Synthesis, Characterization and In Vitro Antioxidant Activities of New Benzimidazole Ruthenium- (II) Complexes
Abstract
In
this study; it was first intended to synthesize 1-substituted benzimidazole
ligands containing a nitrogen-bound bulky or functional group and then
preparing Ru- (II) -N coordinated metal complexes of these ligands. At last
stage of study it has been investigated that the antioxidant activities of
synthesized metal-complexes. Inert atmosphere-vacuum system has been used for the synthesis of all
complexes. Their structure were characterized by spectroscopic techniques. The in
vitro antioxidant activities of metal complexes were investigated based on the
scavenging of hydroxyl, superoxide and 2,2-diphenyl-1-picrylhydrazyl (DPPH)
radicals. In addition, total antioxidant activity of each metal-complex was
also determined. It was determined that total antioxidant activities
of metal-complexes increased by the order of
3, 4 and 2. Because of decreasing IC50 values indicates that
increasing antioxidant activity, DPPH radical scavenging activity of complex 2, which has lower IC50 value,
was greater than complex 4. IC50
values have not seen for complex 3
for DPPH. It was observed that hydroxyl radical scavenging activities of
complexes increased 4, 3 and 2, while superoxide
radical scavenging activities of complexes increased by the order of 3,
2 and 4, respectively. As a result; newly
synthesized Ru (II) -azole complexes have been found to have significant
antioxidant activity against DPPH, hydroxyl and superoxide radicals.
Keywords
Benzimidazole,Ruthenium,DPPH,Hydroxyl Radical,Superoxide Radical
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