Araştırma Makalesi
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Yıl 2019, Cilt: 28 Sayı: 1, 101 - 113, 30.06.2019

Öz

Kaynakça

  • N. H. Cho, J. E. Shaw, S. Karuranga, Y. Huang, J. D. Da Rocha Fernandes, A. W. Ohlrogge, et al., IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045, Diabetes Research and Clinical Practice, 138, (2018) 271-281.
  • R. N. Jangir, G. C. Jain, Diabetes mellitus induced impairment of male reproductive functions: a review, Current Diabetes Reviews, 10 (3), (2014) 147-157.
  • M. W. Mcdonald, M. R. Murray, K. N. Grise, T. D. Olver, A. Dey, J. K. Shoemaker, et al., The glucoregulatory response to high-intensity aerobic exercise following training in rats with insulin-treated type 1 diabetes mellitus, Applied Physiology Nutrition and Metabolism, 41 (6), (2016) 631-639.
  • H. Shoorei, A. Khaki, A. A. Khaki, A. A. Hemmati, M. Moghimian, M. Shokoohi, The ameliorative effect of carvacrol on oxidative stress and germ cell apoptosis in testicular tissue of adult diabetic rats, Biomedicine Pharmacotherapy, 111, (2018) 568-578.
  • J. L. Leahy, Pathogenesis of type 2 diabetes mellitus, Archives of Medical Research, 36 (3), (2005) 197-209.
  • A. P. Sinha Hikim, R. S. Swerdloff, Hormonal and genetic control of germ cell apoptosis in the testis, Reviews of Reproduction, 4 (1), (1999) 38-47.
  • J. C. Hutson, D. M. Stocco, G. T. Campbell, J. Wagoner, Sertoli cell function in diabetic, insulin-treated diabetic, and semi-starved rats, Diabetes, 32 (2), (1983) 112-116.
  • N. M. Grebe, R. E. Sarafin, C. R. Strenth, S. Zilioli, Pair-bonding, fatherhood, and the role of testosterone: A meta-analytic review, Neuroscience Biobehavioral Reviews, 98, (2019) 221-233.
  • [L. Gnessi, F. Scarselli, M. G. Minasi, S. Mariani, C. Lubrano, S. Basciani, et al., Testicular histopathology, semen analysis and FSH, predictive value of sperm retrieval: supportive counseling in case of reoperation after testicular sperm extraction (TESE), BMC Urology, 18 (1), (2018) 63.
  • G. Boner, Management of diabetic nephropathy: epidemiology, pathogenesis of nephropathy and factors influencing progression, Edtna Erca Journal, 30 (3), (2004) 131-134.
  • F. T. Murray, D. F. Cameron, J. M. Orth, Gonadal dysfunction in the spontaneously diabetic BB rat, Metabolism, 32 (7), (1983), 141-147.
  • R. E. Sanguinetti, K. Ogawa, M. Kurohmaru, Y. Hayashi, Ultrastructural changes in mouse Leydig cells after streptozotocin administration, Experimental Animals, 44 (1), (1995) 71-73.
  • V. H. Cagnon, A. M. Camargo, R. M. Rosa, R. Fabiani, C. R. Padovani, F. E. Martinez, Ultrastructural study of the ventral lobe of the prostate of mice with streptozotocin induced diabetes (C57BL/6J), Tissue and Cell, 32 (4), (2000) 275-283.
  • L. B. Bondarenko, G. M. Shayakhmetova, A. V. Matvienko, V. M. Kovalenko, Diabetes-mediated changes in rat type I collagen and spermatogenesis indices, Romanian Journal of Diabetes Nutrition, 19 (3), (2012) 245-254.
  • D. Kianifard, R. A. Sadrkhanlou, S. Hasanzadeh, The ultrastructural changes of the sertoli and leydig cells following streptozotocin induced diabetes, Iranian journal of basic medical sciences, 15 (1), (2012) 623.
  • P. O. Koh, Streptozotocin-Induced Diabetes Increases Apoptotic Cell Death in Rat Epididymis, Laboratory Animal Research, 23 (4), (2007) 381-384.
  • M. Mohasseb, S. Ebied, M. A. Yehia, N. Hussein, Testicular oxidative damage and role of combined antioxidant supplementation in experimental diabetic rats, Journal of Physiology and Biochemistry, 67 (2), (2011) 185-194.
  • J. R. Wright, A. J. Yates, H. M. Sharma, C. Shim, R. L. Tigner, P. Thibert, Testicular atrophy in the spontaneously diabetic BB Wistar rat, The American Journal of Pathology, 108 (1), (1982) 72-79.
  • J. E. Anderson, J. A. Thliveris, Testicular histology in streptozotocin-induced diabetes, The Anatomical Record, 214 (4), (1986) 378-382.
  • L. Cai, S. Chen, T. Evans, D. X. Deng, K. Mukherjee, S. Chakrabarti, Apoptotic germ-cell death and testicular damage in experimental diabetes: prevention by endothelin antagonism, Urological Research, 28 (5), (2000) 342-347.
  • B. Altay, S. Cetinkalp, B. Doganavsargil, M. Hekimgil, B. Semerci, Streptozotocin-induced diabetic effects on spermatogenesis with proliferative cell nuclear antigen immunostaining of adult rat testis, Fertility and Sterility, 80 (2), (2003) 828-831.
  • D. F. Cameron, F. T. Murray, D. D. Drylie, Interstitial compartment pathology and spermatogenic disruption in testes from impotent diabetic men, The Anatomical Record, 213 (1), (1985) 53-62.
  • F. Öztürk, M. Gül, M. Ağkadir, M. Yağmurca, Deneysel Diyabetin Sıçan Testislerinde Meydana Getirdiği Histolojik Değişiklikler, Turkiye Klinikleri Journal of Medical Sciences, 22 (2), (2002) 173-178.
  • J. Perez Diaz, A. Benitez, C. Fernandez Galaz, Effect of streptozotocin diabetes on the pituitary-testicular axis in the rat, Hormone and Metabolic Research, 14 (9), (1982) 479-482.
  • R. W. Steger, Testosterone replacement fails to reverse the adverse effects of streptozotocin-induced diabetes on sexual behavior in the male rat, Pharmacology Biochemistry and Behavior, 35 (3), (1990) 577-582.
  • M. Kaya, Sertoli cells and various types of multinucleates in the rat seminiferous tubules following temporary ligation of the testicular artery, Journal of Anatomy, 144, (1986) 15.
  • M. D. Leon, V. A. Chiauzzi, J. C. Calvo, E. H. Charreau, H. E. Chemes, Acute hCG administration induces seminiferous tubule damage in the adult rat, Acta Physiologica Pharmacologica et therapeutica latinoamericana, 37 (2), (1987) 277-288.
  • D. Cernochova, V. Kamarad, Toxic effect of lead of mice testicles after its administration with drinking water, Acta Universitatis Palackianae Olomucensis Facultatis Medicae, 133, (1992) 9-13.
  • H. M. Torgersen, E. Rovan, M. Steiner, J. Frick, H. Adam, BCG-induced orchitis: structural changes during the degeneration of seminiferous tubules of rats and rabbits, Urological Research, 10 (2), (1982) 97-104.
  • I. Sasagawa, T. Nakada, Y. Kubota, M. Ishigooka, K. Uchida, K. Doi, In vivo 31P magnetic resonance spectroscopy for evaluation of testicular function in cryptorchid rats, Journal of Urology, 154 (4), (1995) 1557-1559.
  • B. Fox, Oxford textbook of pathology, 305, (1992) 658-659.
  • J. Ballester, M. C. Munoz, J. Dominguez, T. Rigau, J. J. Guinovart, J. E. Rodriguez-Gil, Insulin-dependent diabetes affects testicular function by FSH- and LH-linked mechanisms, Journal of Andrology, 25 (5), (2004) 706-719.
  • J. E. Anderson, J. A. Thliveris, Morphometry and cytochemistry of Leydig cells in experimental diabetes, The American journal of anatomy, 180 (1), (1987) 41-48.

