Trombosit Zengin Fibrin ve Rifamisinin Bir Allogreft ile Kombinasyonda Kemik Büyütme Üzerindeki Etkilerinin Tavşan Tibiasında Eşzamanlı İmplant Yerleştirmesiyle Histomorfometrik Olarak Değerlendirilmesi

Yıl 2017, Cilt: 20 Sayı: 1, 45 - 52, 12.05.2017

İlker Özeç Sancar Şimşek Emre Benlidayı Mehmet Kürkçü

https://doi.org/10.7126/cumudj.307301

Öz

Amaç:
Yüksek profilli dental implant yerleştirilmesinde yönlendirilmiş doku
augmentasyonunu geliştirmek için plateletten zengin fibrin (PRF) ve rifamisin
uygulamasının potansiyelinin değerlendirilmesi.

Materyal
ve metod: İki mm’lik koronal kısmı kemik dışında kalan
dental implantlar kubbe şeklinde sert kaplayıcı titanyum membran ile kapatılmış
ve membranın içi demineralize dondurularak kurutulmuş kemik allogrefti (DFDBA)+salin
(7 tavşan), DFDBA+rifamisin (8 tavşan) veya DFDBA+PRF (8 tavşan) ile
doldurulmuştur.

Bulgular:
Kemik implant kontağı (KİK) salin grubunda 58.43±1.92%, rifamisin grubunda
68.34±20.37% ve PRF grubunda 80.70±2.55% olarak tespit edilmiştir. Sırasıyla
yeni kemik oluşum yüzdesi de 36.90±0.94, 45.26±0.60 ve 51.82±0.82 olarak
bulunmuştur.

Sonuç:
Hem PRF hem de rifamisinin yönlendirilmiş doku augmentasyonunu geliştirici
potansiyeli olduğu ve yüksek profilli dental implant uygulamalarında sert
kaplayıcı titanyum membran altında DFDBA + PRF veya DFDBA + rifamisin
kullanılmasının hem KİK değerini hem de yeni kemik oluşum yüzdesini
artırabileceği görülmüştür.

Anahtar Kelimeler

Kemik Takviyesi, Trombosit bakımından zengin fibrin, rifamisin, Yüksek profilli diş implantları

A HISTOMORPHOMETRIC EVALUATION OF THE EFFECTS OF PLATELET-RICH FIBRIN AND RIFAMYCIN IN COMBINATION WITH AN ALLOGRAFT ON BONE AUGMENTATION WITH SIMULTANEOUS IMPLANT PLACEMENT IN RABBIT TIBIA

Öz

Objective: To evaluate the
potential of platelet-rich fibrin (PRF) and rifamycin to enhance guided bone
augmentation with simultaneous high-profile dental implant placement in a
rabbit tibia model.

Materials and Methods: Dental implants
protruding 2 mm were covered with dome-shaped stiff occlusive titanium barriers
filled with demineralized freeze-dried bone allograft (DFDBA)+saline (7
rabbits), DFDBA + rifamycin (8 rabbits), or DFDB +PRF (8 rabbits). After 4
weeks, the animals were sacrificed, and undecalcified histomorphometric
examination with toluidine blue staining was performed.

Results: The
bone-to-implant contact (BIC) was 58.43 ± 1.92% in the saline group, 68.3 ±20.37%
in the rifamycin group, and 80.70±2.55% in the PRF group, and the percentage of
new bone formation was 36.90 ± 0.94%, 45.26±0.60%, and 51.82±0.82%,
respectively. Conclusions: Both PRF and rifamycin have potential to enhance
GBA, and using DFDBA + PRF or DFDBA+rifamycin beneath a stiff occlusive
titanium barrier next to a high-profile implant may enhance both BIC and new
bone formation.

Keywords: Guided bone augmentation, platelet-rich fibrin, rifamycin, allograft,
high-profile dental implants 

Anahtar Kelimeler

Guided bone augmentation, platelet-rich fibrin, rifamycin, allograft, high-profile dental implants

Kaynakça

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