Biochemical Effects of Antioxidant and Hormonal Agents in Skin Aging: A Review

Mustafa Murat Öztürk; Sevgi Durna Daştan

doi:10.17776/csj.1905871

Biochemical Effects of Antioxidant and Hormonal Agents in Skin Aging: A Review

Abstract

Aging is a natural biological process that involves cellular senescence, tissue degradation, and organ function declines. Skin aging involves both intrinsic such as genetic predisposition and endocrine changes, and extrinsic factors such as solar radiation, environmental pollution, and stress factors. All these factors lead to skin aging through biochemical mechanisms and alterations in molecular pathways that include oxidative stress, mitochondria dysfunction, chronic inflammation, and hormonal alterations. Due to its historical context, anti-aging is an ever-trending research subject. Recent advances in molecular biology have further clarified the complex interactions between oxidative damage, signaling pathways, and extracellular matrix remodeling during the skin aging process. Here, mechanistic effects of antioxidant and hormone-based substances that can be used against skin aging were reviewed with particular foci were given to oxidative stress modulation, inflammatory regulation, and alterations on both collagen biosynthesis and cellular signaling. In addition, the safety profiles and potential risks associated with the long-term use of these agents are discussed based on current experimental and clinical evidence.

Keywords

Antioxidants, Hormonal agents, Oxidative stress, Skin aging

Ethical Statement

This study is a review article. No experiments were conducted on humans or animals, and no patient data was used. Therefore, ethical committee approval is not required.

References

Papaccio, F., D′Arino, A., Caputo, S., & Bellei, B. (2022). Focus on the Contribution of Oxidative Stress in Skin Aging. Antioxidants, 11(6), 1121. https://doi.org/10.3390/antiox11061121
Dossena, S., & Marino, A. (2024). Oxidative Stress and Antioxidants in Aging. Antioxidants, 13(11), 1288. https://doi.org/10.3390/antiox13111288
Pullar, J. M., Carr, A. C., & Vissers, M. C. (2017). The roles of vitamin C in skin health. Nutrients, 9(8), 866. https://doi.org/10.3390/nu9080866
Rinnerthaler, M., Bischof, J., Streubel, M. K., Trost, A., & Richter, K. (2015). Oxidative stress in aging human skin. Biomolecules, 5(2), 545–589. https://doi.org/10.3390/biom5020545
Stahl, W., & Sies, H. (2012). β-Carotene and other carotenoids in protection from sunlight. The American Journal of Clinical Nutrition, 96(5), 1179S–84S. https://doi.org/10.3945/ajcn.112.034819
Zasada, M., & Budzisz, E. (2019). Retinoids: Active molecules influencing skin structure formation in cosmetic and dermatological treatments. Postepy Dermatologii i Alergologii, 36(4), 392–397. https://doi.org/10.5114/ada.2019.87443
Pham-Huy, L. A., He, H., & Pham-Huy, C. (2008). Free radicals, antioxidants in disease and health. International Journal of Biomedical Science, 4(2), 89–96. https://doi.org/10.59566/IJBS.2008.4089
Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., Bowe, W. P., Graber, E. M., Harper, J. C., Kang, S., Keri, J. E., Leyden, J. J., Reynolds, R. V., Silverberg, N. B., Stein Gold, L. F., Tollefson, M. M., Weiss, J. S., Dolan, N. C., Sagan, A. A., Stern, M., … Bhushan, R. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945–73.e33. https://doi.org/10.1016/j.jaad.2015.12.037
Bissett, D. L., Oblong, J. E., & Berge, C. A. (2005). Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic Surgery, 31(7 Pt 2), 860–865. https://doi.org/10.1111/j.1524-4725.2005.31732
Surjana, D., Halliday, G. M., & Damian, D. L. (2013). Nicotinamide enhances repair of ultraviolet radiation-induced DNA damage in human keratinocytes and ex vivo skin. Carcinogenesis, 34(5), 1144–1149. https://doi.org/10.1093/carcin/bgt017

