Synthesis, DNA Binding and Molecular Docking Studies of Sulfonamide-Triazole Hybrid Compound

Büşra Albayrak Mısır

doi:10.17776/csj.1823568

Synthesis, DNA Binding and Molecular Docking Studies of Sulfonamide-Triazole Hybrid Compound

Abstract

Sulfonamide compounds with the RSO₂NH₂ structure, by modifying the R group to heterocyclic, aromatic or aliphatic, are found in many drugs with a wide range of chemical, physical, and biological properties, including antiviral, diuretic, antibacterial, anticancer, hypoglycemic, and antifungal properties. Sulfonamide-1,2,3-triazole hybrid represent a class of compounds with significant potential in medicinal chemistry due to their versatile biological activities. In this study, novel sulfonamide–triazole derivative was synthesized via Cu(I)-catalyzed azide–alkyne cycloaddition click reaction. The compound was characterized by spectroscopic techniques. DNA binding studies on fish DNA sperm and molecular docking studies were performed on the synthesized compound. DNA-binding studies, including UV-Vis titration and fluorescence spectroscopy indicated predominant minor groove binding, with 4-methyl-N-((1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)methyl)benzenesulfonamide (2) showing the affinity (K_b = 4.9 × 10⁴ M⁻¹) parameters. Molecular docking of compound (2) demonstrated strong binding interactions with DNA consistent with experimental results. Docking studies for compound 2 indicated good oral bioavailability, low toxicity, and favorable pharmacokinetic properties. These findings highlight compound 2 as a promising drug-like candidate for further biological evaluation.

Keywords

DNA binding, Molecular docking, Sulfa drug, 1, 2, 3-Triazole hybrids

Supporting Institution

This study did not receive any support.

Ethical Statement

There is no application in this study that would require an ethics committee decision.

Thanks

This study does not contain any section requiring acknowledgements.

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Details

Primary Language

English

Subjects

Pharmaceutical Biochemistry

Journal Section

Research Article

Authors

Büşra Albayrak Mısır ^*
0009-0002-7061-4668
Türkiye

Publication Date

June 29, 2026

Submission Date

November 14, 2025

Acceptance Date

June 3, 2026

Published in Issue

Year 2026 Volume: 47 Number: 3

DOI

https://doi.org/10.17776/csj.1823568

IZ

https://izlik.org/JA66MT56AR

APA

Albayrak Mısır, B. (2026). Synthesis, DNA Binding and Molecular Docking Studies of Sulfonamide-Triazole Hybrid Compound. Cumhuriyet Science Journal, 47(3), 504-513. https://doi.org/10.17776/csj.1823568

AMA

1.Albayrak Mısır B. Synthesis, DNA Binding and Molecular Docking Studies of Sulfonamide-Triazole Hybrid Compound. CSJ. 2026;47(3):504-513. doi:10.17776/csj.1823568

Chicago

Albayrak Mısır, Büşra. 2026. “Synthesis, DNA Binding and Molecular Docking Studies of Sulfonamide-Triazole Hybrid Compound”. Cumhuriyet Science Journal 47 (3): 504-13. https://doi.org/10.17776/csj.1823568.

EndNote

Albayrak Mısır B (June 1, 2026) Synthesis, DNA Binding and Molecular Docking Studies of Sulfonamide-Triazole Hybrid Compound. Cumhuriyet Science Journal 47 3 504–513.

IEEE

[1]B. Albayrak Mısır, “Synthesis, DNA Binding and Molecular Docking Studies of Sulfonamide-Triazole Hybrid Compound”, CSJ, vol. 47, no. 3, pp. 504–513, June 2026, doi: 10.17776/csj.1823568.

ISNAD

Albayrak Mısır, Büşra. “Synthesis, DNA Binding and Molecular Docking Studies of Sulfonamide-Triazole Hybrid Compound”. Cumhuriyet Science Journal 47/3 (June 1, 2026): 504-513. https://doi.org/10.17776/csj.1823568.

JAMA

1.Albayrak Mısır B. Synthesis, DNA Binding and Molecular Docking Studies of Sulfonamide-Triazole Hybrid Compound. CSJ. 2026;47:504–513.

MLA

Albayrak Mısır, Büşra. “Synthesis, DNA Binding and Molecular Docking Studies of Sulfonamide-Triazole Hybrid Compound”. Cumhuriyet Science Journal, vol. 47, no. 3, June 2026, pp. 504-13, doi:10.17776/csj.1823568.

Vancouver

1.Büşra Albayrak Mısır. Synthesis, DNA Binding and Molecular Docking Studies of Sulfonamide-Triazole Hybrid Compound. CSJ. 2026 Jun. 1;47(3):504-13. doi:10.17776/csj.1823568

As of 2026, Cumhuriyet Science Journal will be published in six issues per year, released in February, April, June, August, October, and December

Synthesis, DNA Binding and Molecular Docking Studies of Sulfonamide-Triazole Hybrid Compound

Abstract

Keywords

Supporting Institution

Ethical Statement

Thanks

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite