Application of Heterocyclic Compounds as Catalysts in Suzuki-Miyaura Cross-Coupling Reaction
Abstract
Four different benzimidazolium salts (1-4) were prepared in three steps at 80 oC and their
structures were elucidated using spectroscopic methods. The compounds (1-4) obtained were tested in in situ medium as catalyst in the
carbon-carbon (C-C) bond formation reactions of two different boronic acid
derivatives with various aryl halides in the presence of palladium acetate
(PdOAc)2 and sodium
tertiarybutoxide (NaOBut) as a base. With this reaction, four
coupling products (5-8) were
synthesized in different yields ranging from 11 to 93%. Compound 2 from the carbene precursors tested in
the Suzuki-Miyaura cross-coupling reaction was found to be a more effective
catalyst candidate than others.
Keywords
Suzuki-Miyaura coupling reaction,Benzimidazolium salt, Catalyst
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