Recombinant Interferon-Beta1a Use in Six Patients with Myeloproliferative Neoplasms: A First Impression
Abstract
Objective: Assess the safety and efficacy of recombinant interferon-beta1a (rIFN-β1a) in myeloproliferative neoplasm (MPN) patients transitioning from pegylated interferon-alpha2 (peg-IFN-α2).
Method: Retrospective review of six MPN patients switching to rIFN-β1a (44 mcg weekly).
Results: All patients reported myalgia. No other adverse events or treatment discontinuations. Reduced JAK2V617F allele burden in three patients.
Conclusion: rIFN-β1a demonstrated manageable safety in MPN patients, with potential efficacy. Larger studies are needed.
Keywords
Myeloproliferative neoplasms, interferon-beta1a, interferon therapy
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