BIOLOGICAL ACTIVITIES OF ADIANTUM CAPILLUS-VENERIS COLLECTED FROM DUHOK PROVINCE (IRAQ)

Abstract

           This study determined the DPPH free-radical scavenging activity, total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI), DNA-protective activity, antiproliferative activity, antimicrobial activity and phenolic contents of methanol (MeOH) and dichloromethane (DCM) extracts of A. capillus-veneris leaves collected from the province of Duhok (Iraq). As a result of the studies, it was determined that the MeOH extract of A. calocephalum had a 49.74% free-radical scavenging activity at 2 mg/mL concentration. It was found that the extracts were effective against the test microorganisms at a concentration level of 200-400 µg/mL. TAS, TOS and OSI values were 3.086±0.066, 21.532±0.525 and 0.698±0.002, respectively. The DNA-protective activity of the extracts was found to be weak compared to the positive control. It was found that, depending on the increase in concentration, the extracts showed antiproliferative activity on A549 cells. Furthermore, the HPLC analyses found Catechin, Cinnamic acid, Chlorogenic acid, Caffeic acid, p-Coumaric acid, Rosmarinic acid and 4-Hydroxybenzoic acid with various ppm values. Consequently, it was determined that A. capillus-veneris could be a potential natural source pharmacologically.

Keywords

• Adiantum capillus-veneris,Antioxidant,Antimicrobial,DNA protective,antiproliferative,Phenolic content

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