Tanno, O., Ota, Y., Kitamura, N., Katsube, T., & Inoue, S. (2000). Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier. The British Journal of Dermatology, 143(3), 524–531. https://doi.org/10.1111/j.1365-2133.2000.03705.x
Draelos, Z. D., Matsubara, A., & Smiles, K. (2006). The effect of 2% niacinamide on facial sebum production. Journal of Cosmetic and Laser Therapy, 8(2), 96–101. https://doi.org/10.1080/14764170600717704
Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology, 3(2), 88–93. https://doi.org/10.1111/j.1473-2130.2004.00115.x
Hakozaki, T., Minwalla, L., Zhuang, J., Chhoa, M., Matsubara, A., Miyamoto, K., Greatens, A., Hillebrand, G. G., Bissett, D. L., & Boissy, R. E. (2002). The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer. The British Journal of Dermatology, 147(1), 20–31. https://doi.org/10.1046/j.1365-2133.2002.04834.x
Koca, F., Yılmaz, E., & Çimen, L. (2025). Vitamins A, E, and C: Mechanisms of Antioxidant Action and Physiological Impact. Sağlık Bilimleri Dergisi, 34(3), 536–545. https://doi.org/10.34108/eujhs.1727061
Al-Niaimi, F., & Chiang, N. Y. Z. (2017). Topical Vitamin C and the Skin: Mechanisms of Action and Clinical Applications. The Journal of Clinical and Aesthetic Dermatology, 10(7), 14–17.
Thiele, J. J., Hsieh, S. N., & Ekanayake-Mudiyanselage, S. (2005). Vitamin E: Critical review of its current use in cosmetic and clinical dermatology. Dermatologic Surgery, 31(7 Pt 2), 805–813. https://doi.org/10.1111/j.1524-4725.2005.31724
Shahidi, F., & de Camargo, A. C. (2016). Tocopherols and Tocotrienols in Common and Emerging Dietary Sources: Occurrence, Applications, and Health Benefits. International Journal of Molecular Sciences, 17(10), 1745. https://doi.org/10.3390/ijms17101745
Lin, J. Y., Selim, M. A., Shea, C. R., Grichnik, J. M., Omar, M. M., Monteiro-Riviere, N. A., & Pinnell, S. R. (2003). UV photoprotection by combination topical antioxidants vitamin C and vitamin E. Journal of the American Academy of Dermatology, 48(6), 866–874. https://doi.org/10.1067/mjd.2003.425
Myhrstad, M. C. W., & Wolk, A. (2023). Antioxidants and phytochemicals – a scoping review for Nordic Nutrition recommendations. Food & Nutrition Research, 67, 10324. https://doi.org/10.29219/fnr.v67.10324
Bai, S., Zhang, M., Tang, S., Li, M., Wu, R., Wan, S., Chen, L., Wei, X., & Feng, S. (2024). Effects and Impact of Selenium on Human Health: A Review. Molecules, 30(1), 50. https://doi.org/10.3390/molecules30010050
Yoshimoto, S., Kohara, N., Sato, N., Ando, H., & Ichihashi, M. (2020). Riboflavin Plays a Pivotal Role in the UVA-Induced Cytotoxicity of Fibroblasts as a Key Molecule in the Production of H2O2 by UVA Radiation in Collaboration with Amino Acids and Vitamins. International Journal of Molecular Sciences, 21(2), 554. https://doi.org/10.3390/ijms21020554
Jomova, K., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2024). Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants. Archives of Toxicology, 98(5), 1323–1367. https://doi.org/10.1007/s00204-024-03696-4
Chaudhary, P., Janmeda, P., Docea, A. O., Yeskaliyeva, B., Abdull Razis, A. F., Modu, B., Calina, D., & Sharifi-Rad, J. (2023). Oxidative stress, free radicals and antioxidants: potential crosstalk in the pathophysiology of human diseases. Frontiers in Chemistry, 11, 1158198. https://doi.org/10.3389/fchem.2023.1158198
Meléndez-Martínez, A. J., Stinco, C. M., & Mapelli-Brahm, P. (2019). Skin Carotenoids in Public Health and Nutricosmetics: The Emerging Roles and Applications of the UV Radiation-Absorbing Colourless Carotenoids Phytoene and Phytofluene. Nutrients, 11(5), 1093. https://doi.org/10.3390/nu11051093
Jeffrey, S., Samraj, P. I., & Raj, B. S. (2021). The Role of Alpha-lipoic Acid Supplementation in the Prevention of Diabetes Complications: A Comprehensive Review of Clinical Trials. Current Diabetes Reviews, 17(9), e011821190404. https://doi.org/10.2174/1573399817666210118145550
Cavinato, M., Waltenberger, B., Baraldo, G., Grade, C. V. C., Stuppner, H., & Jansen-Dürr, P. (2017). Plant extracts and natural compounds used against UVB-induced photoaging. Biogerontology, 18(4), 499–516. https://doi.org/10.1007/s10522-017-9715-7
Stanworth, R. D., & Jones, T. H. (2008). Testosterone for the aging male; current evidence and recommended practice. Clinical Interventions in Aging, 3(1), 25–44. https://doi.org/10.2147/CIA.S190