HISTOMORPHOLOGICAL CHANGES ON THE TESTICULAR TISSUE IN DIABETIC RATS INDUCED WITH STREPTOZOTOCIN

Yıl 2019, Cilt: 28 Sayı: 1, 101 - 113, 30.06.2019

Öz

Diabetes Mellitus (DM) is a chronic metabolic disease characterized with various complications due to its damage on many organs. One of the most common complications of DM is testicular damage. Therefore, it is necessary to start a treatment agent promptly during this process which may lead to infertility. There are treatment steps that seriously prolong the process of complications of this dangerous disease. However, there are some contradictions in numerous studies conducted regarding which agent the treatment should continue with according to the stage of the diabetes in the patient. In this context, examining the functions of male reproductive system may prevent these contradictions in the future.  In this study, 2 groups were used; one of them consisted of the healthy rats and the other consisted of the ones that became diabetes by induction of streptozotocin. The animals of both groups were fed under the same sheltering conditions and testicle tissues of both groups were evaluated under light microscope. As a result of histomorphological examination of testicular tissues, the pathologies such as impaired integrity of the seminiferous tubules especially in the testicles of diabetic rats, the separation of germinal epithelium cells from connective tissue and from each other and the presence of prominent necrosis focuses in spermatogenic cells were found to be noteworthy. In this study, it has been evaluated that cellular pathological changes are clearly revealed under the microscope. It is believed that the results of the study will contribute to the clinical studies regarding the treatment and may shed light on research at molecular level.

