Ethnopharmacological Survey on Phlomis grandiflora: in vivo Antihemorrhoidal Model

Year 2019, , 40 - 46, 29.07.2019

Ceylan Dönmez , Ufuk Koca Çalışkan

https://doi.org/10.38093/cupmap.596972

Cited By: 1

Abstract

Phlomis grandiflora H.S Thompson
var. grandiflora, belongs to
Lamiaceae family, has been utilized traditionally for the treatment of wound,
inflammation, ulcer, diabetes and hemorrhoid mostly. Though hemorrhoids are so
widespread in the world, studies on the prevention and treatment with natural
pharmaceutical preparations of them are quite limited. People, who suffer from
hemorrhoids, tries variety of self treatment methods such as utilizing animal
products and homemade herbal preparations. Aim of this study is to evaluate the
ethnopharmacological application of P.
grandiflora on antihemorrhoidal activity of the leaf methanolic extract,
which was applied topically (50 % cream) for 7 days onto rats having croton
oil-induced hemorrhoid. Changes in the biochemical parameters such as TNF-α and VEGF showed that the plant extract
is slightly more effective at healing hemorrhoids compared to the reference preparation.
This is the first report revealing that the methanolic leaf extract of P. grandiflora showed topical antihemorrhoidal
activity. When chemical studies are taken into consideration, it has been
concluded that the plant extract containing a significant level of phenolic
compounds, might be a promising source for the investigation of the antihemorrhoidal
effect of medicinal plants, in the means of P.
grandiflora, and related disturbances.

Keywords

Ethnopharmacology, hemorrhoid, Phlomis, medicinal food, traditional medicine

Supporting Institution

Gazi University Scientific Research Projects Unit

Project Number

02/2016-03

Thanks

We would like to thank Gazi University Scientific Research Projects Unit for its project (02/2016-03 code number) fund support. We would like to thank Vet. Salih Salar from Kobay Experimental Animals Laboratory.

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