Xu, X., Chen, X., Hu, H., Dailey, A. B., & Taylor, B. D. (2015). Current opinion on the role of testosterone in the development of prostate cancer: a dynamic model. BMC Cancer, 15, 806. https://doi.org/10.1186/s12885-015-1833-5
Lee, C. H., & Lee, S.-H. (2025). Research Progress on Anti-Aging with Natural Products: From Pathway Modulation to AI-Driven Discovery. Biomolecules, 15(10), 1384. https://doi.org/10.3390/biom15101384
Labrie, F., Bélanger, A., Cusan, L., Gomez, J. L., & Candas, B. (2005). Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging. The Journal of Clinical Endocrinology & Metabolism, 82(8), 2396–2402. https://doi.org/10.1210/jcem.82.8.4162
Baulieu, E. E., Thomas, G., Legrain, S., Lahlou, N., Roger, M., Debuire, B., Faucounau, V., Girard, L., Hervy, M. P., Latour, F., Leaud, M. C., Mokrane, A., Pitti-Ferrandi, H., Trivalle, C., de Lacharrière, O., Nouveau, S., Rakoto-Arison, B., Souberbielle, J. C., Raison, J., Le Bouc, Y., … Forette, F. (2000). Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: contribution of the DHEAge Study to a sociobiomedical issue. Proceedings of the National Academy of Sciences of the United States of America, 97(8), 4279–4284. https://doi.org/10.1073/pnas.97.8.4279
Traish, A. M., Kang, H. P., Saad, F., & Guay, A. T. (2011). Dehydroepiandrosterone (DHEA)—a precursor steroid or an active hormone in human physiology. The Journal of Sexual Medicine, 8(11), 2960–2983. https://doi.org/10.1111/j.1743-6109.2011.02523.x
Rutkowski, K., Sowa, P., Rutkowska-Talipska, J., Kuryliszyn-Moskal, A., & Rutkowski, R. (2014). Dehydroepiandrosterone (DHEA): hypes and hopes. Drugs, 74(11), 1195–1207. https://doi.org/10.1007/s40265-014-0259-8
Handelsman, D. J., Hirschberg, A. L., & Bermon, S. (2018). Circulating Testosterone as the Hormonal Basis of Sex Differences in Athletic Performance. Endocrine Reviews, 39(5), 803–829. https://doi.org/10.1210/er.2018-00020
Xia, W., Quan, T., Hammerberg, C., Voorhees, J. J., & Fisher, G. J. (2015). A mouse model of skin aging: fragmentation of dermal collagen fibrils and reduced fibroblast spreading due to expression of human matrix metalloproteinase-1. Journal of Dermatological Science, 78(1), 79–82. https://doi.org/10.1016/j.jdermsci.2015.01.009
Lee, K. J., An, H. Y., Choi, G. S., Shin, H. T., & Shin, J. (2025). Sebum's effect on wound healing and pigmentation in mice. Skin Health and Disease, 5(5), 344–356. https://doi.org/10.1093/skinhd/vzaf037
Arnautu, A. M., Nimigean, V. R., Nacea-Radu, C. A., Tilici, D. M., & Paun, D. L. (2025). Menopausal Hormone Therapy—Risks, Benefits and Emerging Options: A Narrative Review. International Journal of Molecular Sciences, 26(22), 11098. https://doi.org/10.3390/ijms262211098
Branski, L. K., Thanedar, S., Deen, N., ve diğerleri. (2025). İnsan büyüme hormonunun kullanımıyla ilgili yan etkiler: bir inceleme. Discover Medicine, 2, 316. https://doi.org/10.1007/s44337-025-00474-8
Reiter, R. J., Rosales-Corral, S., Tan, D. X., Jou, M. J., Galano, A., & Xu, B. (2017). Melatonin as a mitochondria-targeted antioxidant: one of evolution's best ideas. Cellular and Molecular Life Sciences, 74(21), 3863–3881. https://doi.org/10.1007/s00018-017-2609-7
Kim, T. K., Lin, Z., Tidwell, W. J., Li, W., & Slominski, A. T. (2015). Melatonin and its metabolites accumulate in the human epidermis in vivo and inhibit proliferation and tyrosinase activity in epidermal melanocytes in vitro. Molecular and Cellular Endocrinology, 404, 1–8. https://doi.org/10.1016/j.mce.2014.07.024
Berardesca, E., & Cameli, N. (2021). Vitamin E supplementation in inflammatory skin diseases. Dermatologic Therapy, 34(6), e15160. https://doi.org/10.1111/dth.15160
Rusanova, I., Martínez-Ruiz, L., Florido, J., Rodríguez-Santana, C., Guerra-Librero, A., Acuña-Castroviejo, D., & Escames, G. (2019). Protective effects of melatonin on the skin: Future perspectives. International Journal of Molecular Sciences, 20(19), 4948. https://doi.org/10.3390/ijms20194948
Zussman, J., Ahdout, J., & Kim, J. (2010). Vitamins and photoaging: do scientific data support their use? Journal of the American Academy of Dermatology, 63(3), 507–525. https://doi.org/10.1016/j.jaad.2009.07.037

