Comparative α-Glucosidase Inhibitory Activity of Salvia officinalis L., Thymus sipyleus Boiss., and Lavandula stoechas L.

Sevgi Altın

doi:10.17776/csj.1919914

Comparative α-Glucosidase Inhibitory Activity of Salvia officinalis L., Thymus sipyleus Boiss., and Lavandula stoechas L.

Abstract

One of the most important strategies in the management of type 2 diabetes is controlling postprandial hyperglycemia, and α-glucosidase inhibitors are commonly used to achieve this. However, the side effects that may arise from the long-term use of synthetic inhibitors have increased interest in naturally derived alternatives. In this study, the α-glucosidase inhibitory activities of ethanol extracts from Thymus sipyleus Boiss., Salvia officinalis L., and Lavandula stoechas L. were evaluated in comparison with acarbose, a reference inhibitor. The results showed that all plant extracts examined exhibited strong inhibitory activity against α-glucosidase. The highest inhibitory activity was found in S. officinalis (IC₅₀: 2.44±0.086 µg/mL); This was followed by T. sipyleus (2.71±0.40 µg/mL) and acarbose (2.85 ± 0.23 µg/mL). L. stoechas also exhibited significant but lower inhibitory activity (5.68 ± 0.05 µg/mL). The higher α-glucosidase inhibitory activity of S. officinalis and T. sipyleus extracts compared with acarbose suggests that these species may represent promising natural sources of α-glucosidase inhibitors. While the α-glucosidase inhibitory activity of S. officinalis has been previously reported, data regarding T. sipyleus and L. stoechas remain limited. This study provides novel comparative data on the α-glucosidase inhibitory activities of these three species and highlights their potential as promising natural sources of α-glucosidase inhibitors for further investigation.

Keywords

α-Glucosidase inhibition, Salvia officinalis, Thymus sipyleus, Lavandula stoechas, Type 2 diabetes mellitus

References

Kustiawan, P. M., Suwarno, K. N., Pratiwi, V. H., Siregar, K. A. A. K., Herlina, N., Ghozali, G., Mardliyanti, E. et al., (2025). Identification of Homotrigona apicalis propolis compounds as α-glucosidase inhibitors with antidiabetic activity in a molecular docking approach. Vegetos, 1-11. https://doi:10.1007/s42535-025-01538-x
Krishnan, M., Babu, S., & Rahmathullah, A. (2026). Dual dietary assault: Unraveling the synergistic impact of high-fat and high-sucrose intake on type 2 diabetes pathogenesis. Molecular Nutrition & Food Research, 70, 1–15. https://doi.org/10.1002/mnfr.70346
Li, X., Geng-Ji, J. J., Quan, Y. Y., Qi, L. M., Sun, Q., Huang, Q., et al. (2022). Role of potential bioactive metabolites from traditional Chinese medicine for type 2 diabetes mellitus: An overview. Frontiers in Pharmacology, 13, 1–27. https://doi.org/10.3389/fphar.2022.1023713
Feng, Y., Ren, Y., Zhang, X., Yang, S., Jiao, Q., Li, Q., et al. (2024). Metabolites of traditional Chinese medicine targeting PI3K/AKT signaling pathway for hypoglycemic effect in type 2 diabetes. Frontiers in Pharmacology, 15, 1–24. https://doi.org/10.3389/fphar.2024.1373711
Nurkolis, F., Delarue, J., Lau, V., Syahputra, R. A., Tsopmo, A., Hardinsyah, H., et al. (2026). Global mapping of flavonoids in fruits and vegetables: Targeting insulin receptors, GLP-1R, and PPARs to mitigate diabetes. Phytotherapy Research, 40, 116–143. https://doi.org/10.1002/ptr.70116
Li, F., Zeng, K., & Ming, J. (2025). Lowering glycemic levels via gastrointestinal tract factors: The roles of dietary fiber, polyphenols, and their combination. Critical Reviews in Food Science and Nutrition, 65, 575–611. https://doi.org/10.1080/10408398.2023.2278169
Kim, K. J., & Kim, J. Y. (2024). Polyphenols in foods: A potential strategy for preventing and managing the postprandial hyperglycemic response. Food Science and Biotechnology, 33, 2699–2713. https://doi.org/10.1007/s10068-024-01607-y
Kumar, S., Narwal, S., Kumar, V., & Prakash, O. (2011). α-glucosidase inhibitors from plants: A natural approach to treat diabetes. Pharmacognosy Reviews, 5, 19–29. https://doi.org/10.4103/0973-7847.79096
Du, C., & Zhao, Z. (2025). Characteristic analysis of adverse reactions to natural and synthetic alpha-glucosidase inhibitors. Journal of Chromatography B, 1267, 124800. https://doi.org/10.1016/j.jchromb.2025.124800
Assefa, S. T., Yang, E. Y., Chae, S. Y., Song, M., Lee, J., Cho, M. C., et al. (2020). Alpha glucosidase inhibitory activities of plants with focus on common vegetables. Plants, 9. https://doi.org/10.3390/plants9010002

