In vitro Evaluation of Antigenotoxic Effects of Phloridzin

Mehmet Sarimahmut; Sindi Vekshari; Merve Demirbag Karaali; Serap Celikler

doi:10.17776/csj.1035449

EN

In vitro Evaluation of Antigenotoxic Effects of Phloridzin

Abstract

Phytochemicals have a vast number of properties contributing to human health by acting on numerous different mechanisms. Phloridzin, a phytochemical mainly found in Malus species, possesses diverse biological activities including anti-diabetic and antioxidative activities. Here, our aim is to explore antigenotoxic potential and proliferative effects of phloridzin on human lymphocytes in vitro by employing chromosome aberration, micronucleus and comet assays. Mitomycin C, both an anticancer and genotoxic agent, was utilized to induce genotoxicity. Phloridzin significantly suppressed the genotoxic effects of mitomycin C at 125-500 µg/mL concentrations in all assays used (p < 0.05). We also revealed that phloridzin and mitomycin C combination had a significantly negative effect on mitotic index (p < 0.05), whereas in general, gender differences did not play a role in manifestation of neither antigenotoxic nor antiproliferative activities of the combination.These results suggest that phloridzin is an antigenotoxic compound and its consumption may interfere with the activity of anticancer drugs that exert their effects based on genotoxic mechanisms.

Keywords

Phlorizin, Genotoxicity, Mitomycin C, Chromosome aberration.

Thanks

The authors would like to thank Ahmet Sari Mahmout for English editing and proofreading of the manuscript.

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Details

Primary Language

English

Subjects

Structural Biology

Journal Section

Research Article

Authors

Mehmet Sarimahmut ^*
0000-0003-2647-5875
Türkiye

Sindi Vekshari This is me
0000-0001-7975-3950
Türkiye

Merve Demirbag Karaali This is me
0000-0002-2874-0241
Türkiye

Serap Celikler This is me
0000-0002-4177-3478
Türkiye

Publication Date

September 30, 2022

Submission Date

December 14, 2021

Acceptance Date

August 27, 2022

Published in Issue

Year 2022 Volume: 43 Number: 3

DOI

https://doi.org/10.17776/csj.1035449

IZ

https://izlik.org/JA28DC83UZ

APA

Sarimahmut, M., Vekshari, S., Demirbag Karaali, M., & Celikler, S. (2022). In vitro Evaluation of Antigenotoxic Effects of Phloridzin. Cumhuriyet Science Journal, 43(3), 358-364. https://doi.org/10.17776/csj.1035449

AMA

1.Sarimahmut M, Vekshari S, Demirbag Karaali M, Celikler S. In vitro Evaluation of Antigenotoxic Effects of Phloridzin. CSJ. 2022;43(3):358-364. doi:10.17776/csj.1035449

Chicago

Sarimahmut, Mehmet, Sindi Vekshari, Merve Demirbag Karaali, and Serap Celikler. 2022. “In Vitro Evaluation of Antigenotoxic Effects of Phloridzin”. Cumhuriyet Science Journal 43 (3): 358-64. https://doi.org/10.17776/csj.1035449.

EndNote

Sarimahmut M, Vekshari S, Demirbag Karaali M, Celikler S (September 1, 2022) In vitro Evaluation of Antigenotoxic Effects of Phloridzin. Cumhuriyet Science Journal 43 3 358–364.

IEEE

[1]M. Sarimahmut, S. Vekshari, M. Demirbag Karaali, and S. Celikler, “In vitro Evaluation of Antigenotoxic Effects of Phloridzin”, CSJ, vol. 43, no. 3, pp. 358–364, Sept. 2022, doi: 10.17776/csj.1035449.

ISNAD

Sarimahmut, Mehmet - Vekshari, Sindi - Demirbag Karaali, Merve - Celikler, Serap. “In Vitro Evaluation of Antigenotoxic Effects of Phloridzin”. Cumhuriyet Science Journal 43/3 (September 1, 2022): 358-364. https://doi.org/10.17776/csj.1035449.

JAMA

1.Sarimahmut M, Vekshari S, Demirbag Karaali M, Celikler S. In vitro Evaluation of Antigenotoxic Effects of Phloridzin. CSJ. 2022;43:358–364.

MLA

Sarimahmut, Mehmet, et al. “In Vitro Evaluation of Antigenotoxic Effects of Phloridzin”. Cumhuriyet Science Journal, vol. 43, no. 3, Sept. 2022, pp. 358-64, doi:10.17776/csj.1035449.

Vancouver

1.Mehmet Sarimahmut, Sindi Vekshari, Merve Demirbag Karaali, Serap Celikler. In vitro Evaluation of Antigenotoxic Effects of Phloridzin. CSJ. 2022 Sep. 1;43(3):358-64. doi:10.17776/csj.1035449

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