Yıl 2019, Cilt 2 , Sayı 1, Sayfalar 11 - 22 2019-07-29

BIOAPYGIN HERBAL OINTMENT AND PESSARIES COMPARED TO ACIDOSALUS PESSARIES AND VAGINAL PROBIOTIC IN THE TREATMENT OF VULVO-VAGINAL DISORDERS

Višnja Oreščanin [1] , Štefica Findri Guštek [2]



Objective / Purpose: The objective of the study was assessment of the clinical efficacy and safety of BioapigynÒ vaginal ointment and pessaries compared to AcidosalusÒ pessaries and vaginal probiotic in alleviating vulvo-vaginal disorders.


Materials and methods: 124 females were randomly selected into four groups (each of 31 participants) and treated once a day for ten days with: A) BioapigynÒ vaginal pessaries (one pessary per day); B) 2.5 mL of BioapyginÒ vaginal ointment; C) AcidosalusÒ vaginal pessaries (one pessary per day); D) 2.5 mL of AcidosalusÒ vaginal probiotic. All the patients were subjected to gynecological examination, measurement of vaginal pH, Pap test, native and KOH test, self-assessment and clinical assessment of the symptoms at baseline and following the therapy.


Results: Following the treatment with BioapiginÒ vaginal ointment, BioapigynÒ pessaries, AcidosalusÒ pessaries, AcidosalusÒ vaginal probiotic the total score of vulvo-vaginal disorders decreased for 85.2%, 88.9%, 82.7% and 78%, respectively and vaginal pH decreased between 9.1% and 14.3%. Native test showed normalization of the vaginal flora following the treatment with all four products with no significant difference among the products.

Conclusion/Discussion: Both BioapigynÒ and AcidosalusÒ products were highly efficient in alleviation of vulvo-vaginal disorders. The products created unfavorable conditions for pathogenic growth through the lowering of vaginal pH value, promoting the growth of lactobacilli, creating the environment with low water activity and creating a protective layer on the damaged mucosa that creates a physical barrier to the entrance of the pathogens into the cells and enables the recovery of the vaginal mucosa.

