Serum Spexin, Kisspeptin-1, Substance P, and Neurokinin-1 Receptor Levels in Hyperemesis Gravidarum: A Prospective Paired Follow-Up Study

Ayça Taş; Dilay Karademir; Tugba Agbektas; Zuhal Tunçbilek; Gülcihan Cinar Kaya; Yavuz Siliğ

doi:10.17776/csj.1862716

Serum Spexin, Kisspeptin-1, Substance P, and Neurokinin-1 Receptor Levels in Hyperemesis Gravidarum: A Prospective Paired Follow-Up Study

Abstract

Hyperemesis gravidarum (HG) is characterized by severe nausea and vomiting during pregnancy and may adversely affect both maternal health and fetal development. This study aimed to investigate serum spexin, kisspeptin-1, substance P, and neurokinin-1 receptor levels, which were hypothesized to be associated with HG. The study was conducted among pregnant women who applied to the Gynecology and Obstetrics Outpatient Clinic of Sivas Cumhuriyet University Faculty of Medicine. A total of 41 pregnant women diagnosed with HG were included. Serum samples were collected from the same participants during the acute HG period and again during the symptom-resolved follow-up period at 20–30 weeks of gestation. Venous blood samples of 4 mL were obtained, and serum spexin, kisspeptin-1, substance P, and neurokinin-1 receptor levels were measured using the ELISA method. No significant differences were observed in serum spexin, kisspeptin-1, substance P, or neurokinin-1 receptor levels between the acute HG period and the symptom-resolved follow-up period (p>0.05). However, significant correlations were detected among these proteins. These findings suggest that serum spexin, kisspeptin-1, substance P, and neurokinin-1 receptor levels were not significantly associated with HG in the present study. Further prospective studies, particularly those including gestational-age-matched healthy pregnant controls, are needed to better clarify the possible roles of these proteins in HG and other pregnancy-related complications.

Keywords

Hyperemesis gravidarum, Kisspeptin-1, Neurokinin-1 Receptor, Spexin, Substance P.

Supporting Institution

N/A

Project Number

N/A

Ethical Statement

Following the design of the study hypothesis, each participant provided written informed consent in accordance with the Declaration of Helsinki. Sivas Cumhuriyet University's Scientific Research and Publication Ethics authorized the study (Date: 20.10.2021; number: 2021/10-44).

Thanks

N/A

References

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Details

Primary Language

English

Subjects

Medical Biochemistry - Proteins, Peptides and Proteomics

Journal Section

Research Article

Authors

Ayça Taş ^*
0000-0002-7132-1325
Türkiye

Dilay Karademir
0000-0002-9813-4255
Türkiye

Tugba Agbektas
0000-0003-3433-8870
Türkiye

Zuhal Tunçbilek
0000-0002-6510-0884
Türkiye

Gülcihan Cinar Kaya
0000-0001-7567-4681
Türkiye

Yavuz Siliğ
0000-0002-0562-7457
Türkiye

Publication Date

June 29, 2026

Submission Date

January 13, 2026

Acceptance Date

May 31, 2026

Published in Issue

Year 2026 Volume: 47 Number: 3

DOI

https://doi.org/10.17776/csj.1862716

IZ

https://izlik.org/JA52ZD43GH

APA

Taş, A., Karademir, D., Agbektas, T., Tunçbilek, Z., Cinar Kaya, G., & Siliğ, Y. (2026). Serum Spexin, Kisspeptin-1, Substance P, and Neurokinin-1 Receptor Levels in Hyperemesis Gravidarum: A Prospective Paired Follow-Up Study. Cumhuriyet Science Journal, 47(3), 418-426. https://doi.org/10.17776/csj.1862716

AMA

1.Taş A, Karademir D, Agbektas T, Tunçbilek Z, Cinar Kaya G, Siliğ Y. Serum Spexin, Kisspeptin-1, Substance P, and Neurokinin-1 Receptor Levels in Hyperemesis Gravidarum: A Prospective Paired Follow-Up Study. CSJ. 2026;47(3):418-426. doi:10.17776/csj.1862716

Chicago

Taş, Ayça, Dilay Karademir, Tugba Agbektas, Zuhal Tunçbilek, Gülcihan Cinar Kaya, and Yavuz Siliğ. 2026. “Serum Spexin, Kisspeptin-1, Substance P, and Neurokinin-1 Receptor Levels in Hyperemesis Gravidarum: A Prospective Paired Follow-Up Study”. Cumhuriyet Science Journal 47 (3): 418-26. https://doi.org/10.17776/csj.1862716.

EndNote

Taş A, Karademir D, Agbektas T, Tunçbilek Z, Cinar Kaya G, Siliğ Y (June 1, 2026) Serum Spexin, Kisspeptin-1, Substance P, and Neurokinin-1 Receptor Levels in Hyperemesis Gravidarum: A Prospective Paired Follow-Up Study. Cumhuriyet Science Journal 47 3 418–426.

IEEE

[1]A. Taş, D. Karademir, T. Agbektas, Z. Tunçbilek, G. Cinar Kaya, and Y. Siliğ, “Serum Spexin, Kisspeptin-1, Substance P, and Neurokinin-1 Receptor Levels in Hyperemesis Gravidarum: A Prospective Paired Follow-Up Study”, CSJ, vol. 47, no. 3, pp. 418–426, June 2026, doi: 10.17776/csj.1862716.

ISNAD

Taş, Ayça - Karademir, Dilay - Agbektas, Tugba - Tunçbilek, Zuhal - Cinar Kaya, Gülcihan - Siliğ, Yavuz. “Serum Spexin, Kisspeptin-1, Substance P, and Neurokinin-1 Receptor Levels in Hyperemesis Gravidarum: A Prospective Paired Follow-Up Study”. Cumhuriyet Science Journal 47/3 (June 1, 2026): 418-426. https://doi.org/10.17776/csj.1862716.

JAMA

1.Taş A, Karademir D, Agbektas T, Tunçbilek Z, Cinar Kaya G, Siliğ Y. Serum Spexin, Kisspeptin-1, Substance P, and Neurokinin-1 Receptor Levels in Hyperemesis Gravidarum: A Prospective Paired Follow-Up Study. CSJ. 2026;47:418–426.

MLA

Taş, Ayça, et al. “Serum Spexin, Kisspeptin-1, Substance P, and Neurokinin-1 Receptor Levels in Hyperemesis Gravidarum: A Prospective Paired Follow-Up Study”. Cumhuriyet Science Journal, vol. 47, no. 3, June 2026, pp. 418-26, doi:10.17776/csj.1862716.

Vancouver

1.Ayça Taş, Dilay Karademir, Tugba Agbektas, Zuhal Tunçbilek, Gülcihan Cinar Kaya, Yavuz Siliğ. Serum Spexin, Kisspeptin-1, Substance P, and Neurokinin-1 Receptor Levels in Hyperemesis Gravidarum: A Prospective Paired Follow-Up Study. CSJ. 2026 Jun. 1;47(3):418-26. doi:10.17776/csj.1862716

As of 2026, Cumhuriyet Science Journal will be published in six issues per year, released in February, April, June, August, October, and December

Serum Spexin, Kisspeptin-1, Substance P, and Neurokinin-1 Receptor Levels in Hyperemesis Gravidarum: A Prospective Paired Follow-Up Study

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