Ramos da Silva, L. R., Ferreira, O. O., Cruz, J. N., de Jesus Pereira Franco, C., Oliveira dos Anjos, T., Cascaes, M. M., et al. (2021). Lamiaceae essential oils, phytochemical profile, antioxidant, and biological activities. Evidence-Based Complementary and Alternative Medicine, 2021. https://doi.org/10.1155/2021/6748052
Napoli, E., Siracusa, L., & Ruberto, G. (2020). New tricks for old guys: Developments in Lamiaceae species. Chemistry & Biodiversity, 17. https://doi.org/10.1002/cbdv.201900677
Karageçili, H., & Gülçin, İ. (2025). The Lamiaceae family plants ethnobotanical and pharmacological properties. Records of Natural Products, 19, 466–487. https://doi.org/10.25135/rnp.529.2505.3521
Luca, S. V., Zengin, G., Sinan, K. I., Skalicka-Woźniak, K., & Trifan, A. (2023). Post-distillation by-products of aromatic plants from Lamiaceae family. Antioxidants, 12. https://doi.org/10.3390/antiox12010210
Waheed, M., Hussain, M. B., Saeed, F., Afzaal, M., Ahmed, A., Irfan, R., et al. (2024). Phytochemical profiling and therapeutic potential of thyme. Food Science & Nutrition, 12, 9893–9912. https://doi.org/10.1002/fsn3.4563
Kowalczyk, A., Przychodna, M., Sopata, S., Bodalska, A., & Fecka, I. (2020). Thymol and thyme essential oil—new insights into selected therapeutic applications. Molecules, 25(18), 4125.
Patil, S. M., Ramu, R., Shirahatti, P. S., Shivamallu, C., & Amachawadi, R. G. (2021). A systematic review on ethnopharmacology, phytochemistry and pharmacological aspects of Thymus vulgaris Linn. Heliyon, 7, e07054. https://doi.org/10.1016/j.heliyon.2021.e07054
Llorent-Martínez, E. J., Ruiz-Medina, A., Zengin, G., Ak, G., Jugreet, S., Mahomoodally, M. F., et al. (2022). New biological and chemical evidences of two Lamiaceae species (Thymbra capitata and Thymus sipyleus subsp. rosulans). Molecules, 27. https://doi.org/10.3390/molecules27249029
Güven, L., Erturk, A., Miloğlu, F. D., Alwasel, S., & Gülçin, İ. (2023). Screening of antiglaucoma, antidiabetic, anti-Alzheimer, and antioxidant activities of Astragalus alopecurus. Pharmaceuticals, 16. https://doi.org/10.3390/ph16050659
Baş, H. (2025). Biotechnological potential of Thymus sipyleus extract in the inhibition of some metabolic enzyme activities (pp. 43–50).
Anwar, F., Mahrye, Khan, R., Qadir, R., Saadi, S., Gruczynska-Sekowska, E., et al. (2024). Exploring the biochemical and nutra-pharmaceutical prospects of some Thymus species – A review. Chemistry & Biodiversity, 21, 1–17. https://doi.org/10.1002/cbdv.202400500
Pirbalouti, A. G., Bistghani, Z. E., & Malekpoor, F. (2016). An overview on genus Thymus. Journal of Herbal Medicine, 6, 93–100.
Kaygısız, M., & Sönmez Gürer, E. (2025). Determination of antimicrobial, antioxidant activities and effects on oxidative DNA damage of extracts from three different Salvia species grown in Turkey. Prospective Pharmaceutical Sciences, 23, 1–8. https://doi.org/10.56782/pps.300
