Investigation of Biological Activity of Squamarina cartilaginea (With.) P. James Species Distributed in Türkiye

Banu Ceren Değirmenci; Mustafa Kocakaya; Selen İlgün; Gökçe Şeker Karatoprak; Zekiye Kocakaya; Ahmet Ceylan

doi:10.17776/csj.1424202

EN

Investigation of Biological Activity of Squamarina cartilaginea (With.) P. James Species Distributed in Türkiye

Abstract

In this study, the methanol extract of Squamarina cartilaginea, a species distributed in Türkiye, was investigated for its antimicrobial, antioxidant, cytotoxic, and DNA protective effects. The chemical composition of the extract was elucidated through spectroscopic determination of total phenols, total flavonoids, and chromatographic quantification of usnic acid. Antimicrobial activity was assessed using the disk diffusion method, revealing a significant zone of inhibition with a diameter of 17.5 mm against M. luteus and S. aureus. The antioxidant activity was evaluated through scavenging activities against DPPH and ABTS radicals, demonstrating a concentration-dependent potent scavenging activity against ABTS radicals. Cytotoxic activity was determined using the MTT method on DU-145 (Human Prostate Cancer Cell Line) and Colo 205 (Human Colon Cancer Cell Line) cell lines. The extract exhibited strong cytotoxic activity against the Colo 205 cell line, with a viability percentage of 33.16±2.01 at a concentration of 3.906 µg/mL. Furthermore, the S. cartilaginea extract demonstrated DNA protective activity on pBR322 plasmid DNA against UV and H2O2 exposure.

Keywords

Cytotoxicity, Lichen, pBR322, Squamarina, Usni acid

Supporting Institution

Yozgat Bozok Üniveristesi

Project Number

number 6601a-FBE/20-433

Thanks

This study was financially supported by the Yozgat Bozok University project with project number 6601a-FBE/20-433.

References

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Details

Primary Language

English

Subjects

Pharmacognosy

Journal Section

Research Article

Authors

Banu Ceren Değirmenci
0009-0000-6777-5415
Türkiye

Mustafa Kocakaya
Türkiye

Selen İlgün
0000-0002-8544-0683
Türkiye

Gökçe Şeker Karatoprak
Türkiye

Zekiye Kocakaya ^*
Türkiye

Ahmet Ceylan
Türkiye

Publication Date

September 30, 2024

Submission Date

January 23, 2024

Acceptance Date

August 19, 2024

Published in Issue

Year 2024 Volume: 45 Number: 3

DOI

https://doi.org/10.17776/csj.1424202

IZ

https://izlik.org/JA89SL39RW

APA

Değirmenci, B. C., Kocakaya, M., İlgün, S., Şeker Karatoprak, G., Kocakaya, Z., & Ceylan, A. (2024). Investigation of Biological Activity of Squamarina cartilaginea (With.) P. James Species Distributed in Türkiye. Cumhuriyet Science Journal, 45(3), 478-485. https://doi.org/10.17776/csj.1424202

AMA

1.Değirmenci BC, Kocakaya M, İlgün S, Şeker Karatoprak G, Kocakaya Z, Ceylan A. Investigation of Biological Activity of Squamarina cartilaginea (With.) P. James Species Distributed in Türkiye. CSJ. 2024;45(3):478-485. doi:10.17776/csj.1424202

Chicago

Değirmenci, Banu Ceren, Mustafa Kocakaya, Selen İlgün, Gökçe Şeker Karatoprak, Zekiye Kocakaya, and Ahmet Ceylan. 2024. “Investigation of Biological Activity of Squamarina Cartilaginea (With.) P. James Species Distributed in Türkiye”. Cumhuriyet Science Journal 45 (3): 478-85. https://doi.org/10.17776/csj.1424202.

EndNote

Değirmenci BC, Kocakaya M, İlgün S, Şeker Karatoprak G, Kocakaya Z, Ceylan A (September 1, 2024) Investigation of Biological Activity of Squamarina cartilaginea (With.) P. James Species Distributed in Türkiye. Cumhuriyet Science Journal 45 3 478–485.

IEEE

[1]B. C. Değirmenci, M. Kocakaya, S. İlgün, G. Şeker Karatoprak, Z. Kocakaya, and A. Ceylan, “Investigation of Biological Activity of Squamarina cartilaginea (With.) P. James Species Distributed in Türkiye”, CSJ, vol. 45, no. 3, pp. 478–485, Sept. 2024, doi: 10.17776/csj.1424202.

ISNAD

Değirmenci, Banu Ceren - Kocakaya, Mustafa - İlgün, Selen - Şeker Karatoprak, Gökçe - Kocakaya, Zekiye - Ceylan, Ahmet. “Investigation of Biological Activity of Squamarina Cartilaginea (With.) P. James Species Distributed in Türkiye”. Cumhuriyet Science Journal 45/3 (September 1, 2024): 478-485. https://doi.org/10.17776/csj.1424202.

JAMA

1.Değirmenci BC, Kocakaya M, İlgün S, Şeker Karatoprak G, Kocakaya Z, Ceylan A. Investigation of Biological Activity of Squamarina cartilaginea (With.) P. James Species Distributed in Türkiye. CSJ. 2024;45:478–485.

MLA

Değirmenci, Banu Ceren, et al. “Investigation of Biological Activity of Squamarina Cartilaginea (With.) P. James Species Distributed in Türkiye”. Cumhuriyet Science Journal, vol. 45, no. 3, Sept. 2024, pp. 478-85, doi:10.17776/csj.1424202.

Vancouver

1.Banu Ceren Değirmenci, Mustafa Kocakaya, Selen İlgün, Gökçe Şeker Karatoprak, Zekiye Kocakaya, Ahmet Ceylan. Investigation of Biological Activity of Squamarina cartilaginea (With.) P. James Species Distributed in Türkiye. CSJ. 2024 Sep. 1;45(3):478-85. doi:10.17776/csj.1424202

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Abstract

Project Number

Investigation of Biological Activity of Squamarina cartilaginea (With.) P. James Species Distributed in Türkiye

Abstract

Keywords

Supporting Institution

Project Number

Thanks

References

Details

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Subjects

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Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

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