Bioapygin, Acidosalus, vulvo-vaginal disorders, vaginal pH, herbal macerates
  • 1. Abdelmonem, A.M., Rasheed, S.M., Mohamed, A., 2012. Bee-honey and yogurt: a novel mixture for treating patients with vulvovaginal candidiasis during pregnancy. Archives of Gynecology and Obstetrics, 286(1), 109-114.
  • 2. Banaeian, S., Sereshti, M., Rafieian, M., Farahbod, F., Kheiri, S., 2017. Comparison of vaginal ointment of honey and clotrimazole for treatment of vulvovaginal candidiasis: A random clinical trial. Journal of Medical Mycology, 27(4), 494-500.
  • 3. Boskey, E.R., Telsch, K.M., Whaley, K.J., Moench, T.R., Cone, R.A., 1999. Acid production by vaginal flora in vitro is consistent with the rate and extent of vaginal acidification. Infection and Immunity, 67, 5170–5175.
  • 4. Caillouette, J.C., Sharp, C.F. Jr, Zimmerman, G.J., Roy, S., 1997. Vaginal pH as a marker for bacterial pathogens and menopausal status. American Journal of Obstetrics and Gynecology, 176, 1270–1275.
  • 5. Calleja-Agius, J., Brincat, M.P., 2015. The urogenital system and the menopause. Climacteric, 18 Suppl 1,18-22.
  • 6. Darvishi, M., Jahdi, F., Hamzegardeshi, Z., Goodarzi, S., Vahedi, M., 2015. The Comparison of Vaginal Cream of Mixing Yogurt, Honey and Clotrimazole on Symptoms of Vaginal Candidiasis. Global Journal of Health Science, 7(6): 108–116.
  • 7. Klebanoff, S.J., Hillier, S.L., Eschenbach, D.A., Waltersdorph, A.M., 1991. Control of the microbial flora of the vagina by H2O2-generating lactobacilli. Journal of Infectious Diseases, 164, 94–100.
  • 8. Larsen B., 1993. Vaginal flora in health and disease. Clinical Obstetrics and Gynecology, 36(1), 107-121.
  • 9. Milsom, I., Arvidsson, L., Ekelund, P., Molander, U., Eriksson, O., 1993. Factors influencing vaginal cytology, pH and bacterial flora in elderly women. Acta Obstetricia et Gynecologica Scandinavica, 72, 286–291.
  • 10. Oreščanin, V., Findri Guštek, Š., 2017. Application of Bioapigyn Herbal Ointment for the Treatment of Lower Genital Tract Infections. Indian Journal of Pharmaceutical Education and Research, 51(3s), 176-179.
  • 11. Panda, S., Das, A., Santa Singh, A., Pala, S., 2014. Vaginal pH: A marker for menopause. Journal of Midlife Health, 5(1), 34–37.
  • 12. Pandit, L., Ouslander, J.G., 1997. Postmenopausal vaginal atrophy and atrophic vaginitis. American Journal of Medical Science, 314, 228–231.
  • 13. Redondo-Lopez, V., Cook, R.L., Sobel, J.D., 1990. Emerging role of lactobacilli in the control and maintenance of the vaginal bacterial microflora. Reviews of infectious diseases, 12, 856–872.
  • 14. Roy, S., Caillouette, J.C., Roy, T., Faden, J.S., 2004. Vaginal pH is similar to follicle-stimulating hormone for menopause diagnosis. American Journal of Obstetrics and Gynecology, 190, 1272–1277.
  • 15. Tuntiviriyapun, P., Panyakhamlerd, K., Triratanachat, S., Chatsuwan, T., Chaikittisilpa, S., Jaisamrarn, U., Taechakraichana, N., 2015. Newly developed vaginal atrophy symptoms II and vaginal pH: a better correlation in vaginal atrophy? Climacteric, 18(2), 246-251.
  • 16. Vahidroodsari, F., Ayati, S., Yousefi, Z., Saeed, S., 2010. Comparing Serum Follicle-Stimulating Hormone (FSH) Level with Vaginal pH in Women with Menopausal Symptoms. Oman Medical Journal, 25(1), 13-26.
Birincil Dil en
Bölüm Articles
Yazarlar

Yazar: Višnja Oreščanin (Sorumlu Yazar)
Kurum: OREŠČANIN Ltd., Laboratory for herbal drugs development
Ülke: Croatia


