Investigation of Cytotoxic Activity of Anthriscus nemorosa (M.Bieb.) Spreng. on Lung Cancer Cells
Abstract
Medicinal plants are considered an important source of human health due to their therapeutic potential against various diseases including cancer. Cancer is a life-threatening disease characterized by uncontrolled cell growth and abnormal signaling processes. The incidence of cancer in society is increasing day by day. The search for active biological resources is important for the discovery of new anticancer drugs. Anthriscus nemorosa (M.Bieb.) Spreng. (Apiaceae) is a medicinal plant naturally distributed in Turkiye and traditionally used as food and against various diseases. This study investigated the methanol extracts of aerial parts and roots of A. nemorosa for cytotoxicity on lung cancer (A549) and non-cancerous (L929) cell lines. According to the results, both extracts showed significant dose-dependent cytotoxic effects on lung cancer cells. IC50 value was recorded as 8.29 μg/mL in the aerial parts extract. On the other hand, it was recorded as 3.57 μg/mL in the roots extract. Furthermore, the selectivity indexes were calculated as 5.93 and 3.38 for aerial parts and roots extracts, respectively. In light of the findings, it has been concluded that A. nemorosa deserves further anticancer research
Keywords
Anthriscus nemorosa, Apiaceae, Lung cancer, Antiproliferative activity
References
- [1] Al Qaisi Y., Alfarrayeh I., Alsarayreh A., Khleifat K., Abu-Nwas N., Assessment of antioxidant potential, cytotoxicity, and anticancer activity of methanolic extracts from selected wild medicinal plants, Phytomed. Plus., 4 (2) (2024) 100534.
- [2] Bagci E., Aydin E., Ungureanu E., Hritcu L. Anthriscus nemorosa essential oil inhalation prevents memory impairment, anxiety and depression in scopolamine-treated rats, Biomed. Pharmacother., 84 (2016) 1313-1320.
- [3] Menemen Y., Anthriscus Pers. In: Güner A., Aslan S., Ekim T., Vural M., Babaç M.T., (Eds). Türkiye Bitkileri Listesi (Damarlı Bitkiler). İstanbul: Nezahat Gökyiğit Botanic Garden Publications, (2012) 62-64.
- [4] Altundag E., Ozturk M., Ethnomedicinal studies on the plant resources of East Anatolia, Turkey, Procedia Soc. Behav. Sci., 19 (2011) 756-777.
- [5] Gairola S., Sharma J., Bedi Y.S., A cross-cultural analysis of Jammu, Kashmir and Ladakh (India) medicinal plant use, J. Ethnopharmacol., 155 (2) (2014) 925-986.
- [6] Tarakçi Z., Coskun H., Tunçtürk Y., Some properties of fresh and ripened herby cheese, a traditional variety produced in Turkey, Food Technol. Biotechnol., 42 (1) (2004) 47-50.
- [7] Pavlović M., Petrović S., Milenković M., Couladis M., Tzakou O., Niketić M., Chemical composition and antimicrobial activity of Anthriscus nemorosa root essential oil, Nat. Prod. Commun., 6 (2) (2011).
- [8] Karakaya S., Yılmaz S.V., Koca M., Demirci B., Sytar O., Screening of non-alkaloid acetylcholinesterase inhibitors from extracts and essential oils of Anthriscus nemorosa (M. Bieb.) Spreng. (Apiaceae), S. Afr. J. Bot., 125 (2019) 261-269.
- [9] Baldassarri C., Falappa G., Mazzara E., Acquaticci L., Ossoli E., Perinelli D.R., Antitrypanosomal activity of Anthriscus nemorosa essential oils and combinations of their main constituents, Antibiotics, 10 (11) (2021) 1413.
- [10] Forouhandeh H., Zarchini M., Safarzadeh E., Molavi O., Asgharian P., Tarhriz V., Evaluation of the cytotoxic activity of Anthriscus nemorosa on breast cancer cells, J. Contemp. Med. Sci., 7 (4) (2021) 217-226.