Yıl 2019, Cilt 2 , Sayı 1, Sayfalar 40 - 46 2019-07-29

Ethnopharmacological Survey on Phlomis grandiflora: in vivo Antihemorrhoidal Model

CEYLAN DÖNMEZ [1] , UFUK KOCA ÇALIŞKAN [2]


Phlomis grandiflora H.S Thompson var. grandiflora, belongs to Lamiaceae family, has been utilized traditionally for the treatment of wound, inflammation, ulcer, diabetes and hemorrhoid mostly. Though hemorrhoids are so widespread in the world, studies on the prevention and treatment with natural pharmaceutical preparations of them are quite limited. People, who suffer from hemorrhoids, tries variety of self treatment methods such as utilizing animal products and homemade herbal preparations. Aim of this study is to evaluate the ethnopharmacological application of P. grandiflora on antihemorrhoidal activity of the leaf methanolic extract, which was applied topically (50 % cream) for 7 days onto rats having croton oil-induced hemorrhoid. Changes in the biochemical parameters such as TNF-α and VEGF showed that the plant extract is slightly more effective at healing hemorrhoids compared to the reference preparation. This is the first report revealing that the methanolic leaf extract of P. grandiflora showed topical antihemorrhoidal activity. When chemical studies are taken into consideration, it has been concluded that the plant extract containing a significant level of phenolic compounds, might be a promising source for the investigation of the antihemorrhoidal effect of medicinal plants, in the means of P. grandiflora, and related disturbances.

Ethnopharmacology, hemorrhoid, Phlomis, medicinal food, traditional medicine
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Yazarlar

Orcid: 0000-0002-8005-4425
Yazar: CEYLAN DÖNMEZ
Kurum: GAZI UNIVERSITY, FACULTY OF PHARMACY
Ülke: Turkey


Orcid: 0000-0002-5216-7588
Yazar: UFUK KOCA ÇALIŞKAN (Sorumlu Yazar)
Kurum: GAZI UNIVERSITY, FACULTY OF PHARMACY
Ülke: Turkey


Destekleyen Kurum Gazi University Scientific Research Projects Unit
Proje Numarası 02/2016-03
Teşekkür We would like to thank Gazi University Scientific Research Projects Unit for its project (02/2016-03 code number) fund support. We would like to thank Vet. Salih Salar from Kobay Experimental Animals Laboratory.
Tarihler

Yayımlanma Tarihi : 29 Temmuz 2019

Bibtex @araştırma makalesi { cupmap596972, journal = {Current Perspectives on Medicinal and Aromatic Plants (CUPMAP)}, issn = {2619-9645}, eissn = {2667-5722}, address = {KİLİS 7 ARALIK ÜNİVERSİTESİ MÜHENDİSLİK-MİMARLIK FAKÜLTESİ GIDA MÜHENDİSLİĞİ BÖLÜMÜ, 79000-KİLİS}, publisher = {Nazım ŞEKEROĞLU}, year = {2019}, volume = {2}, pages = {40 - 46}, doi = {}, title = {Ethnopharmacological Survey on Phlomis grandiflora: in vivo Antihemorrhoidal Model}, key = {cite}, author = {DÖNMEZ, CEYLAN and KOCA ÇALIŞKAN, UFUK} }
APA DÖNMEZ, C , KOCA ÇALIŞKAN, U . (2019). Ethnopharmacological Survey on Phlomis grandiflora: in vivo Antihemorrhoidal Model. Current Perspectives on Medicinal and Aromatic Plants (CUPMAP) , 2 (1) , 40-46 . Retrieved from https://dergipark.org.tr/tr/pub/cupmap/issue/47875/596972
MLA DÖNMEZ, C , KOCA ÇALIŞKAN, U . "Ethnopharmacological Survey on Phlomis grandiflora: in vivo Antihemorrhoidal Model". Current Perspectives on Medicinal and Aromatic Plants (CUPMAP) 2 (2019 ): 40-46 <https://dergipark.org.tr/tr/pub/cupmap/issue/47875/596972>
Chicago DÖNMEZ, C , KOCA ÇALIŞKAN, U . "Ethnopharmacological Survey on Phlomis grandiflora: in vivo Antihemorrhoidal Model". Current Perspectives on Medicinal and Aromatic Plants (CUPMAP) 2 (2019 ): 40-46
RIS TY - JOUR T1 - Ethnopharmacological Survey on Phlomis grandiflora: in vivo Antihemorrhoidal Model AU - CEYLAN DÖNMEZ , UFUK KOCA ÇALIŞKAN Y1 - 2019 PY - 2019 N1 - DO - T2 - Current Perspectives on Medicinal and Aromatic Plants (CUPMAP) JF - Journal JO - JOR SP - 40 EP - 46 VL - 2 IS - 1 SN - 2619-9645-2667-5722 M3 - UR - Y2 - 2019 ER -
EndNote %0 Current Perspectives on Medicinal and Aromatic Plants (CUPMAP) Ethnopharmacological Survey on Phlomis grandiflora: in vivo Antihemorrhoidal Model %A CEYLAN DÖNMEZ , UFUK KOCA ÇALIŞKAN %T Ethnopharmacological Survey on Phlomis grandiflora: in vivo Antihemorrhoidal Model %D 2019 %J Current Perspectives on Medicinal and Aromatic Plants (CUPMAP) %P 2619-9645-2667-5722 %V 2 %N 1 %R %U
ISNAD DÖNMEZ, CEYLAN , KOCA ÇALIŞKAN, UFUK . "Ethnopharmacological Survey on Phlomis grandiflora: in vivo Antihemorrhoidal Model". Current Perspectives on Medicinal and Aromatic Plants (CUPMAP) 2 / 1 (Temmuz 2019): 40-46 .
AMA DÖNMEZ C , KOCA ÇALIŞKAN U . Ethnopharmacological Survey on Phlomis grandiflora: in vivo Antihemorrhoidal Model. CUPMAP. 2019; 2(1): 40-46.
Vancouver DÖNMEZ C , KOCA ÇALIŞKAN U . Ethnopharmacological Survey on Phlomis grandiflora: in vivo Antihemorrhoidal Model. Current Perspectives on Medicinal and Aromatic Plants (CUPMAP). 2019; 2(1): 46-40.