The Relationship Between the Mandibular Bone Quality Assessed by Digital Panoramic Radiography and Serum Biological Parameters in Patients Planning Dental Implant Surgery

Yıl 2020, Cilt: 23 Sayı: 1, 60 - 67, 18.03.2020

Kaan Orhan Mehmet Özemre Mediha Nur Nişancı Yılmaz Cansu Köseoğlu Seçgin Prof. Dr. Şule Bulut

https://doi.org/10.7126/cumudj.678999

Cited By: 1

Öz

Abstract
Objectives: The aim of this study was to evaluate the bone density of the implant site with panoramic radiomorphometric indices [mandibular cortical index (MCI), mental index (MI)] and to investigate the relationship between bone density and vitamin D, HDL, LDL.
Materials and method: Forty patients with mandibular first molar or second molar tooth deficiency who underwent implant surgery planning were included. Blood samples and panoramic MCI and MI were used to evaluate mandibular bone density.
Results: There was a significant weak positive correlation between MI and Vitamin D and LDL (r = 0.329, p = 0.038; r = 0.341, p = 0.031). Vitamin D, LDL and HDL measurements were not statistically different between MCI groups (p=0.100, p=0.119, p=0.840, respectively).
Conclusions: Vitamin D may be important in addition to radiographic and clinical parameters, and patients should be evaluated in this respect. Further studies are needed to include more patients investigating the relationship between vitamin D and bone quality.
Keywords: dental implants, bone remodeling, vitamin D, HDL cholesterol, LDL cholesterol


Özet
Amaç: Bu çalışmanın amacı, panoramik radyomorfometrik indeksler [mandibular kortikal indeks (MKI), mental indeks (MI)] kullanılarak implant bölgelerinde kemik densitesini değerlendirmek ve kemik densitesi ile D vitamini, HDL ve LDL arasındaki ilişkiyi incelemektir.
Gereç ve Yöntemler: Çalışmaya mandibular birinci molar veya ikinci molar diş eksikliği olup implant cerrahisi planlanan 40 hasta dahil edilmiştir. Mandibular kemik densitesini değerlendirmek için kan örnekleri ve panoramik MKI ve MI kullanılmıştır.
Bulgular: MI ile D vitamini ve LDL arasında anlamlı zayıf pozitif korelasyon bulunmuştur (r = 0.329, p = 0.038; r = 0.341, p = 0.031). MKI grupları arasında D vitamini, LDL ve HDL değerleri bakımından istatistiksel olarak fark bulunamamıştır (sırasıyla p = 0.100, p = 0.119, p = 0.840).
Sonuçlar: D vitamini klinik ve radyolojik parametrelere ek olarak önemli bir faktör olabilmektedir ve hastalar bu açıdan değerlendirilmelidir. D vitamini ile kemik kalitesi arasındaki ilişkiyi araştıran daha çok sayıda hastanın dahil edildiği çalışmalara ihtiyaç vardır.
Anahtar Kelimeler: diş implantları, kemiğin yeniden şekillendirilmesi, vitamin D, HDL kolesterol, LDL kolesterol

