org/10.1016/j.phymed.2004.07.009
• Young H-Y, Liao J-C, Chang Y-S, Luo Y-L, Lu M-C, Peng W-H. Synergistic effect of Ginger and Nifedipine on human platelet aggregation: A study in hypertensive patients and normal volunteers. The American Journal of Chinese Medicine 2006; 34(4): 545–551. https://doi.org/10.1142/S0192415X06004089
• Jeena K, Liju VB, Kuttan R. A preliminary 13-week oral toxicity study of Ginger oil in male and female wistar rats. International Journal of Toxicology 2011; 30(6): 662-670. https://doi.org/10.1177/1091581811419023
• Ladipo MK, Doherty VF, Kanife UC. Heavy metal analysis and phytochemical screening of two indigenous species (Zingiber officinale and Centrosema Pubescens) from Nigeria. International Journal of Current Research 2011; 33(4): 95-99.
• Kemper JK. Ginger. Longwood Herbal Task Force, Rev: 09.11, 2; 1999.
• Ghayur MN, Gilani AH, Mehmood MH, Aziz N. Pharmacological basis for the medicinal use of ginger in gastrointestinal disorders. Digestive Diseases Sciences 2005; 50(10): 1889-1897. https://doi.org/10.1007/s10620-005-2957-2
• Oluwatoyin A. Physicochemical characterisation, and antioxidant properties of the seeds and oils of Ginger (Zingiber officinale) and Garlic (Allium sativum). Science Journal of Chemistry 2014; 2(6): 44-50. https://doi.org/10.11648/j.sjc.20140206.11
• Al-Kushi AG, El-Boshy ME, ElSawy NA, Omar OAS, Header EA. Pathological comparative studies on aqueous and ethanolic extracts of Zingiber officinale on antioxidants and hypolipidemic effects in rats. Life Science Journal 2013; 10(2): 2393-2403.
• Sakr SA, Shalaby SY. Ginger extract protects metalaxyl-induced histomorphological and histochemical alterations in testes of albino mice. Journal of Applied Pharmaceutical Science 2011; 1(10): 36-42.
• Ramadan MM, El-Shershaby EM, Ismail MF, Farag SAM. The protective effect of Ginger on ovotoxicity induced by 7,12-Dimethylbenz[A]Anthracene (DMBA) in rat. Egyptian Journal of Experimental Biology (Zoology) 2009; 5: 227 – 233. https://doi.org/10.12816/0027817
• Ensiyeh J, Sakineh MA.Comparing Ginger and vitamin B6 for the treatment of nausea and vomiting in pregnancy: a randomised controlled trial Midwifery 2009; 25: 649–653. https://doi.org/10.1016/j.midw.2007.10.013
• Pongrojpaw D, Somprasit C, Chanthasenanont A. A randomized comparison of Ginger and dimenhydrinate in the treatment of nausea and vomiting in pregnancy. Journal of the Medical Association of Thailand 2007; 90(9): 1703-1709.
• Abascal K, Yarnell E. Clinical uses of Zingiber officinale (Ginger). Alternative and complementary therapies 2009; 15(5): 231-237. https://doi.org/10.1089/act.2009.15501
• Phillips S, Ruggier R, Hutchinson SE. Zingiber officinale (Ginger)-an antiemetic for day case surgery. Anaesthesia 1993; 48: 715-717. https://doi.org/10.1111/j.1365-2044.1993.tb07188.x
• Bone ME, Wilkinson DJ, Young JR, McNeil J, Charlton S. Ginger root-a new antiemetic. The effect of Ginger root on postoperative nausea and vomiting after major gynaecological surgery. Anaesthesia 1990; 45: 669-671. https://doi.org/10.1111/j.1365-2044.1990.tb14395.x
• Kapalka GM. Nutritional and Herbal Therapies for Children and Adolescents: A Handbook for Mental Health Clinicians. Londra. Academic Press. 2010; 250. https://doi.org/10.1016/C2009-0-01890-X
• Van Toorenenbergen AW, Dieges PH. Immunoglobulin-E antibodies against coriander and other spices. Journal of Allergy and Clinical Immunology 1985; 76: 477–481. https://doi.org/10.1016/0091-6749(85)90730-4
• Desai HG, Kalro RH, Choksi AP. Effect of ginger & garlic on DNA content of gastric aspirate. Indian Journal of Medicinal Research. 1990; 92: 139–141.
• Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. (4th ed.). Florence: Thompson Healthcare Library Products. 2007.