THE EFFECTS OF THE SIDERITIS OZTURKII EXTRACT ON THE EXPRESSION LEVELS OF SOME APOPTOTIC GENES

Abstract

Sideritis öztürkii (Lamiaceae) Aytac & Aksoy is an endemic species to Turkey and used as herbal tea and folk medicine in Central Anatolia.  The purpose of this study is to reveal the apoptotic effects of different extracts derived from S. öztürkii on DLD-1 colorectal cancer cell line via Real Time PCR technique. By this aim, the expression levels of apoptotic genes for each extract were determined via Real Time PCR and then the expression levels were evaluated and compared respectively. Especially, leaf methanol extract was found to be more effective than leaf aqueous extract in terms of apoptosis induction. The results infer that the ironwort extracts have different effects on pro and anti-apoptotic gene expression levels. In conclusion, the leaf and flower extracts have apoptosis inducing activity in the different levels on DLD-1 cell line. 

Keywords

• DLD-1,endemic,Turkey

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