Antifungal Activity of Some Benzimidazole-Hydrazones
Abstract
In the present work, 15 4-(1-(prop-2-in-1-yl)-1H-benzoimidazole-2-yl)-N'-(substitutedmethylene)benzohydrazide
derivatives (4a-4o) were re-synthesized to evaluate their antifungal activity. Structure
identification of synthesized compounds was elucidated by 1H-NMR, 13C-NMR,
and HRMS spectroscopic methods.
Inhibitory potential of the re-synthesized compounds was investigated against Candida supp. The compounds 4e
and 4l showed significant anti fungal activity. Consistent with the
activity studies, 4e was found to be potent derivative with its MIC50
value of (1.95 µg/mL) against Candida
glabrata. And 4l was found to
be potent derivative with its MIC50 value of (1.95 µg/mL) against Candida krusei.
Keywords
References
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