Gali-Muhtasib, H., Hilan, C., & Khater, C. (2000). Traditional uses of Salvia libanotica and the effects of its essential oils. Journal of Ethnopharmacology, 71, 513–520. https://doi.org/10.1016/S0378-8741(99)00190-7
Gürdal, B., & Kültür, Ş. (2013). An ethnobotanical study of medicinal plants in Marmaris (Muğla, Turkey). Journal of Ethnopharmacology, 146, 113–126. https://doi.org/10.1016/j.jep.2012.12.012
Zhumaliyeva, G., Zhussupova, A., Zhusupova, G. E., Błońska-Sikora, E., Cerreto, A., & Omirbekova, N. (2023). Natural compounds of Salvia genus and molecular mechanism of their biological activity. Biomedicines, 11. https://doi.org/10.3390/biomedicines11123151
Afzal, T., Proćków, J., & Łyczko, J. (2025). Bioactive chemical composition and pharmacological insights into Salvia species. Frontiers in Molecular Biosciences, 12. https://doi.org/10.3389/fmolb.2025.1678109
Mervić, M., Štefan, M. B., Kindl, M., Blažeković, B., Marijan, M., & Vladimir-Knežević, S. (2022). Comparative antioxidant and anti-α-glucosidase activities of Mediterranean Salvia species. Plants, 11. https://doi.org/10.3390/plants11050625
Kayalar H., Yılma Zengin S., Demir C., Turan Ü. (2023). Determination of minerals in Lavandula stoechas L. subsp. Cariensis (boiss.) rozeira by x-ray fluorescence spectroscopy. Universal Journal of Pharmaceutical Research, 8(5), https://doi.org/10.22270/ujpr.v8i5.1005.
Ndhlala, A. R., Mesut, İ., & Yüksel, A. K. (2024). Phenolic content analysis of two species belonging to the Lamiaceae family.
Zuzarte, M., Gonçalves, M. J., Cavaleiro, C., Cruz, M. T., Benzarti, A., Marongiu, B., et al. (2013). Antifungal and anti-inflammatory potential of essential oils. Industrial Crops and Products, 44, 97–103. https://doi.org/10.1016/j.indcrop.2012.11.002
Héral, B., Stierlin, É., Fernandez, X., & Michel, T. (2021). Phytochemicals from the genus Lavandula: A review. Phytochemistry Reviews, 20, 751–771. https://doi.org/10.1007/s11101-020-09719-z
Şahinler, S. S., Yılmaz, B. S., Sarıkürkçü, C., & Tepe, B. (2022). Importance of Lavandula stoechas in pharmacognosy. International Journal of Secondary Metabolite, 9, 360–376. https://doi.org/10.21448/ijsm.1098975
Costa, P., Gonçalves, S., Valentão, P., Andrade, P. B., & Romano, A. (2013). Phenolic compounds and antioxidant potential of Lavandula viridis. Food and Chemical Toxicology, 57, 69–74. https://doi.org/10.1016/j.fct.2013.03.006
Wells, R., Truong, F., Adal, A. M., Sarker, L. S., & Mahmoud, S. S. (2018). Lavandula essential oils: Applications in medicinal and food industries. Natural Product Communications, 13, 1403–1417. https://doi.org/10.1177/1934578X1801301038
Batiha, G. E., Teibo, J. O., Wasef, L., Shaheen, H. M., & Akomolafe, A. P. (2023). Pharmacological activities of medicinal plants. Naunyn-Schmiedeberg's Archives of Pharmacology.
Tao, Y., Zhang, Y., Cheng, Y., & Wang, Y. (2013). Screening of α-glucosidase inhibitors from mulberry leaves. Biomedical Chromatography, 27, 148–155. https://doi.org/10.1002/bmc.2761