Details

Primary Language

English

Subjects

Cell Development, Proliferation and Death

Journal Section

Review

Authors

Mustafa Murat Öztürk ^*
0000-0002-2302-0018
Türkiye

Sevgi Durna Daştan
0009-0003-8565-6841
Türkiye

Publication Date

June 29, 2026

Submission Date

March 9, 2026

Acceptance Date

June 6, 2026

Published in Issue

Year 2026 Volume: 47 Number: 3

DOI

https://doi.org/10.17776/csj.1905871

IZ

https://izlik.org/JA29BT68AG

APA

Öztürk, M. M., & Durna Daştan, S. (2026). Biochemical Effects of Antioxidant and Hormonal Agents in Skin Aging: A Review. Cumhuriyet Science Journal, 47(3), 444-453. https://doi.org/10.17776/csj.1905871

AMA

1.Öztürk MM, Durna Daştan S. Biochemical Effects of Antioxidant and Hormonal Agents in Skin Aging: A Review. CSJ. 2026;47(3):444-453. doi:10.17776/csj.1905871

Chicago

Öztürk, Mustafa Murat, and Sevgi Durna Daştan. 2026. “Biochemical Effects of Antioxidant and Hormonal Agents in Skin Aging: A Review”. Cumhuriyet Science Journal 47 (3): 444-53. https://doi.org/10.17776/csj.1905871.

EndNote

Öztürk MM, Durna Daştan S (June 1, 2026) Biochemical Effects of Antioxidant and Hormonal Agents in Skin Aging: A Review. Cumhuriyet Science Journal 47 3 444–453.

IEEE

[1]M. M. Öztürk and S. Durna Daştan, “Biochemical Effects of Antioxidant and Hormonal Agents in Skin Aging: A Review”, CSJ, vol. 47, no. 3, pp. 444–453, June 2026, doi: 10.17776/csj.1905871.

ISNAD

Öztürk, Mustafa Murat - Durna Daştan, Sevgi. “Biochemical Effects of Antioxidant and Hormonal Agents in Skin Aging: A Review”. Cumhuriyet Science Journal 47/3 (June 1, 2026): 444-453. https://doi.org/10.17776/csj.1905871.

JAMA

1.Öztürk MM, Durna Daştan S. Biochemical Effects of Antioxidant and Hormonal Agents in Skin Aging: A Review. CSJ. 2026;47:444–453.

MLA

Öztürk, Mustafa Murat, and Sevgi Durna Daştan. “Biochemical Effects of Antioxidant and Hormonal Agents in Skin Aging: A Review”. Cumhuriyet Science Journal, vol. 47, no. 3, June 2026, pp. 444-53, doi:10.17776/csj.1905871.

Vancouver

1.Mustafa Murat Öztürk, Sevgi Durna Daştan. Biochemical Effects of Antioxidant and Hormonal Agents in Skin Aging: A Review. CSJ. 2026 Jun. 1;47(3):444-53. doi:10.17776/csj.1905871

As of 2026, Cumhuriyet Science Journal will be published in six issues per year, released in February, April, June, August, October, and December

Biochemical Effects of Antioxidant and Hormonal Agents in Skin Aging: A Review

Abstract

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Ethical Statement

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

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