Protective Role of Resveratrol Against Toluene-Induced Oxidative Stress in Rats
Abstract
Toluene is a toxic substance commonly used in the industry that leads to oxidative stress in the body and causes in the formation of reactive oxygen species. In addition to the antioxidants produced by our body, we also obtain antioxidants through foods. Resveratrol is a polyphenol found in many plant species and possesses antioxidant properties. The effects of oxidative stress induced by toluene and the protective effect of resveratrol were investigated through changes in malondialdehyde (MDA) and glutathione (GSH) levels. Male rats were administered different doses of toluene and resveratrol (5 mg/kg, 10 mg/kg, 20 mg/kg), while control groups were given physiological saline and ethanol. At the end of the experiment, blood and lung tissues of the animals were examined, and MDA and GSH levels were measured. According to the obtained data, a significant increase in GSH activity was observed after the administration of toluene. However, in groups treated with combinations of toluene and various doses of resveratrol, a significant decrease in GSH levels was detected. While a significant increase in MDA levels in lung tissues was observed between the control groups and the toluene group, no significant change was observed in blood samples.
Keywords
Toluene, Resveratrol, Malondialdehyde, Glutathione
Supporting Institution
Bursa Uludağ Üniversitesi Bilimsel Araştırmalar Birimi
Project Number
QUAP(F)-2019/14.
Ethical Statement
Bu çalışma Bursa Uludağ Üniversitesi Bilimsel Araştırma Projeleri Birimi tarafından desteklenmiştir (QUAP(F)-2019/14). Deneyler, hayvan deneyleri yerel etik kurulundan alınan 2019/04-03 numaralı etik kurul kararına uygun olarak ve 2013 yılında revize edilen Helsinki Deklarasyonuna uyularak gerçekleştirilmiştir
Thanks
Makale, Uludağ Üniversitesi Fen Bilimleri Enstitüsü, Biyoloji Anabilim Dalı, Moleküler Biyoloji Bilim Dalında Ahmad Baratov tarafından tamamlanan "Resveratrolün Toluen Maruziyetine Bağlı Oksidatif Stres Etkilerine Karşı Koruyucu Özelliklerinin Araştırılması" başlıklı yüksek lisans tezine dayanmaktadır. Bu çalışmaya katkılarından dolayı Emine Gonca PEKEL, Oğuzhan Akgün ve Raissa SOAMANJARY'ye teşekkür ederiz.
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