Anahtar Kelimeler

dental implants, bone remodeling, vitamin D, HDL cholesterol, LDL cholesterol

Kaynakça

• 1. Kohn DH. Overview of factors important in implant design. J Oral Implant 1992;18 (3):204–219. 2. Jemt T, Lekholm U. Oral implant treatment in edentulous maxillae: A 5-year follow up report on patients with different degrees of jaw resorption. Int J Oral Maxillofac Implants 1995;(10):303–311. 3. Zlataric DK, Celebic A.Clinical bone densitometric evaluation of the mandible in removable denture wearers dependent on the morphology of the mandibular cortex. J Prosthet Dent 2003; 90 (1): 86–91. 4- Taguchi A, Tsuda M, Ohtsuka M. et.al. Use of dental panoramic radiographs in identifying younger postmenopausal women with osteoporosis. Osteoporos Int 2006; 17: 387–394. 5- Devlin H, Karayianni K, Mitsea A. et al. Diagnosing osteoporosis by using dental panoramic radiographs: the OSTEODENT project. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007; 104 (6): 821–828. 6- Klemetti E, Kolmakow S, Kroger H. Pantomography in assessment of the osteoporosis risk group. Scand J Dent Res 1994; 102 (1): 68–72. 7- Silverstein LH, Melkonian RW, Kurtzman D, et.al. Linear tomography in conjunction with pantomography in the assessment of dental implant recipient sites. J Oral Implant 1994;(20): 111–117. 8-Yi X, Yixin Z, Yanjun G. et.al.1α,25-Dihydroxyvitamin D3 increases implant osseointegration in diabetic mice partly through FoxO1 inactivation in osteoblasts. Biochem Biophys Res Commun 2017; 494 (3-4) .626-633. 9- Insua A, Monje A, Wang HL, et.al. Basis of bone metabolism around dental implants during osseointegration and peri-implant bone loss. J Biomed Mater Res Part A 2017: (105 A).2075-2089. 10- Anand N, Chandrasekaran S, Rajput N. Vitamin D and periodontal health: Current concepts. J İndian Soc. Periodontol 2013;17 (3):302-308. 11-Vieth R. Vitamin D toxicity, policy, and science.J Bone Miner Res 2007;22 (suppl 2):64-68. 12-Kogawa M, Findlay DM, Anderson PH, et al.Osteoclastic metabolosim of 25 (OH)-vitamin D3: A potential mechanism for optimization of bone resorption. Endocrinology 2010;151:4613-4625. 13-Leizaola-Cardesa IO, Aguilar-Salvatierra A, Gonzalez-Jaranay M, et al. Bisphosphonates, vitamin D, parathyroid hormone, and osteonecrosis of the jaw. Could there be a missing link? Med Oral Patol Oral Cir Bucal 2016:1;21(2):e236-240 14-Christakos S, Lieben L, Masuyama R, et al. Vitamin D endocrine system and the intestine. Bonekey Rep 2014 ;5(3):496-500. 15-Zhou C, Li Y, Wang X, et al. 1,25Dihydroxy vitamin D(3) improves titanium implant osseointegration in osteoporotic rats. Oral Surg Oral Med Oral Pathol Oral Radiol 2012;114(5 Suppl):174-178. 16-Kelly J, Lin A, Wang CJ, Park S, Nishimura I. Vitamin D and bone-physiology: Demonstration of vitamin D deficiency in an implant osseointegration rat model J Prosthodont. 2009;18(6):473-478. 17-Salomó-Coll O, de Maté-Sánchez JE, Ramírez-Fernandez MP, et al. Osseoinductive elements around immediate implants for better osteointegration: a pilot study in foxhound dogs. Clin Oral Implants Res 2018;29(11):1061-1069. 18-Mangano F, Mortellaro C, Mangano N, Mangano C. Is Low Serum Vitamin D Associated with Early Dental Implant Failure? A Retrospective Evaluation on 1625 Implants Placed in 822 Patients. Mediators Inflamm 2016;2016:5-20. 19-Kennel KA, Drake MT, Hurley DL. Vitamin D deficiency in adults: when to test and how to treat. Mayo Clin Proc 2010;85(8):752-757. 20- Spiro A, Buttriss JL. Vitamin D: An overview of vitamin D status and intake in Europe. Nutr Bull 2014;39 (4):322-530. 21-During A, Penel G, Hardouin P. Understanding the local actions of lipids in bone physiology. Prog Lipid Res 2015;5.126-146. 22-Soares EA, Nakagaki WR, Garcia JA, et al. Effect of hyperlipidemia on femoral biomechanics and morphology in low-density lipoprotein receptor gene knockout mice. J Bone Miner Metab 2012 .;30(4):419-425. 23- Keuroghlian A, Barroso AD, Kirikian G, et al. The effects of hyperlipidemia on implant osseointegration in the mouse femur. J Oral Implantol 2015;41(2):7-11 24- Dündar S, Yaman F, Ozupek MF, Saybak A, Gul M, Asutay F, Kirtay M, Ozercan IH. The effects of high-fat diet on implant osseointegration: an experimental study. J Korean Assoc Oral Maxillofac Surg 2016;42(4):187-192. 25- Dutra V, Yang J, Devlin H, et al. Radiomorphometric indices and their relation to gender, age, and dental status. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005;99: (4) 479–484. 26. Dawson-Hughes B, Harris SS, Dallal GE. Plasma calcidiol, season, and serum parathyroid hormone concentrations in healthy elderly men and women. Am J Clin Nutr 1997;65 (1):67- 71. 27. Chapuy MC, Preziosi P, Maamer M, et al. Prevalence of vitamin D insufficiency in an adult normal population. Osteoporosis Int 1997;7 (5):439-443.