Kaynakça

  • N. H. Cho, J. E. Shaw, S. Karuranga, Y. Huang, J. D. Da Rocha Fernandes, A. W. Ohlrogge, et al., IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045, Diabetes Research and Clinical Practice, 138, (2018) 271-281.
  • R. N. Jangir, G. C. Jain, Diabetes mellitus induced impairment of male reproductive functions: a review, Current Diabetes Reviews, 10 (3), (2014) 147-157.
  • M. W. Mcdonald, M. R. Murray, K. N. Grise, T. D. Olver, A. Dey, J. K. Shoemaker, et al., The glucoregulatory response to high-intensity aerobic exercise following training in rats with insulin-treated type 1 diabetes mellitus, Applied Physiology Nutrition and Metabolism, 41 (6), (2016) 631-639.
  • H. Shoorei, A. Khaki, A. A. Khaki, A. A. Hemmati, M. Moghimian, M. Shokoohi, The ameliorative effect of carvacrol on oxidative stress and germ cell apoptosis in testicular tissue of adult diabetic rats, Biomedicine Pharmacotherapy, 111, (2018) 568-578.
  • J. L. Leahy, Pathogenesis of type 2 diabetes mellitus, Archives of Medical Research, 36 (3), (2005) 197-209.
  • A. P. Sinha Hikim, R. S. Swerdloff, Hormonal and genetic control of germ cell apoptosis in the testis, Reviews of Reproduction, 4 (1), (1999) 38-47.
  • J. C. Hutson, D. M. Stocco, G. T. Campbell, J. Wagoner, Sertoli cell function in diabetic, insulin-treated diabetic, and semi-starved rats, Diabetes, 32 (2), (1983) 112-116.
  • N. M. Grebe, R. E. Sarafin, C. R. Strenth, S. Zilioli, Pair-bonding, fatherhood, and the role of testosterone: A meta-analytic review, Neuroscience Biobehavioral Reviews, 98, (2019) 221-233.
  • [L. Gnessi, F. Scarselli, M. G. Minasi, S. Mariani, C. Lubrano, S. Basciani, et al., Testicular histopathology, semen analysis and FSH, predictive value of sperm retrieval: supportive counseling in case of reoperation after testicular sperm extraction (TESE), BMC Urology, 18 (1), (2018) 63.
  • G. Boner, Management of diabetic nephropathy: epidemiology, pathogenesis of nephropathy and factors influencing progression, Edtna Erca Journal, 30 (3), (2004) 131-134.
  • F. T. Murray, D. F. Cameron, J. M. Orth, Gonadal dysfunction in the spontaneously diabetic BB rat, Metabolism, 32 (7), (1983), 141-147.
  • R. E. Sanguinetti, K. Ogawa, M. Kurohmaru, Y. Hayashi, Ultrastructural changes in mouse Leydig cells after streptozotocin administration, Experimental Animals, 44 (1), (1995) 71-73.
  • V. H. Cagnon, A. M. Camargo, R. M. Rosa, R. Fabiani, C. R. Padovani, F. E. Martinez, Ultrastructural study of the ventral lobe of the prostate of mice with streptozotocin induced diabetes (C57BL/6J), Tissue and Cell, 32 (4), (2000) 275-283.
  • L. B. Bondarenko, G. M. Shayakhmetova, A. V. Matvienko, V. M. Kovalenko, Diabetes-mediated changes in rat type I collagen and spermatogenesis indices, Romanian Journal of Diabetes Nutrition, 19 (3), (2012) 245-254.
  • D. Kianifard, R. A. Sadrkhanlou, S. Hasanzadeh, The ultrastructural changes of the sertoli and leydig cells following streptozotocin induced diabetes, Iranian journal of basic medical sciences, 15 (1), (2012) 623.
  • P. O. Koh, Streptozotocin-Induced Diabetes Increases Apoptotic Cell Death in Rat Epididymis, Laboratory Animal Research, 23 (4), (2007) 381-384.
  • M. Mohasseb, S. Ebied, M. A. Yehia, N. Hussein, Testicular oxidative damage and role of combined antioxidant supplementation in experimental diabetic rats, Journal of Physiology and Biochemistry, 67 (2), (2011) 185-194.
  • J. R. Wright, A. J. Yates, H. M. Sharma, C. Shim, R. L. Tigner, P. Thibert, Testicular atrophy in the spontaneously diabetic BB Wistar rat, The American Journal of Pathology, 108 (1), (1982) 72-79.