Yazar: Štefica Findri Guštek

Tarihler

Yayımlanma Tarihi : 29 Temmuz 2019

Bibtex @araştırma makalesi { cupmap552083, journal = {Current Perspectives on Medicinal and Aromatic Plants (CUPMAP)}, issn = {2619-9645}, eissn = {2667-5722}, address = {KİLİS 7 ARALIK ÜNİVERSİTESİ MÜHENDİSLİK-MİMARLIK FAKÜLTESİ GIDA MÜHENDİSLİĞİ BÖLÜMÜ, 79000-KİLİS}, publisher = {Nazım ŞEKEROĞLU}, year = {2019}, volume = {2}, pages = {11 - 22}, doi = {}, title = {BIOAPYGIN HERBAL OINTMENT AND PESSARIES COMPARED TO ACIDOSALUS PESSARIES AND VAGINAL PROBIOTIC IN THE TREATMENT OF VULVO-VAGINAL DISORDERS}, key = {cite}, author = {Oreščanin, Višnja and Findri Guštek, Štefica} }
APA Oreščanin, V , Findri Guštek, Š . (2019). BIOAPYGIN HERBAL OINTMENT AND PESSARIES COMPARED TO ACIDOSALUS PESSARIES AND VAGINAL PROBIOTIC IN THE TREATMENT OF VULVO-VAGINAL DISORDERS. Current Perspectives on Medicinal and Aromatic Plants (CUPMAP) , 2 (1) , 11-22 . Retrieved from https://dergipark.org.tr/tr/pub/cupmap/issue/47875/552083
MLA Oreščanin, V , Findri Guštek, Š . "BIOAPYGIN HERBAL OINTMENT AND PESSARIES COMPARED TO ACIDOSALUS PESSARIES AND VAGINAL PROBIOTIC IN THE TREATMENT OF VULVO-VAGINAL DISORDERS". Current Perspectives on Medicinal and Aromatic Plants (CUPMAP) 2 (2019 ): 11-22 <https://dergipark.org.tr/tr/pub/cupmap/issue/47875/552083>
Chicago Oreščanin, V , Findri Guštek, Š . "BIOAPYGIN HERBAL OINTMENT AND PESSARIES COMPARED TO ACIDOSALUS PESSARIES AND VAGINAL PROBIOTIC IN THE TREATMENT OF VULVO-VAGINAL DISORDERS". Current Perspectives on Medicinal and Aromatic Plants (CUPMAP) 2 (2019 ): 11-22
RIS TY - JOUR T1 - BIOAPYGIN HERBAL OINTMENT AND PESSARIES COMPARED TO ACIDOSALUS PESSARIES AND VAGINAL PROBIOTIC IN THE TREATMENT OF VULVO-VAGINAL DISORDERS AU - Višnja Oreščanin , Štefica Findri Guštek Y1 - 2019 PY - 2019 N1 - DO - T2 - Current Perspectives on Medicinal and Aromatic Plants (CUPMAP) JF - Journal JO - JOR SP - 11 EP - 22 VL - 2 IS - 1 SN - 2619-9645-2667-5722 M3 - UR - Y2 - 2019 ER -
EndNote %0 Current Perspectives on Medicinal and Aromatic Plants (CUPMAP) BIOAPYGIN HERBAL OINTMENT AND PESSARIES COMPARED TO ACIDOSALUS PESSARIES AND VAGINAL PROBIOTIC IN THE TREATMENT OF VULVO-VAGINAL DISORDERS %A Višnja Oreščanin , Štefica Findri Guštek %T BIOAPYGIN HERBAL OINTMENT AND PESSARIES COMPARED TO ACIDOSALUS PESSARIES AND VAGINAL PROBIOTIC IN THE TREATMENT OF VULVO-VAGINAL DISORDERS %D 2019 %J Current Perspectives on Medicinal and Aromatic Plants (CUPMAP) %P 2619-9645-2667-5722 %V 2 %N 1 %R %U
ISNAD Oreščanin, Višnja , Findri Guštek, Štefica . "BIOAPYGIN HERBAL OINTMENT AND PESSARIES COMPARED TO ACIDOSALUS PESSARIES AND VAGINAL PROBIOTIC IN THE TREATMENT OF VULVO-VAGINAL DISORDERS". Current Perspectives on Medicinal and Aromatic Plants (CUPMAP) 2 / 1 (Temmuz 2019): 11-22 .
AMA Oreščanin V , Findri Guštek Š . BIOAPYGIN HERBAL OINTMENT AND PESSARIES COMPARED TO ACIDOSALUS PESSARIES AND VAGINAL PROBIOTIC IN THE TREATMENT OF VULVO-VAGINAL DISORDERS. CUPMAP. 2019; 2(1): 11-22.
Vancouver Oreščanin V , Findri Guštek Š . BIOAPYGIN HERBAL OINTMENT AND PESSARIES COMPARED TO ACIDOSALUS PESSARIES AND VAGINAL PROBIOTIC IN THE TREATMENT OF VULVO-VAGINAL DISORDERS. Current Perspectives on Medicinal and Aromatic Plants (CUPMAP). 2019; 2(1): 22-11.