From Diagnosis to Management: Navigating the Complex Terrain of Granulomatous Disease

Hakan Koç; Muhammet İlker Kaya; Nizameddin Koca

doi:10.56016/dahudermj.1459557

EN

From Diagnosis to Management: Navigating the Complex Terrain of Granulomatous Disease

Abstract

In the realm of granulomatous diseases, the convergence of pathophysiology, epidemiology, and therapeutic strategies presents a labyrinth of complexity with far-reaching clinical implications. This review embarks on a scholarly expedition through the intricate landscape of granulomatous inflammation, dissecting the multifaceted presentations ranging from infectious etiologies to enigmatic autoimmune disorders. With a discerning eye on recent advancements and literature, we unravel the nuanced interactions between host defenses and granuloma formation, alongside the pivotal role of cytokines and mononuclear cells in orchestrating these responses. Beyond a mere academic exercise, our exploration delves into the clinical juxtaposition of common and esoteric causes, offering a panoramic view on diagnostic methodologies that straddle the traditional and the innovative. The management of granulomatous diseases, often a tightrope walk balancing efficacy and toxicity, is critically examined, shedding light on conventional and emerging therapies that promise to reshape the therapeutic landscape. By weaving together threads of current research, this review aspires to enhance the understanding of granulomatous diseases and catalyze future inquiries into their mysteries. In doing so, it stands as a beacon for clinicians.

Keywords

Granulomatous Disease, granuloma, cytokines, mononuclear cell, tuberculosis, brucellosis, sarcoidosis, Q fever, Wegener

Ethical Statement

The local ethics committee approval (2011-KAEK-25 2019/07-01) was obtained, and the study was carried out in accordance with the declaration of Helsinki. A written informed consent was obtained from all participants.

Thanks

I would like to thank my estimable teacher Assoc. Prof. Dr. Nizameddin KOCA, who always supported his students in our Internal Medicine training, contributed to our progress and guided us, my colleague Dr. Muhammet İlker KAYA and my wife Lecturer Ayşe BAŞTUĞ KOÇ, who always supported me.

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Details

Primary Language

English

Subjects

Internal Diseases

Journal Section

Systematic Reviews and Meta Analysis

Authors

Hakan Koç ^*
0009-0006-9027-8736
Türkiye

Muhammet İlker Kaya This is me
0000-0002-4078-2444
Türkiye

Nizameddin Koca
0000-0003-1457-4366
Türkiye

Publication Date

April 29, 2024

Submission Date

March 27, 2024

Acceptance Date

April 22, 2024

Published in Issue

Year 2024 Volume: 4 Number: 2

DOI

https://doi.org/10.56016/dahudermj.1459557

IZ

https://izlik.org/JA49LB53TX

APA

Koç, H., Kaya, M. İ., & Koca, N. (2024). From Diagnosis to Management: Navigating the Complex Terrain of Granulomatous Disease. DAHUDER Medical Journal, 4(2), 35-53. https://doi.org/10.56016/dahudermj.1459557

AMA

1.Koç H, Kaya Mİ, Koca N. From Diagnosis to Management: Navigating the Complex Terrain of Granulomatous Disease. DAHUDER MJ. 2024;4(2):35-53. doi:10.56016/dahudermj.1459557

Chicago

Koç, Hakan, Muhammet İlker Kaya, and Nizameddin Koca. 2024. “From Diagnosis to Management: Navigating the Complex Terrain of Granulomatous Disease”. DAHUDER Medical Journal 4 (2): 35-53. https://doi.org/10.56016/dahudermj.1459557.

EndNote

Koç H, Kaya Mİ, Koca N (April 1, 2024) From Diagnosis to Management: Navigating the Complex Terrain of Granulomatous Disease. DAHUDER Medical Journal 4 2 35–53.

IEEE

[1]H. Koç, M. İ. Kaya, and N. Koca, “From Diagnosis to Management: Navigating the Complex Terrain of Granulomatous Disease”, DAHUDER MJ, vol. 4, no. 2, pp. 35–53, Apr. 2024, doi: 10.56016/dahudermj.1459557.

ISNAD

Koç, Hakan - Kaya, Muhammet İlker - Koca, Nizameddin. “From Diagnosis to Management: Navigating the Complex Terrain of Granulomatous Disease”. DAHUDER Medical Journal 4/2 (April 1, 2024): 35-53. https://doi.org/10.56016/dahudermj.1459557.

JAMA

1.Koç H, Kaya Mİ, Koca N. From Diagnosis to Management: Navigating the Complex Terrain of Granulomatous Disease. DAHUDER MJ. 2024;4:35–53.

MLA

Koç, Hakan, et al. “From Diagnosis to Management: Navigating the Complex Terrain of Granulomatous Disease”. DAHUDER Medical Journal, vol. 4, no. 2, Apr. 2024, pp. 35-53, doi:10.56016/dahudermj.1459557.

Vancouver

1.Hakan Koç, Muhammet İlker Kaya, Nizameddin Koca. From Diagnosis to Management: Navigating the Complex Terrain of Granulomatous Disease. DAHUDER MJ. 2024 Apr. 1;4(2):35-53. doi:10.56016/dahudermj.1459557