  • J. E. Anderson, J. A. Thliveris, Testicular histology in streptozotocin-induced diabetes, The Anatomical Record, 214 (4), (1986) 378-382.
  • L. Cai, S. Chen, T. Evans, D. X. Deng, K. Mukherjee, S. Chakrabarti, Apoptotic germ-cell death and testicular damage in experimental diabetes: prevention by endothelin antagonism, Urological Research, 28 (5), (2000) 342-347.
  • B. Altay, S. Cetinkalp, B. Doganavsargil, M. Hekimgil, B. Semerci, Streptozotocin-induced diabetic effects on spermatogenesis with proliferative cell nuclear antigen immunostaining of adult rat testis, Fertility and Sterility, 80 (2), (2003) 828-831.
  • D. F. Cameron, F. T. Murray, D. D. Drylie, Interstitial compartment pathology and spermatogenic disruption in testes from impotent diabetic men, The Anatomical Record, 213 (1), (1985) 53-62.
  • F. Öztürk, M. Gül, M. Ağkadir, M. Yağmurca, Deneysel Diyabetin Sıçan Testislerinde Meydana Getirdiği Histolojik Değişiklikler, Turkiye Klinikleri Journal of Medical Sciences, 22 (2), (2002) 173-178.
  • J. Perez Diaz, A. Benitez, C. Fernandez Galaz, Effect of streptozotocin diabetes on the pituitary-testicular axis in the rat, Hormone and Metabolic Research, 14 (9), (1982) 479-482.
  • R. W. Steger, Testosterone replacement fails to reverse the adverse effects of streptozotocin-induced diabetes on sexual behavior in the male rat, Pharmacology Biochemistry and Behavior, 35 (3), (1990) 577-582.
  • M. Kaya, Sertoli cells and various types of multinucleates in the rat seminiferous tubules following temporary ligation of the testicular artery, Journal of Anatomy, 144, (1986) 15.
  • M. D. Leon, V. A. Chiauzzi, J. C. Calvo, E. H. Charreau, H. E. Chemes, Acute hCG administration induces seminiferous tubule damage in the adult rat, Acta Physiologica Pharmacologica et therapeutica latinoamericana, 37 (2), (1987) 277-288.
  • D. Cernochova, V. Kamarad, Toxic effect of lead of mice testicles after its administration with drinking water, Acta Universitatis Palackianae Olomucensis Facultatis Medicae, 133, (1992) 9-13.
  • H. M. Torgersen, E. Rovan, M. Steiner, J. Frick, H. Adam, BCG-induced orchitis: structural changes during the degeneration of seminiferous tubules of rats and rabbits, Urological Research, 10 (2), (1982) 97-104.
  • I. Sasagawa, T. Nakada, Y. Kubota, M. Ishigooka, K. Uchida, K. Doi, In vivo 31P magnetic resonance spectroscopy for evaluation of testicular function in cryptorchid rats, Journal of Urology, 154 (4), (1995) 1557-1559.
  • B. Fox, Oxford textbook of pathology, 305, (1992) 658-659.
  • J. Ballester, M. C. Munoz, J. Dominguez, T. Rigau, J. J. Guinovart, J. E. Rodriguez-Gil, Insulin-dependent diabetes affects testicular function by FSH- and LH-linked mechanisms, Journal of Andrology, 25 (5), (2004) 706-719.
  • J. E. Anderson, J. A. Thliveris, Morphometry and cytochemistry of Leydig cells in experimental diabetes, The American journal of anatomy, 180 (1), (1987) 41-48.
Toplam 33 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Yapısal Biyoloji
Bölüm Review Articles
Yazarlar

Nihal Saçmaozu Bu kişi benim 0000-0003-4646-7194

Hatice Mutlu Eyıson Bu kişi benim 0000-0002-4637-5268

Suna Cebesoy 0000-0001-7484-2882

Yayımlanma Tarihi 30 Haziran 2019
Kabul Tarihi 18 Haziran 2019
Yayımlandığı Sayı Yıl 2019 Cilt: 28 Sayı: 1

Kaynak Göster

Communications Faculty of Sciences University of Ankara Series C-Biology.

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This work is licensed under a Creative Commons Attribution 4.0 International License.