Synthesis, Anticholinesterase and Antioxidant Activity of Thiosemicarbazone Derivatives

Betül Kaya; Ulviye Acar Çevik; Abdüllatif Karakaya; Tugba Ercetin

doi:10.17776/csj.1438171

EN

Synthesis, Anticholinesterase and Antioxidant Activity of Thiosemicarbazone Derivatives

Abstract

In this research, we report the synthesis and evaluation of novel thiosemicarbazones as anti-Alzheimer’s agents. The structural clarification of the newly synthesized compounds was carried out by 1H NMR, 13C NMR, and MS analyses. According to the in vitro cholinesterase inhibition assay, compounds showed more inhibitory potential against AChE than BuChE. The in vitro antioxidant activity of the synthesized compounds was measured via two different methods. According to ferrous ion-chelating assay compound 2b demonstrated 5.26% activity when compared to BHT (2.57%). DPPH radical scavenging activity assay revealed that compound 2b showed the most potent antioxidant activity with an IC50 value of 43.91 ± 0.021μM. Among the synthesized compounds, compound 2b was found as the most potent antioxidant agent.

Keywords

Thiosemicarbazone, AChE, BuChE, Antioxidant

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Details

Primary Language

English

Subjects

Pharmaceutical Chemistry

Journal Section

Research Article

Authors

Betül Kaya ^*
0000-0002-1713-9485
Türkiye

Ulviye Acar Çevik
0000-0003-1879-1034
Türkiye

Abdüllatif Karakaya
0009-0003-9619-6705
Türkiye

Tugba Ercetin
0000-0001-7774-7266
Kuzey Kıbrıs Türk Cumhuriyeti

Publication Date

September 30, 2024

Submission Date

February 17, 2024

Acceptance Date

July 22, 2024

Published in Issue

Year 2024 Volume: 45 Number: 3

DOI

https://doi.org/10.17776/csj.1438171

IZ

https://izlik.org/JA37GC43AY

APA

Kaya, B., Acar Çevik, U., Karakaya, A., & Ercetin, T. (2024). Synthesis, Anticholinesterase and Antioxidant Activity of Thiosemicarbazone Derivatives. Cumhuriyet Science Journal, 45(3), 519-523. https://doi.org/10.17776/csj.1438171

AMA

1.Kaya B, Acar Çevik U, Karakaya A, Ercetin T. Synthesis, Anticholinesterase and Antioxidant Activity of Thiosemicarbazone Derivatives. CSJ. 2024;45(3):519-523. doi:10.17776/csj.1438171

Chicago

Kaya, Betül, Ulviye Acar Çevik, Abdüllatif Karakaya, and Tugba Ercetin. 2024. “Synthesis, Anticholinesterase and Antioxidant Activity of Thiosemicarbazone Derivatives”. Cumhuriyet Science Journal 45 (3): 519-23. https://doi.org/10.17776/csj.1438171.

EndNote

Kaya B, Acar Çevik U, Karakaya A, Ercetin T (September 1, 2024) Synthesis, Anticholinesterase and Antioxidant Activity of Thiosemicarbazone Derivatives. Cumhuriyet Science Journal 45 3 519–523.

IEEE

[1]B. Kaya, U. Acar Çevik, A. Karakaya, and T. Ercetin, “Synthesis, Anticholinesterase and Antioxidant Activity of Thiosemicarbazone Derivatives”, CSJ, vol. 45, no. 3, pp. 519–523, Sept. 2024, doi: 10.17776/csj.1438171.

ISNAD

Kaya, Betül - Acar Çevik, Ulviye - Karakaya, Abdüllatif - Ercetin, Tugba. “Synthesis, Anticholinesterase and Antioxidant Activity of Thiosemicarbazone Derivatives”. Cumhuriyet Science Journal 45/3 (September 1, 2024): 519-523. https://doi.org/10.17776/csj.1438171.

JAMA

1.Kaya B, Acar Çevik U, Karakaya A, Ercetin T. Synthesis, Anticholinesterase and Antioxidant Activity of Thiosemicarbazone Derivatives. CSJ. 2024;45:519–523.

MLA

Kaya, Betül, et al. “Synthesis, Anticholinesterase and Antioxidant Activity of Thiosemicarbazone Derivatives”. Cumhuriyet Science Journal, vol. 45, no. 3, Sept. 2024, pp. 519-23, doi:10.17776/csj.1438171.

Vancouver

1.Betül Kaya, Ulviye Acar Çevik, Abdüllatif Karakaya, Tugba Ercetin. Synthesis, Anticholinesterase and Antioxidant Activity of Thiosemicarbazone Derivatives. CSJ. 2024 Sep. 1;45(3):519-23. doi:10.17776/csj.1438171

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