Altın, S., Işık, M., Alp, C., Dikici, E., Köksal, E., Kırboğa, K. K., et al. (2025). Therapeutic potential of Laurus nobilis extract. Frontiers in Chemistry, 13. https://doi.org/10.3389/fchem.2025.1541250
Mocan, A., Babotă, M., Pop, A., Fizeșan, I., Diuzheva, A., & Locatelli, M. (2020). Biological activities of sage species. Antioxidants, 9. https://doi.org/10.3390/antiox9060480
Mahdi, S., Azzi, R., & Lahfa, F. B. (2020). α-amylase and α-glucosidase inhibitory potential of Salvia officinalis. Diabetes & Metabolic Syndrome, 14, 689–694. https://doi.org/10.1016/j.dsx.2020.05.002
Bahadori, M. B., Asghari, B., Dinparast, L., Zengin, G., Sarikurkcu, C., Abbas-Mohammadi, M., et al. (2017). Salvia nemorosa as a source of bioactive agents. LWT, 75, 42–50. https://doi.org/10.1016/j.lwt.2016.08.048
Djermane, N., Brahmi, M., Adli, D. E., Gliozzi, M., Musolino, V., & Khellaf, R. (2025). Chemical composition and antidiabetic activities of Thymus ciliatus. Chemistry & Biodiversity, 22. https://doi.org/10.1002/cbdv.202403318
Dessalegn, E. (2019). In vitro antidiabetic potential of Thymus species. Journal of Health, Medicine and Nursing, 69, 9–16.
Elrherabi, A., Nasr, F. A., Farihi, A., Bouhrim, M., Loukili, E. H., & Driouech, M. (2025). Therapeutic potential of Lavandula stoechas extract in diabetes. Food Science & Nutrition, 13. https://doi.org/10.1002/fsn3.70469
Aydın, T., Sağlamtaş, R., Gümüştaş, M., Genişel, M., Kazaz, C., & Çakır, A. (2023). Lavandula stoechas as a source for ursolic acid. Chemistry & Biodiversity, 20. https://doi.org/10.1002/cbdv.202300414
Ceylan, Y., Usta, K., Usta, A., Maltaş, E., & Yıldız, S. (2015). Antioxidant activity of Lavandula stoechas. Acta Physica Polonica A, 128, 483–487. https://doi.org/10.12693/APhysPolA.128.B-483
Contreras, M. M., Algieri, F., Rodriguez-Nogales, A., Gálvez, J., & Segura-Carretero, A. (2018). Phytochemical profiling of Lavandula extracts. Electrophoresis, 39, 1284–1293. https://doi.org/10.1002/elps.201700393
Amoah, S. K. S., Sandjo, L. P., Kratz, J. M., & Biavatti, M. W. (2016). Rosmarinic acid: Pharmaceutical and clinical aspects. Planta Medica, 82, 388–406. https://doi.org/10.1055/s-0035-1568274
Ghorbani, A. (2017). Mechanisms of antidiabetic effects of flavonoid rutin. Biomedicine & Pharmacotherapy, 96, 305–312. https://doi.org/10.1016/j.biopha.2017.10.001
Nadeem, M., Imran, M., Gondal, T. A., Imran, A., Shahbaz, M., Amir, R. M., et al. (2019). Therapeutic potential of rosmarinic acid. Applied Sciences, 9.
Khojasteh, A., Mirjalili, M. H., Alcalde, M. A., Cusido, R. M., Eibl, R., & Palazon, J. (2020). Production of rosmarinic acid. Antioxidants, 9. https://doi.org/10.3390/antiox9121273
Guan, H., Luo, W., Bao, B., Cao, Y., Cheng, F., Yu, S., et al. (2022). A comprehensive review of rosmarinic acid. Molecules,27. https://doi.org/10.3390/molecules27103292

