The effect of kanamycin on biochemical parameters following repeated intramuscular administrations in chukar partridges (Alectoris chukar)

Year 2025, Volume: 2 Issue: 1, 7 - 10, 30.06.2025

Orkun Atik , Orhan Çorum , Duygu Durna Çorum , Feray Altan , Baran Erdem , Kamil Üney

Abstract

Kanamycin is an aminoglycoside antibiotic widely used in the treatment of infections caused by aerobic gram-negative bacteria in cattle, horses, pigs, sheep, goats, and poultry. The chukar partridge (Alectoris chukar) plays an important role in the nutrition and hunting industries. The aim of the study was to determine the effect of repeated intramuscular administration of kanamycin at doses of 15 and 100 mg/kg on biochemical parameters in chukar partridge. A total of 18 partridges were randomly divided into three equal groups as control (n=6) and kanamycin groups. A sterile saline solution was administered to the control group. In the other groups, 15 and 100 mg/kg kanamycin were administered intramuscularly, respectively. Kanamycin was administered once daily for 5 days and blood samples were taken at 24, 72, and 120 hours. Serum biochemical parameters were assessed with commercial kits via an auto-analyzer. Kanamycin at a dose of 15 mg/kg increased albumin (ALB) at 120 h and AST (aspartate transaminase) at all sampling times. The administration of kanamycin at a dosage of 100 mg/kg resulted in a notable elevation in ALB, AST, alkaline phosphatase, and cholesterol levels. No difference was observed in other parameters at both dose levels. The results show that kanamycin at the dose of 100 mg/kg can cause liver and lipid metabolism damage in chukar partridges. In the future, further studies on histopathological and molecular techniques are required to delineate the organ damage caused by kanamycin.

Keywords

Alectoris chukar , kanamycin , biochemical parameters

Kanamisinin, çil kekliklerde (Alectoris chukar) tekrarlanan kas içi uygulamalar sonrasında biyokimyasal parametreler üzerindeki etkisi

Abstract

Kanamisin, sığır, at, domuz, koyun, keçi ve kümes hayvanlarında aerobik gram negatif bakterilerin neden olduğu enfeksiyonların tedavisinde yaygın olarak kullanılan bir aminoglikozid antibiyotiktir. Çukar keklik (Alectoris chukar), beslenme ve avcılık endüstrilerinde önemli bir rol oynamaktadır. Çalışmanın amacı, 15 ve 100 mg/kg dozlarında tekrarlanan intramüsküler kanamisin uygulamasının çil kekliklerdeki biyokimyasal parametreler üzerindeki etkisini belirlemektir. Toplam 18 keklik, kontrol grubu (n=6) ve kanamisin grupları olmak üzere üç eşit gruba rastgele bölünmüştür. Kontrol grubuna steril salin solüsyonu uygulandı. Diğer gruplara ise sırasıyla 15 ve 100 mg/kg kanamisin kas içi olarak uygulandı. Kanamisin 5 gün boyunca günde bir kez uygulandı ve 24, 72 ve 120 saatte kan örnekleri alındı. Serum biyokimyasal parametreleri, otomatik analiz cihazı ile ticari kitler kullanılarak değerlendirildi. 15 mg/kg dozunda kanamisin, 120 saatte albümin (ALB) ve tüm örnekleme zamanlarında AST (aspartat transaminaz) düzeylerini artırdı. 100 mg/kg dozunda kanamisin uygulaması, ALB, AST, alkalen fosfataz ve kolesterol düzeylerinde belirgin bir artışa neden oldu. Her iki doz seviyesinde diğer parametrelerde fark gözlenmedi. Sonuçlar, 100 mg/kg dozunda kanamisinin çil kekliklerde karaciğer ve lipit metabolizmasında hasara neden olabileceğini göstermektedir. Gelecekte, kanamisinin neden olduğu organ hasarını tanımlamak için histopatolojik ve moleküler teknikler üzerine daha fazla çalışma yapılması gerekmektedir.

Keywords

Kanamisinin kekliklerdeki güvenliği

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