Use of Topical Tacrolimus in Veterinary Dermatology

Abstract

Tacrolimus (FK506) is a calcineurin inhibitor, macrolide group, immunosuppressive agent, commonly used to prevent tissue rejection after organ transplants. In recent studies, the use of topical tacrolimus has been shown to be effective in the treatment of atopic dermatitis, idiopathic dermatitis of cats, proliferative and necrotizing otitis externa, eosinophilic granuloma complex, lupus erythematosus and pemphigus erythematosus. This review aims to review the pharmacological properties of tacrolimus and its use in veterinary dermatology.

Keywords

• Tacrolimus (FK506),veterinary,dermatology

Topikal Takrolimusun Veteriner Dermatolojide Kullanımı

Abstract

Takrolimus (FK506), organ nakillerinden sonra doku reddini önlemek için yaygın olarak kullanılan, kalsinörin inhibitörü, makrolid grubu, immunsupresif bir ajandır. Son yıllarda yapılan çalışmalarda atopik dermatitis, kedilerin idiyopatik dermatiti, proliferatif nekrotize otitis eksterna, eozinofilik granuloma kompleks, lupus eritematozus, pemfigus eritematozus gibi deri hastalıklarının tedavisinde topikal takrolimus kullanımının etkili olduğu saptanmıştır. Bu derlemede takrolimusun farmakolojik özellikleri ve veteriner dermatolojideki kullanımının gözden geçirilmesi amaçlanmıştır.

Keywords

• Takrolimus (FK506),veteriner,dermatoloji

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