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Primary Language

English

Subjects

Enzymes

Journal Section

Research Article

Authors

Sevgi Altın ^*
0000-0002-0820-912X
Türkiye

Publication Date

August 31, 2026

Submission Date

March 31, 2026

Acceptance Date

July 1, 2026

Published in Issue

Year 2026 Volume: 47 Number: 4

DOI

https://doi.org/10.17776/csj.1919914

IZ

https://izlik.org/JA77YR63PH

APA

Altın, S. (2026). Comparative α-Glucosidase Inhibitory Activity of Salvia officinalis L., Thymus sipyleus Boiss., and Lavandula stoechas L. Cumhuriyet Science Journal, 47(4), 658-664. https://doi.org/10.17776/csj.1919914

AMA

1.Altın S. Comparative α-Glucosidase Inhibitory Activity of Salvia officinalis L., Thymus sipyleus Boiss., and Lavandula stoechas L. CSJ. 2026;47(4):658-664. doi:10.17776/csj.1919914

Chicago

Altın, Sevgi. 2026. “Comparative α-Glucosidase Inhibitory Activity of Salvia Officinalis L., Thymus Sipyleus Boiss., and Lavandula Stoechas L”. Cumhuriyet Science Journal 47 (4): 658-64. https://doi.org/10.17776/csj.1919914.

EndNote

Altın S (August 1, 2026) Comparative α-Glucosidase Inhibitory Activity of Salvia officinalis L., Thymus sipyleus Boiss., and Lavandula stoechas L. Cumhuriyet Science Journal 47 4 658–664.

IEEE

[1]S. Altın, “Comparative α-Glucosidase Inhibitory Activity of Salvia officinalis L., Thymus sipyleus Boiss., and Lavandula stoechas L”., CSJ, vol. 47, no. 4, pp. 658–664, Aug. 2026, doi: 10.17776/csj.1919914.

ISNAD

Altın, Sevgi. “Comparative α-Glucosidase Inhibitory Activity of Salvia Officinalis L., Thymus Sipyleus Boiss., and Lavandula Stoechas L”. Cumhuriyet Science Journal 47/4 (August 1, 2026): 658-664. https://doi.org/10.17776/csj.1919914.

JAMA

1.Altın S. Comparative α-Glucosidase Inhibitory Activity of Salvia officinalis L., Thymus sipyleus Boiss., and Lavandula stoechas L. CSJ. 2026;47:658–664.

MLA

Altın, Sevgi. “Comparative α-Glucosidase Inhibitory Activity of Salvia Officinalis L., Thymus Sipyleus Boiss., and Lavandula Stoechas L”. Cumhuriyet Science Journal, vol. 47, no. 4, Aug. 2026, pp. 658-64, doi:10.17776/csj.1919914.

Vancouver

1.Sevgi Altın. Comparative α-Glucosidase Inhibitory Activity of Salvia officinalis L., Thymus sipyleus Boiss., and Lavandula stoechas L. CSJ. 2026 Aug. 1;47(4):658-64. doi:10.17776/csj.1919914

As of 2026, Cumhuriyet Science Journal will be published in six issues per year, released in February, April, June, August, October, and December

Comparative α-Glucosidase Inhibitory Activity of Salvia officinalis L., Thymus sipyleus Boiss., and Lavandula stoechas L.

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