This research study was designed to investigate
physicochemical properties of types of phytosome containing alcohol-free
umckalin from Pelargonium sidoides.
Fourteen different phytosomal formulations were prepared by film method
using P. sidoides in various types of phosphatidylcholine; Phospholipon
85 G (P 85 G) and phospholipon 100H (PL 100H).
Physicochemical properties were measured by particle size and size
distribution, zeta potential and polydispersity index of optimum 4-phytosomal
formulation. Polarized light microscopy (PLM) techniques were employed for
obtaining size distribution and surface appearance and lamellarity. The determination of vesicle types of
phytosomes was performed by using PLM. The most suitable alcohol-free
phytosome combination was chosen as PL 100H: DCP: CHOL (10: 1: 4) containing 1
% P.S (UP 4) because of its particle size and distribution (<1000 nm) and
zeta potential (<-30 mV).
Liposome Phytosome Umckalin Pelargonium sidoides Characterization Alcohol- free extract
The authors would like to special thanks to MSc. Cosm. Bekir Çakıcı and MSc Biologist Leyla Tarhan (SFA R&D Laboratories, İstanbul, Turkey) for their valuable contribution to our research article.
Birincil Dil | İngilizce |
---|---|
Konular | Eczacılık ve İlaç Bilimleri |
Bölüm | Research Articles |
Yazarlar | |
Yayımlanma Tarihi | 27 Haziran 2020 |
Yayımlandığı Sayı | Yıl 2020 |
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